2024
Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR-T therapies in autoimmunity
Bodansky A, Yu D, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green D, Gauthier J, Turtle C, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung A, Rackaityte E, Wang C, Saxena A, de Dios K, Masi G, Nowak R, O'Connor K, Li H, Diaz V, Saloner R, Casaletto K, Gontrum E, Chan B, Kramer J, Wilson M, Utz P, Hill J, Jackson S, Anderson M, DeRisi J. Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR-T therapies in autoimmunity. Journal Of Clinical Investigation 2024, 134: e180012. PMID: 38753445, PMCID: PMC11213466, DOI: 10.1172/jci180012.Peer-Reviewed Original ResearchB-cell maturation antigenImmunomodulatory therapyPlasma cell-targeted therapyCAR-T therapyCell-targeted therapyAutoantibody mediated diseasesCAR-TAnti-CD19Maturation antigenAutoantibody profileAutoreactive antibodiesTargeted therapyPlasma cellsAutoimmune diseasesAutoantibody repertoireTherapyMediated diseasesAutoantibodiesTherapeutic interventionsProteome-wideDisease statesDiseaseImmunological fingerprintPhIP-SeqMinimal effectClassifying pathogenicity of TPM1 variants of unknown significance using in vitro and in silico approaches
Campbell S, Creso J, Firlar I, Halder S, Lehman W, Rynkiewicz M, Moore J. Classifying pathogenicity of TPM1 variants of unknown significance using in vitro and in silico approaches. Journal Of Cardiac Failure 2024, 30: s3. DOI: 10.1016/j.cardfail.2023.11.005.Peer-Reviewed Original ResearchHypertrophic cardiomyopathyUnknown significanceContractile forceOngoing clinical challengeFirst-degree relativesGenetic testing yieldSlowing of relaxationViral exposureContractile weaknessClinical challengeHypercontractile phenotypeHCM mutationsMyofilament activityHeart tissueMild phenotypeFurther studiesContractile behaviorSignificant increaseHEHTTesting yieldDCM mutationsMinimal effectVUSPathogenicityPhenotype
2023
Targeted social marketing of PrEP and the stigmatization of black sexual minority men
Calabrese S, Kalwicz D, Dovidio J, Rao S, Modrakovic D, Boone C, Magnus M, Kharfen M, Patel V, Zea M. Targeted social marketing of PrEP and the stigmatization of black sexual minority men. PLOS ONE 2023, 18: e0285329. PMID: 37167318, PMCID: PMC10174512, DOI: 10.1371/journal.pone.0285329.Peer-Reviewed Original ResearchConceptsBlack sexual minority menSexual minority menFocus group participantsPrEP stigmaGroup participantsSubject comparisonsMinority menLongitudinal online surveyHIV incidenceGroup comparisonsPrEPMore stigmatizingParticipantsMenFocus groupsMinimal effectStigmaGroupTargeted Social MarketingOnline surveyHIVInteraction effectsSocial marketingSocial marketing initiatives
2018
Effects of Weight-Loss Medications on Cardiometabolic Risk Profiles: A Systematic Review and Network Meta-analysis
Khera R, Pandey A, Chandar AK, Murad MH, Prokop LJ, Neeland IJ, Berry JD, Camilleri M, Singh S. Effects of Weight-Loss Medications on Cardiometabolic Risk Profiles: A Systematic Review and Network Meta-analysis. Gastroenterology 2018, 154: 1309-1319.e7. PMID: 29305933, PMCID: PMC5880739, DOI: 10.1053/j.gastro.2017.12.024.Peer-Reviewed Original ResearchConceptsWeight loss medicationsCardiometabolic risk profileHigh-density lipoprotein cholesterolWaist circumferenceDrug AdministrationSystematic reviewRisk profileLipoprotein cholesterolHemoglobin A1cObese adultsCholesterol profileSystolic/diastolic BPCardiometabolic risk factorsNetwork Meta-AnalysisRandomized clinical trialsQuality of evidenceLow-density lipoproteinModest decreaseOutcomes of interestEffect of foodLong-term useMinimal effectLiraglutide useOrlistat useBlood pressure
2017
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. Current Biology 2017, 27: 1915-1927.e5. PMID: 28669757, PMCID: PMC5698909, DOI: 10.1016/j.cub.2017.05.089.Peer-Reviewed Original ResearchConceptsLocomotor activitySubesophageal zonePeptidergic circuitsPars intercerebralisCorticotropin-releasing factorVentral nerve cordSite of actionReceptor 1Motor outputCircadian locomotor activityNerve cordNeuronsRelevant receptorsDrosophila brainHr rhythmsCircadian driveRhythmFeeding rhythmDiuretic hormone 44Minimal effectActivity rhythmsBehavioral rhythmsCircadian locomotionCircadian controlCord
2016
Covering bariatric surgery has minimal effect on insurance premium costs within the Affordable Care Act
English W, Williams B, Scott J, Morton J. Covering bariatric surgery has minimal effect on insurance premium costs within the Affordable Care Act. Surgery For Obesity And Related Diseases 2016, 12: 1045-1050. PMID: 27260649, DOI: 10.1016/j.soard.2016.03.011.Peer-Reviewed Original ResearchConceptsBariatric surgery coverageBariatric surgerySurgery coverageAffordable Care ActAverage monthly premiumCare ActState health exchangesEssential health benefitsMillions of AmericansSurgeryPublic Use FileMonthly premiumHealth benefitsHealth exchangesUse FileInsurance premium costsBenchmark plansCoverage levelsMinimal effectPremium costs
2014
Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide
Gent JF, Kezik JM, Hill ME, McKay LA, Holford TR, Leaderer BP, Bracken MB. Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide. European Respiratory Journal 2014, 45: 538-540. PMID: 25537555, PMCID: PMC4331059, DOI: 10.1183/09031936.00161514.Peer-Reviewed Original ResearchConceptsAsthma medication useMedication usePregnant womenRisk of wheezePoor pulmonary functionAdverse health outcomesPregnant asthmaticsAsthma exacerbationsAsthma medicationsPerinatal complicationsPulmonary functionFetal growthHealth outcomesPregnancyNO2 exposureWheezeAsthmaMedicationsWomenAmbient nitrogen dioxideMothersMinimal effectExposureAsthmaticsExacerbation
2001
Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation
Heerdt P, Blessios G, Beach M, Hogue C. Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation. Journal Of Cardiothoracic And Vascular Anesthesia 2001, 15: 183-187. PMID: 11312476, DOI: 10.1053/jcan.2001.21947.Peer-Reviewed Original ResearchConceptsAcute tricuspid regurgitationTricuspid regurgitationCardiac outputArteriovenous shuntsSevere regurgitationVenous returnPeripheral arteriovenous shuntsSevere tricuspid regurgitationThermodilution cardiac output measurementsAnesthetized mongrel dogsThermodilution cardiac outputCardiac output measurementsElectromagnetic flowMongrel dogsRegurgitationAnimal studiesThermodilution measurementsShuntThermodilutionVariable degreesMinimal effectMin
1999
Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization
Iwasaki A, Dela Cruz C, Young A, Barber B. Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization. Vaccine 1999, 17: 2081-2088. PMID: 10217610, DOI: 10.1016/s0264-410x(98)00411-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralAntigen PresentationBiolisticsCytokinesEpitopes, T-LymphocyteFemaleGenes, ViralHistocompatibility Antigens Class IInjections, IntramuscularMiceMice, Inbred StrainsNucleocapsid ProteinsNucleoproteinsOrthomyxoviridaeOrthomyxoviridae InfectionsPeptide FragmentsPlasmidsProtein Sorting SignalsRecombinant ProteinsRNA-Binding ProteinsT-Lymphocytes, CytotoxicTumor Cells, CulturedVaccines, DNAViral Core ProteinsConceptsCTL responsesCytotoxic T lymphocyte inductionEpitope-specific CTL responsesT lymphocyte responsesT lymphocyte inductionPlasmid DNA vaccineFull-length antigenLymphocyte responsesIL-12Lymphocyte inductionAntibody responseDNA immunizationDNA vaccineGene gun bombardmentPotent antibodiesGM-CSFCytokine combinationsNeedle injectionInfluenza virusSkeletal muscleSkin epidermisNucleoproteinMinimal effectResponseImmunization
1998
Cyclooxygenase Expression in Bovine Aortic Endothelial Cells Exposed to Cyclic Strain
Kito H, Yokoyama C, Inoue H, Tanabe T, Nakajima N, Sumpio B. Cyclooxygenase Expression in Bovine Aortic Endothelial Cells Exposed to Cyclic Strain. Endothelium 1998, 6: 107-112. PMID: 9930644, DOI: 10.3109/10623329809072197.Peer-Reviewed Original ResearchConceptsAortic endothelial cellsBovine aortic endothelial cellsEndothelial cellsInduction of COXCOX-1 expressionCOX-2 promoter activityExposure of ECsPromoter activityCycles/minCOX-2Cyclooxygenase expressionCOX-1Weak inducerMRNA expressionExtent of inductionNorthern blot analysisBlot analysisTransient transfection experimentsLipopolysaccharideMinimal effectExpressionInductionTransfection experimentsCyclic strainCells
1994
Embryo survival after pronuclear microinjection and trophectoderm biopsy
Burwinkel T, Kim H, Buster J, Minhas B, Carson S. Embryo survival after pronuclear microinjection and trophectoderm biopsy. American Journal Of Obstetrics And Gynecology 1994, 170: 1199-1203. PMID: 8166210, DOI: 10.1016/s0002-9378(94)70122-9.Peer-Reviewed Original ResearchConceptsPronuclear microinjectionBlastocyst stageMurine embryo developmentEmbryonic developmentGene sequencesGene constructsMurine embryosEmbryo developmentEmbryosBlastocyst stateTrophectoderm biopsyPronuclear embryosPseudopregnant femalesEmbryo survivalMicroinjectionCultured controlsRe-expanded embryosPronucleiBlastocystsMinimal effectPronuclearSequenceStageVitroDevelopment
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