2005
Coexpression of β1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome
Siddiqui SF, Pawelek J, Handerson T, Lin CY, Dickson RB, Rimm DL, Camp RL. Coexpression of β1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 2517-2523. PMID: 16284372, DOI: 10.1158/1055-9965.epi-05-0464.Peer-Reviewed Original ResearchConceptsSubstrate proteinsEpidermal growth factor receptorGrowth factor receptorLAMP-1Glycoprotein substratesFactor receptorComplex oligosaccharide side chainsN-cadherin expressionTumor progressionOligosaccharide side chainsBeta1 integrin expressionGnT-VN-cadherinUnsupervised hierarchical clusteringN-acetylglucosaminyltransferaseMatriptaseDistinct clustersProteinProtein expressionTumor metastasisExpressionHigh expressionAggressive breast cancerLow expressionSide chains
1993
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.
Griffiths G, Isaaz S. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. Journal Of Cell Biology 1993, 120: 885-896. PMID: 8432729, PMCID: PMC2200067, DOI: 10.1083/jcb.120.4.885.Peer-Reviewed Original ResearchConceptsMan-6-PMannose-6-phosphateLytic granulesReceptor-independent pathwayI-cellEndo HEndoglycosidase H (endo HMan-6-P receptorSecretory rolePathway to lysosomesMannose-6-phosphate receptorMan-6-P residuesNormal cellsOligosaccharide side chainsGranzyme ACloned cytolytic T cell linesLysosomal proteinsGranule componentsI-cell diseaseLytic proteinsRadioactive phosphateEnzymatic substrateCytolytic T cell linesT cell linesCell fraction
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