2014
The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers
Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene 2014, 34: 2325-2336. PMID: 24954505, PMCID: PMC4275425, DOI: 10.1038/onc.2014.173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationChromosomal Proteins, Non-HistoneDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansMiceNeoplasms, ExperimentalOncogene ProteinsPoly-ADP-Ribose Binding ProteinsReceptor Protein-Tyrosine KinasesWnt Signaling PathwayConceptsRon receptor activationΒ-catenin signalingBreast cancerReceptor activationSecretion of WntHuman mammary epithelial MCF10A cellsCanonical β-cateninWnt/β-catenin signalingΒ-catenin activityBreast cancer oncogeneΒ-catenin nuclear translocationReceptor-positive breast cancerEtiology of recurrentMetastatic breast cancerCancer stem cell markersBreast cancer patientsTumorigenic phenotypeBreast cancer progressionDownstream targetsStem cell markersCellular growthParacrine WntHuman diseasesMCF10A cellsRon receptor
2011
Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear β-Catenin in Zebrafish*
Li Y, Li Q, Long Y, Cui Z. Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear β-Catenin in Zebrafish*. Journal Of Biological Chemistry 2011, 286: 45116-45130. PMID: 22057270, PMCID: PMC3248021, DOI: 10.1074/jbc.m111.267328.Peer-Reviewed Original ResearchConceptsCE movementsDorsoventral patterningMidline convergenceΒ-cateninNuclear β-cateninEmbryonic cell movementsWnt/β-catenin activityActivation of BMPΒ-catenin activityOrgan precursorsVertebrate embryogenesisActivation of STAT3Zygotic expressionBMP signalingRedundant functionsMidline progenitorsZebrafish embryosEarly embryosCell movementOrgan progenitorsEctopic expressionEmbryonic cellsVentralized embryosCanonical WntLZTS2
2010
Exosome‐release of beta‐catenin: A novel mechanism to antagonize Wnt signaling
Chairoungdua A, Smith D, Pochard P, Hull M, Caplan M. Exosome‐release of beta‐catenin: A novel mechanism to antagonize Wnt signaling. The FASEB Journal 2010, 24: 715.3-715.3. DOI: 10.1096/fasebj.24.1_supplement.715.3.Peer-Reviewed Original ResearchWnt/β-cateninWnt/β-catenin activityDendritic cellsΒ-cateninΒ-catenin activityCD9 expressionE-cadherinTumor metastasisWild-type miceNovel mechanismΒ-catenin protein levelsT cellsΒ-catenin levelsKnockout miceTumor cell metastasisCell metastasisGSK-3βMetastasisCHO cellsLuciferase reporterInappropriate activationCD82 expressionProtein levelsHEK 293T cellsSignificant decrease
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