Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers
Shen Z, Vargas-Rivera M, Rigby E, Chen S, Ellman J. Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers. ACS Catalysis 2022, 12: 12860-12868. PMID: 36406894, PMCID: PMC9668057, DOI: 10.1021/acscatal.2c03672.Peer-Reviewed Original ResearchHydrogen atom transferReversible hydrogen atom transferDensity functional theory calculationsDeuterium-labelling reactionFunctional theory calculationsFunctional group compatibilityHAT mechanismAtom transferStereoselective epimerizationHAT pathwayNitrogen heterocyclesLuminescence quenchingStable isomerDiastereomer pairsTheory calculationsGroup compatibilityVisible lightStable stereoisomersStereochemical configurationSubstitution patternLabeling reactionRelative energiesMorpholineEpimerizationMechanistic studies
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