2003
Role of the DPC4 Tumor Suppressor Gene in Adenocarcinoma of the Ampulla of Vater: Analysis of 140 Cases
McCarthy D, Hruban R, Argani P, Howe J, Conlon K, Brennan M, Zahurak M, Wilentz R, Cameron J, Yeo C, Kern S, Klimstra D. Role of the DPC4 Tumor Suppressor Gene in Adenocarcinoma of the Ampulla of Vater: Analysis of 140 Cases. Modern Pathology 2003, 16: 272-278. PMID: 12640108, DOI: 10.1097/01.mp.0000057246.03448.26.Peer-Reviewed Original ResearchConceptsLoss of Dpc4 expressionDpc4 expressionK-ras gene mutationAmpulla of VaterK-ras oncogeneK-rasPancreatic adenocarcinomaAreas of high-grade dysplasiaGene mutationsDPC4 tumor suppressor genesAssociated with shorter survivalDPC4 gene productLoss of DPC4Resected ampullary adenocarcinomaHigh-grade dysplasiaPredictor of prognosisDevelopment of adenocarcinomaLymph node metastasisActivating point mutationsIntestinal-type tumorsTumor suppressor geneK-ras geneComplete lossInvasive carcinomaAmpullary adenocarcinoma
2001
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
Fisher G, Wellen S, Klimstra D, Lenczowski J, Tichelaar J, Lizak M, Whitsett J, Koretsky A, Varmus H. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes & Development 2001, 15: 3249-3262. PMID: 11751631, PMCID: PMC312852, DOI: 10.1101/gad.947701.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenomaAnimalsApoptosisBromodeoxyuridineCyclin-Dependent Kinase Inhibitor p16DNA PrimersGene Expression Regulation, NeoplasticGenes, rasGenes, Tumor SuppressorGenotypeIn Situ Nick-End LabelingLung NeoplasmsMiceMice, KnockoutMice, TransgenicModels, GeneticNeoplasm Recurrence, LocalReverse Transcriptase Polymerase Chain ReactionTetracyclineTransgenesTumor Suppressor Protein p53ConceptsTumor suppressor geneType II pneumocytesApoptotic regressionLung adenocarcinomaProliferative lesionsPresence of tumor suppressor genesSuppressor geneHistological features of malignancyActivated K-ras geneK-rasControl of doxycyclineFeatures of malignancyViability of tumor cellsFocal proliferative lesionsAlveolar type II pneumocytesK-ras geneEarly proliferative lesionsMonths of inductionMutant K-rasMagnetic resonance imagingTumor burdenPulmonary tumorsP53 geneFocal invasionTumor cellsColloid (Mucinous Noncystic) Carcinoma of the Pancreas
Adsay N, Pierson C, Sarkar F, Abrams J, Weaver D, Conlon K, Brennan M, Klimstra D. Colloid (Mucinous Noncystic) Carcinoma of the Pancreas. The American Journal Of Surgical Pathology 2001, 25: 26-42. PMID: 11145249, DOI: 10.1097/00000478-200101000-00003.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmOrdinary ductal adenocarcinomaMucinous cystic neoplasmsLymph node metastasisMucinous cystadenocarcinomaDuctal adenocarcinomaIncisional biopsyColloid carcinomaK-ras genePerineurial invasionNode metastasisCodon 12Clinicopathological characteristics of CCPatients died of diseaseRegional lymph node metastasisK-rasSignet-ring cell adenocarcinomaBasal aspectDied of thromboembolismFive-year survivalPapillary mucinous neoplasmSignet-ring cellsPools of mucinPrognosis of CCIncidence of mutations
1996
Detection of rare circulating human colon tumor cells in a nude mouse xenograft model
Pages J, Sordat B, Bautista D, Costa J, Benhattar J. Detection of rare circulating human colon tumor cells in a nude mouse xenograft model. Cancer Letters 1996, 106: 139-144. PMID: 8827058, DOI: 10.1016/0304-3835(96)04319-4.Peer-Reviewed Original ResearchConceptsHuman colon tumor cellsTumor cellsColon tumor cellsSensitive allele-specific polymerase chain reactionExperimental modelNude mouse xenograft modelK-ras mutationsMouse xenograft modelAllele-specific polymerase chain reactionK-ras geneLymph nodesPrimary implantationSpecific polymerase chain reactionHuman colon carcinoma cellsMicrometastatic depositsPolymerase chain reactionColon carcinoma cellsXenograft modelNude miceGAT mutationMetastatic processCarcinoma cellsBloodChain reactionOccurrence of cells
1994
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Chaubert P, Benhattar J, Saraga E, Costa J. K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. American Journal Of Pathology 1994, 144: 767-75. PMID: 8160776, PMCID: PMC1887244.Peer-Reviewed Original ResearchConceptsK-ras mutationsLongstanding ulcerative colitisUlcerative colitisP53 alterationsActive colitisDysplastic lesionsK-rasGenetic alterationsP53 gene alterationsP53 genetic alterationsCombination of immunohistochemistryK-ras geneNonneoplastic lesionsColorectal carcinomaInvasive carcinomaColonic carcinomaDysplastic mucosaEpithelial lesionsInvasive tumorsColitisSame patientCarcinomaSporadic carcinomasLesionsNontumor samples
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1990
Genetic Abnormalities in Sporadic Parathyroid Adenomas
Friedman E, Bale A, Marx S, Norton J, Arnold A, Tu T, Aurbach G, Spiegel A. Genetic Abnormalities in Sporadic Parathyroid Adenomas. The Journal Of Clinical Endocrinology & Metabolism 1990, 71: 293-297. PMID: 2199477, DOI: 10.1210/jcem-71-2-293.Peer-Reviewed Original Research
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