2014
Adenocarcinoma of the Minor Duodenal Papilla and Its Precursor Lesions
Shia J, Agaram N, Olgac S, Cobanov B, Adsay V, Klimstra D. Adenocarcinoma of the Minor Duodenal Papilla and Its Precursor Lesions. The American Journal Of Surgical Pathology 2014, 38: 526-533. PMID: 24625417, DOI: 10.1097/pas.0000000000000123.Peer-Reviewed Original ResearchConceptsMinor papillaPrecursor lesionsMinor duodenal papillaPatients died of diseaseDuodenal papillaLoss of DPC4Pancreatobiliary-type carcinomasPancreatobiliary-type tumorsEvidence of diseaseMucinous-type tumorsAmpulla of VaterIntestinal-type carcinomasDNA mismatch repair deficiencyFollow-up informationDuct of SantoriniGermline mutation testingPatient diedRare tumorAccessory pancreatic ductDNA mismatch repair protein expressionMismatch repair deficiencyTumor sizePapilla carcinomaAdjacent duodenal mucosaPancreatic carcinoma
2003
Immunohistochemical and Genetic Analysis of Non–Small Cell and Small Cell Gallbladder Carcinoma and Their Precursor Lesions
Parwani A, Geradts J, Caspers E, Offerhaus G, Yeo C, Cameron J, Klimstra D, Maitra A, Hruban R, Argani P. Immunohistochemical and Genetic Analysis of Non–Small Cell and Small Cell Gallbladder Carcinoma and Their Precursor Lesions. Modern Pathology 2003, 16: 299-308. PMID: 12692194, DOI: 10.1097/01.mp.0000062656.60581.aa.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCarcinomaCyclin-Dependent Kinase Inhibitor p16Disease ProgressionDNA, NeoplasmDNA-Binding ProteinsFemaleGallbladder DiseasesGallbladder NeoplasmsGene Expression Regulation, NeoplasticGenes, rasHumansImmunohistochemistryMaleMiddle AgedMutationPolymerase Chain ReactionPrecancerous ConditionsSmad4 ProteinTrans-ActivatorsTumor Suppressor Protein p53ConceptsK-ras mutationsActivating K-ras mutationsSmall cell carcinomaGallbladder carcinomaLevels of p53Cell carcinomaP16 expressionPRb expressionLoss of Dpc4 expressionLoss of p16 expressionPRb tumor suppressor genesK-ras oncogene mutationsLoss of DPC4Loss of pRb expressionCarcinoma in situNon-small cellInactivation of p16Tumor suppressor geneIn situ componentInvasive gallbladder carcinomaMinority of casesDPC4 inactivationDpc4 expressionInvasive componentGenetic analysisRole of the DPC4 Tumor Suppressor Gene in Adenocarcinoma of the Ampulla of Vater: Analysis of 140 Cases
McCarthy D, Hruban R, Argani P, Howe J, Conlon K, Brennan M, Zahurak M, Wilentz R, Cameron J, Yeo C, Kern S, Klimstra D. Role of the DPC4 Tumor Suppressor Gene in Adenocarcinoma of the Ampulla of Vater: Analysis of 140 Cases. Modern Pathology 2003, 16: 272-278. PMID: 12640108, DOI: 10.1097/01.mp.0000057246.03448.26.Peer-Reviewed Original ResearchConceptsLoss of Dpc4 expressionDpc4 expressionK-ras gene mutationAmpulla of VaterK-ras oncogeneK-rasPancreatic adenocarcinomaAreas of high-grade dysplasiaGene mutationsDPC4 tumor suppressor genesAssociated with shorter survivalDPC4 gene productLoss of DPC4Resected ampullary adenocarcinomaHigh-grade dysplasiaPredictor of prognosisDevelopment of adenocarcinomaLymph node metastasisActivating point mutationsIntestinal-type tumorsTumor suppressor geneK-ras geneComplete lossInvasive carcinomaAmpullary adenocarcinoma
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