2023
Neuroimaging Correlates of Internet Gaming Disorder: Can We Achieve the Promise of Translating Understanding of Brain Functioning Into Clinical Advances?
Mestre-Bach G, Potenza M. Neuroimaging Correlates of Internet Gaming Disorder: Can We Achieve the Promise of Translating Understanding of Brain Functioning Into Clinical Advances? The Canadian Journal Of Addiction 2023, 14: 7-17. PMID: 38371925, PMCID: PMC10871672, DOI: 10.1097/cxa.0000000000000178.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOld Models Know Wrinkles Best
Arellano J, Rakic P. Old Models Know Wrinkles Best. 2023, 499-525. DOI: 10.1002/9781119860914.ch23.Peer-Reviewed Original Research
2022
Systematic identification of biomarker-driven drug combinations to overcome resistance
Rees M, Brenan L, do Carmo M, Duggan P, Bajrami B, Arciprete M, Boghossian A, Vaimberg E, Ferrara S, Lewis T, Rosenberg D, Sangpo T, Roth J, Kaushik V, Piccioni F, Doench J, Root D, Johannessen C. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nature Chemical Biology 2022, 18: 615-624. PMID: 35332332, DOI: 10.1038/s41589-022-00996-7.Peer-Reviewed Original ResearchConceptsSmall molecule responsesCell linesGSK-J4Gene expression featuresMonoacylglycerol lipaseGene knockoutSerine hydrolaseCancer cell linesSystematic identificationCell viability profileInsensitive cell linesNovel relationshipSmall moleculesMechanism of actionEnzymatic modificationSpecific mechanismsViability profileIntrinsic resistanceVariable responseMechanistic studiesRational candidatesMechanism
2020
TCP5 controls leaf margin development by regulating KNOX and BEL-like transcription factors in Arabidopsis
Yu H, Zhang L, Wang W, Tian P, Wang W, Wang K, Gao Z, Liu S, Zhang Y, Irish VF, Huang T. TCP5 controls leaf margin development by regulating KNOX and BEL-like transcription factors in Arabidopsis. Journal Of Experimental Botany 2020, 72: 1809-1821. PMID: 33258902, DOI: 10.1093/jxb/eraa569.Peer-Reviewed Original ResearchConceptsTranscription factorsLeaf marginsLeaf margin developmentTCP transcription factorsSpatial-specific mannerLeaf morphogenesisLeaf serrationGene functionRedundant rolesKNAT3Key regulatorTCP5Saw1MorphogenesisMargin developmentSpecific mechanismsKey mechanismArabidopsisImportant processTranscriptionLeavesRegulatorRegulationMechanismOutgrowthChapter 7 Neuroprotective roles of neurotrophic growth factors in mood disorders
Jiang C, Salton S. Chapter 7 Neuroprotective roles of neurotrophic growth factors in mood disorders. 2020, 145-172. DOI: 10.1016/b978-0-12-814037-6.00010-0.Peer-Reviewed Original ResearchBrain-derived neurotrophic factorNeurotrophic growth factorsMood disordersAntidepressant efficacyDepressive behaviorGrowth factorDepression-like behaviorAntidepressant actionAntidepressant responseDendritic lengthNeuroprotective roleSpine densityNeurotrophic factorNeurotrophin actionNeuronal cytoarchitectureAnimal modelsGene polymorphismsSynaptic plasticityProtein levelsDisordersReceptorsGenetic associationEfficacySpecific mechanismsCritical role
2019
Group- Versus Parent-Involvement CBT for Childhood Anxiety Disorders: Treatment Specificity and Long-Term Recovery Mediation
Silverman WK, Marin CE, Rey Y, Kurtines WM, Jaccard J, Pettit JW. Group- Versus Parent-Involvement CBT for Childhood Anxiety Disorders: Treatment Specificity and Long-Term Recovery Mediation. Clinical Psychological Science 2019, 7: 840-855. PMID: 33758679, PMCID: PMC7984418, DOI: 10.1177/2167702619830404.Peer-Reviewed Original ResearchGroup cognitive behavioral therapyParental psychological controlPsychological controlAnxiety reductionAnxiety disordersYouth anxiety disordersChildhood anxiety disordersPrimary anxiety diagnosisCognitive behavioral therapyTreatment specificityYouth anxietyCBT targetsBehavioral therapyAnxiety diagnosesCBTMediationPutative mediatorsPosttreatmentDisordersAnxietyYouthEfficacy trialsMediatorsParentsSpecific mechanisms
2018
Social determinants of tuberculosis evaluation among household contacts: a secondary analysis
Shelby T, Meyer AJ, Ochom E, Turimumahoro P, Babirye D, Katamba A, Davis JL, Armstrong-Hough M. Social determinants of tuberculosis evaluation among household contacts: a secondary analysis. Public Health Action 2018, 8: 118-123. PMID: 30271727, PMCID: PMC6147061, DOI: 10.5588/pha.18.0025.Peer-Reviewed Original ResearchTB evaluationHousehold contactsContact investigationSocial determinantsHousehold contact investigationCross-sectional studyTuberculosis evaluationTB patientsPrimary level educationTuberculosis unitSputum collectionControl armIndividual symptomsSecondary analysisLow incomeSpecific mechanismsSocio-economic determinantsMedian incomeHead of householdFurther researchSocio-economic factorsPatientsDeterminantsClinicEvaluation
2017
Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice
Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behavioural Brain Research 2017, 334: 72-77. PMID: 28743602, PMCID: PMC5580257, DOI: 10.1016/j.bbr.2017.07.027.Peer-Reviewed Original ResearchConceptsAdult male miceNicotine intakeMale micePsychostimulant effectsPsychostimulant propertiesHome cage locomotor activitySex-dependent mannerSex-dependent mechanismsBlood levelsAdolescent miceFemale miceLocomotor stimulationLocomotor activityNicotine sensitivityAge groupsE-cigarettesMiceIntakeSignificant decreaseNicotineAgeSexBehavioral changesAdultsSpecific mechanisms
2012
The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation
Choy A, Dancourt J, Mugo B, O’Connor T, Isberg RR, Melia TJ, Roy CR. The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation. Science 2012, 338: 1072-1076. PMID: 23112293, PMCID: PMC3682818, DOI: 10.1126/science.1227026.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAutophagyAutophagy-Related Protein 7Autophagy-Related Protein 8 FamilyAutophagy-Related ProteinsBacterial ProteinsCell Culture TechniquesCysteine ProteasesGene DeletionGlycineHEK293 CellsHost-Pathogen InteractionsHumansHydrolysisLegionella pneumophilaLegionnaires' DiseaseMicrofilament ProteinsPhagosomesUbiquitin-Activating EnzymesUbiquitin-Conjugating EnzymesConceptsATG8 proteinsIntracellular pathogen Legionella pneumophilaPathogen Legionella pneumophilaAdjacent aromatic residuesCarboxyl-terminal glycine residueAutophagosome membraneEukaryotic cellsAutophagy pathwayGlycine residueAromatic residuesIntracellular pathogensRavZAutophagyProteinLegionella pneumophilaSpecific mechanismsResiduesPathogensATG3MicrobesAtg7CytosolVacuolesPathwayPneumophila
2009
Natural, Unexpected Deaths: Reliability of a Presumptive Diagnosis*
Gill J, Scordi‐Bello I. Natural, Unexpected Deaths: Reliability of a Presumptive Diagnosis*. Journal Of Forensic Sciences 2009, 55: 77-81. PMID: 20002277, DOI: 10.1111/j.1556-4029.2009.01227.x.Peer-Reviewed Original Research
2007
Mechanisms Regulating Human FMO3 Transcription
Klick D, Hines R. Mechanisms Regulating Human FMO3 Transcription. Drug Metabolism Reviews 2007, 39: 419-442. PMID: 17786630, DOI: 10.1080/03602530701498612.Peer-Reviewed Original ResearchConceptsGC-box binding proteinsHepG2 cellsPromoter characterizationLiver nuclear proteinsNuclear proteinsTransient expressionFMO enzymesDevelopmental expressionBinding proteinTranscriptionAdult regulationProteinSpecific mechanismsEnzymeExpressionCellsNFYMajor roleYY1USF1Oxidative drugsHeterodimersMonooxygenasesReporterIsoforms
2005
Does the Impact of Managed Care on Substance Abuse Treatment Services Vary by Provider Profit Status?
Olmstead TA, Sindelar JL. Does the Impact of Managed Care on Substance Abuse Treatment Services Vary by Provider Profit Status? Health Services Research 2005, 40: 1862-1882. PMID: 16336553, PMCID: PMC1361225, DOI: 10.1111/j.1475-6773.2005.00431.x.Peer-Reviewed Original ResearchConceptsSubstance abuse treatment servicesTreatment servicesSAT facilitiesImpact of MCQuality of careFacility ownership typeFacility ownershipArea Resource FileFP clinicsTherapy/counselingRange of servicesSAT servicesMC activityManaged CareResource FileCareNational surveyTransitional servicesMedical testingSpecific mechanismsProfit statusInvolvementFurther researchSpermatozoal nuclear determinants of reproductive outcome: implications for ART
Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Human Reproduction Update 2005, 11: 337-349. PMID: 15863434, DOI: 10.1093/humupd/dmi011.Peer-Reviewed Original ResearchConceptsPaternal genomeEpigenetic regulationChromosome contentDNA strand breaksNuclear determinantsStrand breaksGenomeImportant functionsNuclear factorRecent findingsSpecific mechanismsReproductive outcomesExact mechanismNumerical abnormalitiesAssisted reproduction technology (ART) outcomesTreatment addressesReproductionMale factor infertilityY chromosome microdeletionsMale fertility potentialRegulationOocytesMechanismChromosome microdeletionsFactor infertility
2003
Parvoviruses
Tattersall P, Cotmore S. Parvoviruses. 2003 DOI: 10.1038/npg.els.0000423.Peer-Reviewed Original Research
2000
Use of Oligonucleotide Arrays to Analyze Drug Toxicity
KAMINSKI N, ALLARD J, HELLER R. Use of Oligonucleotide Arrays to Analyze Drug Toxicity. Annals Of The New York Academy Of Sciences 2000, 919: 1-8. PMID: 11083091, DOI: 10.1111/j.1749-6632.2000.tb06861.x.Peer-Reviewed Original Research
1998
Perforin protects against autoimmunity in lupus-prone mice.
Peng S, Moslehi J, Robert M, Craft J. Perforin protects against autoimmunity in lupus-prone mice. The Journal Of Immunology 1998, 160: 652-60. PMID: 9551899, DOI: 10.4049/jimmunol.160.2.652.Peer-Reviewed Original ResearchConceptsLupus-prone miceAutoantibody productionImmune complex renal diseaseLupus-prone animalsPerforin-mediated cytotoxicityEnd-organ diseaseComplex renal diseaseAccelerated autoimmunityRenal diseaseLpr miceImmune homeostasisSystemic autoimmunityT cellsImmune systemAbnormal accumulationLpr animalsAutoimmunityFas AgMiceHypergammaglobulinemiaPerforinDiseaseAnimalsSpecific mechanismsRegulatory mechanisms
1993
Molecular mechanisms of trauma-induced neuronal degeneration.
Lipton S. Molecular mechanisms of trauma-induced neuronal degeneration. Current Opinion In Neurology 1993, 6: 588-96. PMID: 8400474.Peer-Reviewed Original Research
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