2025
Ni/Ti Dual Catalyzed Cross-Electrophile Coupling between Unactivated Alkyl Chlorides and Aryl Halides
Oniani D, Jia X, Mane E, Charboneau D, Chow J, Hazari N, Huang H, Lee M, Mercado B, Uehling M, Wedal J. Ni/Ti Dual Catalyzed Cross-Electrophile Coupling between Unactivated Alkyl Chlorides and Aryl Halides. ACS Catalysis 2025, 11726-11738. DOI: 10.1021/acscatal.5c01995.Peer-Reviewed Original ResearchCross-electrophile couplingUnactivated alkyl chloridesAlkyl chloridesAryl halidesTi catalystAlkyl radicalsTertiary alkyl chloridesSecondary alkyl chloridesStoichiometric experimentsReactive catalystCatalytic cycleNi catalystsCatalystSubstrate classesHalidesArylRare exampleRate of radical productionMechanistic studiesAlkylationChlorideRadicalsInert substrateIntermediateReaction
2024
Effect of 6,6′-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling
Huang H, Alvarez-Hernandez J, Hazari N, Mercado B, Uehling M. Effect of 6,6′-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling. ACS Catalysis 2024, 14: 6897-6914. PMID: 38737398, PMCID: PMC11087080, DOI: 10.1021/acscatal.4c00827.Peer-Reviewed Original ResearchBulky substituentsNi complexesCross-electrophile couplingNi-catalyzed transformationII oxidation stateActive catalystTurnover frequencyCatalytic performanceAlkyl radicalsCatalytic intermediatesNi catalystsSubstituentsLow-spinCatalytic activityOxidation stateCl speciesHigh-spinCatalystLigandRoom temperatureBu2ReactionComplexPrecatalystXeC
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