2023
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances
Huang G, Jian J, Liu C. Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances. Cytokine & Growth Factor Reviews 2023, 76: 142-159. PMID: 37981505, PMCID: PMC10978308, DOI: 10.1016/j.cytogfr.2023.11.001.Peer-Reviewed Original ResearchDiverse functionsRegulation of tumorigenesisChaperone activityMultiple membrane receptorsMultitude of processesGrowth factor-like moleculesExtracellular functionsNeuronal degenerative diseasesLysosomal proteinsIntricate mechanismsLysosomal functionMembrane receptorsIntracellular componentsLysosomal hydrolasesDiverse arrayLysosomal storage diseaseProteinNeural proliferationGRN geneCritical roleGrowth factorIntricate interplayRole of progranulinPathophysiological processesStorage disease
2012
Science Signaling Podcast: 12 June 2012
Ferguson S, VanHook A. Science Signaling Podcast: 12 June 2012. Science Signaling 2012, 5 DOI: 10.1126/scisignal.2003263.Commentaries, Editorials and LettersTranscription factorsLysosomal homeostasisNuclear translocationActivity of TFEBExpression of genesDamaged organellesKinase mTORTFEB activityCell physiologyLysosomal proteinsLysosomal stressCellular wasteLysosomal functionTFEBInternalized materialScience SignalingMTOROrganellesTranslocationHomeostasisNormal conditionsDephosphorylationGenesSignalingCytoplasm
2011
A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes
Daniele T, Hackmann Y, Ritter A, Wenham M, Booth S, Bossi G, Schintler M, Auer‐Grumbach M, Griffiths G. A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes. Traffic 2011, 12: 902-911. PMID: 21438969, PMCID: PMC4116565, DOI: 10.1111/j.1600-0854.2011.01194.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCytoskeletal ProteinsDyneinsGuanosine TriphosphateHeLa CellsHumansLysosomesMiceMice, Inbred C57BLMicrotubule-Associated ProteinsMutationrab GTP-Binding Proteinsrab7 GTP-Binding ProteinsRecombinant Fusion ProteinsRNA InterferenceSecretory VesiclesT-Lymphocytes, CytotoxicConceptsSecretory lysosomesRab-interacting lysosomal proteinImmunological synapseGTP-bound Rab7Movement of secretory granulesMinus-end motorsPolarized secretionMinus endsLysosomal proteinsMolecular machineryRab7RNA interferenceRILPSecretory granulesLysosomal movementLysosomesOver-expressionTumorigenic cellsRecognition of target cellsCytotoxic T lymphocytesDyneinCentrosomeTarget cellsRabCells
2007
Gaucher Disease: Forging a New Path to the Lysosome
Griffiths G. Gaucher Disease: Forging a New Path to the Lysosome. Cell 2007, 131: 647-649. PMID: 18022357, DOI: 10.1016/j.cell.2007.10.043.Peer-Reviewed Original Research
1993
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.
Griffiths G, Isaaz S. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. Journal Of Cell Biology 1993, 120: 885-896. PMID: 8432729, PMCID: PMC2200067, DOI: 10.1083/jcb.120.4.885.Peer-Reviewed Original ResearchConceptsMan-6-PMannose-6-phosphateLytic granulesReceptor-independent pathwayI-cellEndo HEndoglycosidase H (endo HMan-6-P receptorSecretory rolePathway to lysosomesMannose-6-phosphate receptorMan-6-P residuesNormal cellsOligosaccharide side chainsGranzyme ACloned cytolytic T cell linesLysosomal proteinsGranule componentsI-cell diseaseLytic proteinsRadioactive phosphateEnzymatic substrateCytolytic T cell linesT cell linesCell fraction
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