Rh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation: Expanded Scope through Mechanistic Insight
Lewis JC, Berman AM, Bergman RG, Ellman JA. Rh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation: Expanded Scope through Mechanistic Insight. Journal Of The American Chemical Society 2008, 130: 2493-2500. PMID: 18251465, PMCID: PMC2693036, DOI: 10.1021/ja0748985.Peer-Reviewed Original ResearchConceptsDirect arylationAryl bromide coupling partnerExcellent product yieldsLow molecular weight ligandsFunctional group tolerant methodPurification of reagentsMolecular weight ligandsTetrafluoroborate saltsBond activationProduct isolationAmide solventsAryl bromidesCoupling partnersWeight ligandsMicrowave reactorArylationCatalyzed ArylationHeterocyclesProduct yieldSolventReactionMechanistic insightsRhAzolesCatalyst
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