2016
Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling
Kim B, Chinn AJ, Fandrick DR, Senanayake CH, Singer RA, Miller SJ. Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling. Journal Of The American Chemical Society 2016, 138: 7939-7945. PMID: 27254785, PMCID: PMC5127171, DOI: 10.1021/jacs.6b03444.Peer-Reviewed Original Research
2008
Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation
Lewis JC, Bergman RG, Ellman JA. Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation. Accounts Of Chemical Research 2008, 41: 1013-1025. PMID: 18616300, PMCID: PMC2610463, DOI: 10.1021/ar800042p.Peer-Reviewed Original ResearchConceptsDiverse functional groupsNitrogen heterocyclesCarbene complexesDirect functionalizationBond activationAryl bromidesFunctional groupsH bond functionalization reactionsRh-N-heterocyclic carbene complexesAlkylation of azolesBond functionalization reactionsRh–NHC complexesH bond activationUnique coordination environmentVariety of heterocyclesFunctional group compatibilityNumber of diVariety of substituentsPCy 3Synthetic advancesFragment coordinatesFunctionalization reactionsN-methylbenzimidazoleRobust catalystsDevelopment of ligandsRh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation: Expanded Scope through Mechanistic Insight
Lewis JC, Berman AM, Bergman RG, Ellman JA. Rh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation: Expanded Scope through Mechanistic Insight. Journal Of The American Chemical Society 2008, 130: 2493-2500. PMID: 18251465, PMCID: PMC2693036, DOI: 10.1021/ja0748985.Peer-Reviewed Original ResearchConceptsDirect arylationAryl bromide coupling partnerExcellent product yieldsLow molecular weight ligandsFunctional group tolerant methodPurification of reagentsMolecular weight ligandsTetrafluoroborate saltsBond activationProduct isolationAmide solventsAryl bromidesCoupling partnersWeight ligandsMicrowave reactorArylationCatalyzed ArylationHeterocyclesProduct yieldSolventReactionMechanistic insightsRhAzolesCatalyst
2006
Microwave‐Promoted Rhodium‐Catalyzed Arylation of Heterocycles through CH Bond Activation
Lewis JC, Wu JY, Bergman RG, Ellman JA. Microwave‐Promoted Rhodium‐Catalyzed Arylation of Heterocycles through CH Bond Activation. Angewandte Chemie International Edition 2006, 45: 1589-1591. PMID: 16444794, DOI: 10.1002/anie.200504289.Peer-Reviewed Original Research
2005
One-step synthesis of 2-arylbenzothiazole (‘BTA’) and -benzoxazole precursors for in vivo imaging of β-amyloid plaques
Alagille D, Baldwin R, Tamagnan G. One-step synthesis of 2-arylbenzothiazole (‘BTA’) and -benzoxazole precursors for in vivo imaging of β-amyloid plaques. Tetrahedron Letters 2005, 46: 1349-1351. DOI: 10.1016/j.tetlet.2004.12.111.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply