2010
Goniothalamin Induces Coronary Artery Smooth Muscle Cells Apoptosis: The p53-Dependent Caspase-2 Activation Pathway
Chan K, Rajab N, Siegel D, Bin Din L, Ross D, Inayat-Hussain S. Goniothalamin Induces Coronary Artery Smooth Muscle Cells Apoptosis: The p53-Dependent Caspase-2 Activation Pathway. Toxicological Sciences 2010, 116: 533-548. PMID: 20498002, DOI: 10.1093/toxsci/kfq151.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAmino Acid Chloromethyl KetonesApoptosisCaspase 2Cells, CulturedCytochromes cDose-Response Relationship, DrugEnzyme ActivationHumansHydrogen PeroxideMembrane Potential, MitochondrialMuscle, Smooth, VascularMyocytes, Smooth MuscleNAD(P)H Dehydrogenase (Quinone)Oxygen ConsumptionPyronesSuperoxidesTumor Suppressor Protein p53ConceptsCoronary artery smooth muscle cellsCaspase-2Pan-caspase inhibitor benzyloxycarbonylMitochondrial membrane potential lossAsp-fluoromethyl ketoneRole of mitochondriaExternalization of phosphatidylserineMembrane potential lossCaspase-3 cleavageMitochondrial releaseCaspase-8Molecular mechanismsUpstream signalsArtery smooth muscle cellsDNA damage
2005
Intrinsic Pathway of Hydroquinone Induced Apoptosis Occurs via Both Caspase-Dependent and Caspase-Independent Mechanisms
Inayat-Hussain S, Ross D. Intrinsic Pathway of Hydroquinone Induced Apoptosis Occurs via Both Caspase-Dependent and Caspase-Independent Mechanisms. Chemical Research In Toxicology 2005, 18: 420-427. PMID: 15777082, DOI: 10.1021/tx049762o.Peer-Reviewed Original ResearchConceptsMitochondrial transmembrane potentialLoss of MTPApical caspases-8Caspase-independent mechanismHL-60 cellsJurkat cellsCaspase-8Pan-caspase inhibitor benzyloxycarbonylBenzene metabolite hydroquinonePresence of zVADInvolvement of mitochondriaAsp-fluoromethyl ketoneCaspase-dependent processCytochrome c.Executioner caspase-3Role of mitochondriaCaspase-8 processingPhosphatidyl serine exposureIntrinsic apoptotic pathwayPS exposureJurkat T cellsHL-60Apical caspasesCaspase-9 processingCaspase-Dependent
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