The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers
Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene 2014, 34: 2325-2336. PMID: 24954505, PMCID: PMC4275425, DOI: 10.1038/onc.2014.173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationChromosomal Proteins, Non-HistoneDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansMiceNeoplasms, ExperimentalOncogene ProteinsPoly-ADP-Ribose Binding ProteinsReceptor Protein-Tyrosine KinasesWnt Signaling PathwayConceptsRon receptor activationΒ-catenin signalingBreast cancerReceptor activationSecretion of WntHuman mammary epithelial MCF10A cellsCanonical β-cateninWnt/β-catenin signalingΒ-catenin activityBreast cancer oncogeneΒ-catenin nuclear translocationReceptor-positive breast cancerEtiology of recurrentMetastatic breast cancerCancer stem cell markersBreast cancer patientsTumorigenic phenotypeBreast cancer progressionDownstream targetsStem cell markersCellular growthParacrine WntHuman diseasesMCF10A cellsRon receptor
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