Associations of cerebral amyloid beta and tau with cognition from midlife
Gonzales M, O'Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimer's & Dementia 2024, 20: 5901-5911. PMID: 39039896, PMCID: PMC11497641, DOI: 10.1002/alz.14060.Peer-Reviewed Original ResearchApolipoprotein E e4Associated with cognitionTau positron emission tomographyPositron emission tomographyWorsening cognitionCommunity-based cohortYoung adultsApolipoprotein EStudy investigated associationsPoor visuospatial skillsDementia preventionTargeted early interventionE4 statusCerebral amyloid-betaEffect modifiersHigher amyloidAPOE e4 carriersCognitive vulnerabilityAssociation of amyloidVisuospatial skillsResilience factorsEarly interventionYounger ageCognitionE4 carriersAmyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes
Lesman-Segev O, Golan Shekhtman S, Springer R, Livny A, Lin H, Yuxia O, Zadok M, Ganmore I, Heymann A, Hoffmann C, Domachevsky L, Schnaider Beeri M. Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes. Scientific Reports 2024, 14: 2741. PMID: 38302529, PMCID: PMC10834442, DOI: 10.1038/s41598-024-53043-x.Peer-Reviewed Original ResearchConceptsNon-demented older adultsCognitive functionLower cognitive functionAmyloid burdenCognitive declineOlder adultsAssociations of small vessel diseaseAssociated with cognitive functionCognitive Decline studyAssociated with lower cognitive functionTreating cognitive declineAssociated with cognitive declineType 2 diabetesGray matterAssociation of amyloidIsrael DiabetesGM volumeAssess cognitionMeasures of small vessel diseaseWhite matter hyperintensitiesAlzheimer's disease biomarkersCognitionDecline studiesSmall vessel diseaseDiabetes-related characteristics
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