A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes
Daniele T, Hackmann Y, Ritter A, Wenham M, Booth S, Bossi G, Schintler M, Auer‐Grumbach M, Griffiths G. A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes. Traffic 2011, 12: 902-911. PMID: 21438969, PMCID: PMC4116565, DOI: 10.1111/j.1600-0854.2011.01194.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCytoskeletal ProteinsDyneinsGuanosine TriphosphateHeLa CellsHumansLysosomesMiceMice, Inbred C57BLMicrotubule-Associated ProteinsMutationrab GTP-Binding Proteinsrab7 GTP-Binding ProteinsRecombinant Fusion ProteinsRNA InterferenceSecretory VesiclesT-Lymphocytes, CytotoxicConceptsSecretory lysosomesRab-interacting lysosomal proteinImmunological synapseGTP-bound Rab7Movement of secretory granulesMinus-end motorsPolarized secretionMinus endsLysosomal proteinsMolecular machineryRab7RNA interferenceRILPSecretory granulesLysosomal movementLysosomesOver-expressionTumorigenic cellsRecognition of target cellsCytotoxic T lymphocytesDyneinCentrosomeTarget cellsRabCells
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