2025
Exploring the complexity of MECP2 function in Rett syndrome
Liu Y, Whitfield T, Bell G, Guo R, Flamier A, Young R, Jaenisch R. Exploring the complexity of MECP2 function in Rett syndrome. Nature Reviews Neuroscience 2025, 26: 379-398. PMID: 40360671, DOI: 10.1038/s41583-025-00926-1.Peer-Reviewed Original ResearchConceptsMethylated DNA binding protein MeCP2Neuronal gene regulationReview recent insightsChromatin structureTranscriptional regulationGene regulationInteraction hubProtein MeCP2Cofactor interactionsTranscription factorsEpigenetic regulationRett syndromeProteomic studiesDiverse processesMolecular mechanismsMeCP2 functionTherapeutic designMeCP2Neuronal functionRegulationModel systemNeurodevelopmental disordersRepressorChromatinMechanistic studiesContemporary management paradigms and emerging therapeutics for myelodysplastic syndromes/neoplasms
Ramanathan R, Xie Y, Badar T, Zeidan A, Patel S. Contemporary management paradigms and emerging therapeutics for myelodysplastic syndromes/neoplasms. British Journal Of Haematology 2025, 206: 1571-1581. PMID: 40302714, DOI: 10.1111/bjh.20116.Peer-Reviewed Original ResearchConceptsInvestigational therapiesTraditional erythropoiesis-stimulating agentsContemporary treatment optionsMulticentre randomized trialSubsets of patientsErythropoiesis-stimulating agentsResponse to therapeuticsFood and Drug AdministrationU.S. Food and Drug AdministrationClinical trial designHypomethylating agentsMutated TP53Treatment landscapeComprehensive genomic sequencingTreatment optionsRandomized trialsDrug AdministrationContemporary management paradigmTherapyTrial dataTrial designLowered riskTherapeutic designTherapeuticsVenetoclax
2016
Metabolite and Microbiome Interplay in Cancer Immunotherapy
Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Metabolite and Microbiome Interplay in Cancer Immunotherapy. Cancer Research 2016, 76: 6146-6152. PMID: 27729325, PMCID: PMC5093024, DOI: 10.1158/0008-5472.can-16-0309.Peer-Reviewed Original ResearchConceptsMicrobial interactionsRole of metabolitesCancer metabolismColon cancerHost microbiomeBiological originCancer progressionAdenoma/carcinomaPolysaccharide matrixTherapeutic designMetabolomic analysisPotential modulatorsMechanism of actionMicrobiomePolyamine metabolitesCancer immunotherapyBacteriaProximal colonBiofilmsProtective biofilmRecent studiesCancer treatmentMetabolismFuture targetsMetabolites
2013
Role of Gap Junctions and Hemichannels in Parasitic Infections
Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. Role of Gap Junctions and Hemichannels in Parasitic Infections. BioMed Research International 2013, 2013: 589130. PMID: 24236292, PMCID: PMC3819887, DOI: 10.1155/2013/589130.Peer-Reviewed Original ResearchConceptsForm gap junction channelsCell-cell interfaceDiverse physiologic processesGap junction channelsInvertebrate cellsVertebratesJunction channelsRole of CxsCell surfaceNew therapeutic designsPanx channelsHemichannelsGap junctionsTherapeutic designCellular communicationRecent findingsParasitic infectionsPhysiologic processesPathological statesPossible roleCxRecent evidenceInnexinsChannel typesPannexins
2008
Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment
Lemmon M. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. 2008 DOI: 10.21236/ada488172.Peer-Reviewed Original ResearchEGF receptor family membersEGF receptor signalingEGF-like ligandsReceptor family membersNew structural informationFruit flyYeast surface displayEGF receptorEGFR ligandsSecreted inhibitorsProtein scaffoldsReceptor signalingFunctional fragmentsSurface displayHuman EGFProtein therapeuticsTherapeutic designGrowth factorStructural informationNew therapeuticsExperimental approachStructure determinationFamily membersDrosophilaReceptors
2007
Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment
Lemmon M. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. 2007 DOI: 10.21236/ada471085.Peer-Reviewed Original ResearchEGF receptor family membersEGF receptor signalingEGF-like ligandsReceptor family membersNew structural informationFruit flyYeast surface displayEGF receptorSecreted inhibitorsEGFR ligandsProtein scaffoldsReceptor signalingFunctional fragmentsSurface displayHuman EGFProtein therapeuticsTherapeutic designGrowth factorNew therapeuticsStructural informationExperimental approachStructure determinationFamily membersDrosophilaReceptors
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