2024
Modifications on histone tails in Parkinson's disease.
Mao Q, Luo Z, Wang K, Chen B, Wang Z, Zhang Y, Wang X, Luo X. Modifications on histone tails in Parkinson's disease. SciBase Neurology 2024, 2 PMID: 39145143, PMCID: PMC11323098, DOI: 10.52768/neurology/1017.Peer-Reviewed Original ResearchHistone modificationsEpigenetic regulation of genesGene regulatory regionsGene expression regulationHistone tail modificationsRegulation of genesHistone marksChromatin structureRepressive marksRegulatory regionsExpression regulationHistone tailsTail modificationsHistone H2AEpigenetic modificationsEpigenetic regulationEpigenetic mechanismsHistoneGene expressionGenesGSK-J4Neural stem cellsA-synucleinEnvironmental factorsParkinson's disease
2022
Systematic identification of biomarker-driven drug combinations to overcome resistance
Rees M, Brenan L, do Carmo M, Duggan P, Bajrami B, Arciprete M, Boghossian A, Vaimberg E, Ferrara S, Lewis T, Rosenberg D, Sangpo T, Roth J, Kaushik V, Piccioni F, Doench J, Root D, Johannessen C. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nature Chemical Biology 2022, 18: 615-624. PMID: 35332332, DOI: 10.1038/s41589-022-00996-7.Peer-Reviewed Original ResearchConceptsSmall molecule responsesCell linesGSK-J4Gene expression featuresMonoacylglycerol lipaseGene knockoutSerine hydrolaseCancer cell linesSystematic identificationCell viability profileInsensitive cell linesNovel relationshipSmall moleculesMechanism of actionEnzymatic modificationSpecific mechanismsViability profileIntrinsic resistanceVariable responseMechanistic studiesRational candidatesMechanism
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