2022
Oxidative Stress in Traumatic Brain Injury
Fesharaki-Zadeh A. Oxidative Stress in Traumatic Brain Injury. International Journal Of Molecular Sciences 2022, 23: 13000. PMID: 36361792, PMCID: PMC9657447, DOI: 10.3390/ijms232113000.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAntioxidant therapyBrain injuryClinical settingPost-traumatic brain injuryOxidative stressReactive oxygen speciesUnderlying pathophysiological mechanismsSecondary injury cascadePromising treatment optionLipid peroxidation productsFree radical generating enzymesReal clinical settingNeurometabolic cascadeFree radical scavengerInjury cascadeChronic inflammationPathophysiological mechanismsSynaptic dysfunctionPost injuryTreatment optionsTBI treatmentSide effectsTBI symptomsInjury
2009
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.Peer-Reviewed Original ResearchConceptsAsthmatic airway inflammationAirway inflammationAirway hyperreactivityAllergen challengeHC-030031Airway allergen challengeEndogenous TRPA1 agonistsMurine ovalbumin modelImpaired inflammatory responseTreatment of asthmaRole of TRPA1Wild-type miceAirway epithelial functionAllergic inflammatory conditionsPromising pharmacological targetNeuronal ion channelsLipid peroxidation productsIon channelsAllergic asthmaAirway exposureEosinophil infiltrationLeukocyte infiltrationContractile stimuliInflammatory disordersOvalbumin modelDecreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1
Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseAirway inflammationOvalbumin-induced airway inflammationOvalbumin mouse modelAllergic airway inflammationObstructive pulmonary diseaseTRPA1-deficient miceChronic inflammatory statePeripheral sensory neuronsBronchoalveolar lavage fluidPro-inflammatory peptidesTh2-derived cytokinesIon channel TRPA1Lipid peroxidation productsAirway conditionsEosinophil infiltrationInflammatory mediatorsPulmonary diseaseNeuronal releaseAirway constrictionInflammatory stateLavage fluidVascular leakageEdema formationInflammatory process
1991
Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses
Mohsenin V. Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses. Journal Of Applied Physiology 1991, 70: 1456-1462. PMID: 2055821, DOI: 10.1152/jappl.1991.70.4.1456.Peer-Reviewed Original ResearchConceptsElastase inhibitory capacityAlveolar lining fluidLipid peroxidation productsLining fluidLavage fluidVitamin-supplemented groupOxidant stressLipid peroxidationPeroxidation productsControl groupLower respiratory tract fluidFour-week supplementationVitamin CRespiratory tract fluidNO2 exposureInactivation of alphaConjugated dienesVitamin supplementationNormal subjectsAntielastase activityInhibitory capacityOxidant exposureSignificant decreaseAntioxidant defensePeroxidation
1989
Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products
Mohsenin V, Gee J. Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. Journal Of Applied Physiology 1989, 66: 2211-2215. PMID: 2787317, DOI: 10.1152/jappl.1989.66.5.2211.Peer-Reviewed Original ResearchMeSH Keywordsalpha 1-AntitrypsinAntioxidantsBlood ProteinsDithiothreitolHumansKineticsLinoleic AcidLinoleic AcidsLipid BilayersLipid PeroxidationLipid PeroxidesMagnesiumMagnesium ChlorideMethionine Sulfoxide ReductasesOxidation-ReductionOxidoreductasesPancreatic ElastaseProtease InhibitorsStearic AcidsConceptsInhibitory capacityBronchoalveolar lavage fluidElastase inhibitory capacityLipid peroxidation productsElastase inhibitory activityMethionine sulfoxide peptide reductaseLinoleic acidLavage fluidVivo exposureAlpha-tocopherolOxidation of alphaPeroxidation productsGlutathione peroxidaseInhibitory effectLipid peroxidationAlphaInhibitory activityExogenous oxidantsInhibitorsVivoLipidsInhibitory siteStearic acid
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