Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder
Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, Roberts R, Leckman J, Fernandez T, Abyzov A, Vaccarino F. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder. Biological Psychiatry 2025 PMID: 39892689, DOI: 10.1016/j.biopsych.2024.12.022.Peer-Reviewed Original ResearchActivity of cis-regulatory elementsCis-regulatory elementsMedium spiny neuronsDifferential gene expression analysisChromatin accessibility analysesCell typesDifferential gene expressionGene expression changesMitochondrial oxidative metabolismGene expression analysisSnATAC-seqOpen chromatin datasetsPutative enhancersSynaptic adhesionChromatin datasetsOxidative metabolismEpigenomic regulationTranscriptome analysisActivation of immune responsesIdentified cell typesExpression analysisSynaptic dysfunctionGene expressionExpression changesTranscriptome
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