2024
The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis
McCool M, Bryant C, Abriola L, Surovtseva Y, Baserga S. The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis. PLOS Biology 2024, 22: e3002718. PMID: 38976757, PMCID: PMC11257408, DOI: 10.1371/journal.pbio.3002718.Peer-Reviewed Original ResearchRibosome biogenesis factorsRibosome biogenesisBiogenesis factorsCell growthNucleolar functionRegulation of nucleolar functionHuman ribosome biogenesisProtein synthesisProduction of ribosomesFamily of proteinsSource of mutagenesisLevel of protein synthesisCytidine deaminase familyIncreased cell growthPromote cell growthPre-rRNAPotential direct rolePre-mRNATransient overexpressionRibosomeGenomic mutationsBiogenesisMCF10A cellsMaturation stepsAPOBEC3A
2018
PO-136 Studying pathway interactions and dynamics to predict cell responses to chemotherapeutic treatment in breast cancer cells
Tuffery L, Kholodenko B, Kolch W, Halasz M, Fey D. PO-136 Studying pathway interactions and dynamics to predict cell responses to chemotherapeutic treatment in breast cancer cells. ESMO Open 2018, 3: a279-a280. DOI: 10.1136/esmoopen-2018-eacr25.660.Peer-Reviewed Original ResearchBreast cancer cell linesDoxorubicin treatmentCancer cell linesCell linesDifferent breast cancer cell linesBreast cancer cellsMCF10A cellsDifferent mutation patternsMechanism of actionPhosphorylation of JNKBreast cancer tumor samplesCommon cancerPatient responseTreatment strategiesBreast cancerTreatment responseChemotherapeutic treatmentCell responsesFlow cytometryTumor samplesWestern blotNon-cancerous cellsChemotherapeutic drugsPathway interactionsCancer cells
2014
Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells
Wali VB, Haskins JW, Gilmore-Hebert M, Platt JT, Liu Z, Stern DF. Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells. Molecular Cancer Research 2014, 12: 1140-1155. PMID: 24829397, PMCID: PMC4728083, DOI: 10.1158/1541-7786.mcr-13-0637.Peer-Reviewed Original ResearchConceptsYAP/Hippo pathwayIsogenic MCF10A cellsMultiple structural isoformsAlternative mRNA splicingDivergent cellular responsesChIP-seq experimentsProteases/protease inhibitorsErbB4 isoformsMammary epithelial cellsAssociation of ErbB4Hippo pathwayMRNA splicingNovel molecular targetsTranscriptional profilingDivergent functionsTranscription factorsCYT-1Signaling activitiesMevalonate pathwayCellular responsesLuminal breast cancer cell linesDiverse biologic activitiesMCF10A cellsCYT-2Intracellular isoformsThe DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers
Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene 2014, 34: 2325-2336. PMID: 24954505, PMCID: PMC4275425, DOI: 10.1038/onc.2014.173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationChromosomal Proteins, Non-HistoneDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansMiceNeoplasms, ExperimentalOncogene ProteinsPoly-ADP-Ribose Binding ProteinsReceptor Protein-Tyrosine KinasesWnt Signaling PathwayConceptsRon receptor activationΒ-catenin signalingBreast cancerReceptor activationSecretion of WntHuman mammary epithelial MCF10A cellsCanonical β-cateninWnt/β-catenin signalingΒ-catenin activityBreast cancer oncogeneΒ-catenin nuclear translocationReceptor-positive breast cancerEtiology of recurrentMetastatic breast cancerCancer stem cell markersBreast cancer patientsTumorigenic phenotypeBreast cancer progressionDownstream targetsStem cell markersCellular growthParacrine WntHuman diseasesMCF10A cellsRon receptor
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