2023
Somatic loss of ATM is a late event in pancreatic tumorigenesis
Paranal R, Jiang Z, Hutchings D, Kryklyva V, Gauthier C, Fujikura K, Nanda N, Huang B, Skaro M, Wolfgang C, He J, Klimstra D, Brand R, Singhi A, DeMarzo A, Zheng L, Goggins M, Brosens L, Hruban R, Klein A, Lotan T, Wood L, Roberts N. Somatic loss of ATM is a late event in pancreatic tumorigenesis. The Journal Of Pathology 2023, 260: 455-464. PMID: 37345735, PMCID: PMC10524278, DOI: 10.1002/path.6136.Peer-Reviewed Original ResearchConceptsGermline ATM variantsPancreatic precursor lesionsATM variantsPrecursor lesionsPancreatic ductal adenocarcinomaInvasive pancreatic adenocarcinomaATM statusATM alterationsPancreatic adenocarcinomaColloid carcinomaDuctal adenocarcinomaPancreatic tumorigenesisATM expressionInvasive pancreatic ductal adenocarcinomaSpectrum of genetic alterationsDevelopment of pancreatic cancerLoss of protein expressionLesions of patientsLoss of ATM expressionLoss of ATMPancreatic cancerSomatic lossGenetic alterationsAdenocarcinomaPatients
2011
Invasive Carcinoma Arising in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Yopp A, Katabi N, Janakos M, Klimstra D, D'Angelica M, DeMatteo R, Fong Y, Brennan M, Jarnagin W, Allen P. Invasive Carcinoma Arising in Intraductal Papillary Mucinous Neoplasms of the Pancreas. Annals Of Surgery 2011, 253: 968-974. PMID: 21422912, DOI: 10.1097/sla.0b013e318214bcb4.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, MucinousAdenocarcinoma, PapillaryAdultAgedAged, 80 and overBiopsy, NeedleCarcinoma, Pancreatic DuctalCase-Control StudiesChi-Square DistributionDisease-Free SurvivalFemaleFollow-Up StudiesHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessPancreatectomyPostoperative ComplicationsProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsIntraductal papillary mucinous neoplasmDuctal pancreatic adenocarcinomaColloid carcinomaPapillary mucinous neoplasmTubular carcinomaInvasive carcinomaPancreatic adenocarcinomaTubular subtypeHistological subtypesInvasive componentConventional adenocarcinomaMucinous neoplasmsSurvival outcomesPresence of positive regional lymph nodesFactors predictive of decreased survivalPredictive of decreased survivalPositive regional lymph nodesSurvival rateConventional pancreatic adenocarcinomaLonger survival outcomesCohort of matched patientsFavorable survival outcomesSubtypes of invasive carcinomaDuctal pancreatic carcinomaRegional lymph nodes
2010
Preferential Expression of MUC6 in Oncocytic and Pancreatobiliary Types of Intraductal Papillary Neoplasms Highlights a Pyloropancreatic Pathway, Distinct From the Intestinal Pathway, in Pancreatic Carcinogenesis
Basturk O, Khayyata S, Klimstra D, Hruban R, Zamboni G, Coban I, Adsay N. Preferential Expression of MUC6 in Oncocytic and Pancreatobiliary Types of Intraductal Papillary Neoplasms Highlights a Pyloropancreatic Pathway, Distinct From the Intestinal Pathway, in Pancreatic Carcinogenesis. The American Journal Of Surgical Pathology 2010, 34: 364-370. PMID: 20139757, PMCID: PMC3160822, DOI: 10.1097/pas.0b013e3181cf8bb6.Peer-Reviewed Original ResearchConceptsIntestinal-type intraductal papillary mucinous neoplasmsIntraductal oncocytic papillary neoplasmMucinous cystic neoplasmsExpression of MUC6Ductal adenocarcinomaColloid carcinomaMUC6 expressionExpression profilesPreferential expressionCellular lineagesColumnar-cellIntestinal pathwayIntraductal papillary mucinous neoplasmDivergent pathwaysPathwayPositive surgical marginsInvasive ductal adenocarcinomaLymph node metastasisPapillary mucinous neoplasmExpressionMarker of aggressiveness
2004
Pathologically and Biologically Distinct Types of Epithelium in Intraductal Papillary Mucinous Neoplasms
Adsay N, Merati K, Basturk O, Iacobuzio-Donahue C, Levi E, Cheng J, Sarkar F, Hruban R, Klimstra D. Pathologically and Biologically Distinct Types of Epithelium in Intraductal Papillary Mucinous Neoplasms. The American Journal Of Surgical Pathology 2004, 28: 839-848. PMID: 15223952, DOI: 10.1097/00000478-200407000-00001.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, MucinousBile Duct NeoplasmsBiomarkers, TumorCarcinoma in SituCarcinoma, Pancreatic DuctalCarcinoma, PapillaryCDX2 Transcription FactorCell NucleusCell Transformation, NeoplasticEpitheliumHomeodomain ProteinsHumansImmunohistochemistryIntestinal NeoplasmsMembrane ProteinsMucin-2MucinsNeoplasm InvasivenessPancreatic NeoplasmsTranscription FactorsConceptsIntraductal papillary mucinous neoplasmCarcinoma in situPapillary mucinous neoplasmInvasive carcinomaMucinous neoplasmsExpressed CDX2Associated with invasive carcinomaBiologically distinct typeCharacteristics of intraductal papillary mucinous neoplasmsIntestinal differentiationAggressive clinical courseStratification of patientsGastric foveolar epitheliumPathways of carcinogenesisClinical courseCystic componentPancreatic tumorsBorderline atypiaColloid carcinomaBasally located nucleiPapillary neoplasmCDX2 expressionPapillary patternBiliary tractIntestinal-typeMUC1 and MUC2 in pancreatic neoplasia
Levi E, Klimstra D, Adsay N, Andea A, Basturk O. MUC1 and MUC2 in pancreatic neoplasia. Journal Of Clinical Pathology 2004, 57: 456. PMID: 15113850, PMCID: PMC1770304, DOI: 10.1136/jcp.2003.013292.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPancreatic neoplasiaMarker of aggressive phenotypeSpread of carcinoma cellsIntestinal IPMNsPapillary mucinous neoplasmAggressive pancreatic tumorsCell-stroma interactionsIndolent tumorsProtective barrier functionTumor suppressor roleIndolent phenotypePancreatic tumorsColloid carcinomaMucinous neoplasmsPrognostic valueVascular spreadAggressive phenotypeAggressive natureCell-cellCarcinoma cellsCancer progressionSignal transducerIndole pathwayNeoplasiaColloid carcinoma of the pancreas
Andea A, Klimstra D, Cheng J, Adsay N. Colloid carcinoma of the pancreas. Diagnostic Histopathology 2004, 10: 61-68. DOI: 10.1016/j.cdip.2003.09.007.Peer-Reviewed Original ResearchIntraductal papillary mucinous neoplasmColloid carcinomaPapillary mucinous neoplasmDuctal adenocarcinomaMucinous neoplasmsPresence of lymph node metastasisCarcinoma of ductal originOrdinary ductal adenocarcinomaOrdinary ductal carcinomaPancreatic colloid carcinomaConventional ductal adenocarcinomaMalignant epithelial cellsLymph node metastasisStroma-facing surfacePancreatic intraepithelial neoplasiaPools of mucinLonger survival ratesIndolent courseIntraepithelial neoplasiaMucinous carcinomaDuctal carcinomaMixed carcinomasIndolent natureConventional adenocarcinomaEpithelial elements
2003
Pathogenesis of Colloid (Pure Mucinous) Carcinoma of Exocrine Organs
Adsay V, Merati K, Nassar H, Shia J, Sarkar F, Pierson C, Cheng J, Visscher D, Hruban R, Klimstra D. Pathogenesis of Colloid (Pure Mucinous) Carcinoma of Exocrine Organs. The American Journal Of Surgical Pathology 2003, 27: 571-578. PMID: 12717243, DOI: 10.1097/00000478-200305000-00002.Peer-Reviewed Original ResearchConceptsStroma-facing surfaceDuctal carcinomaNormal ductsImmunohistochemical stainingMucigen granulesLakes of mucinConventional ductal carcinomaExocrine organsPoorly differentiated areasCell-stroma interactionsTumor suppressor activityCC cellsSurface glycoproteinColloid carcinomaExtracellular mucinConventional carcinomasMalignant cellsTumor cellsGrowth of CCBasal lamina formationExpression frequencyMUC2 expressionNormal tissuesStromaSuppressor activity
2002
The Dichotomy in the Preinvasive Neoplasia to Invasive Carcinoma Sequence in the Pancreas: Differential Expression of MUC1 and MUC2 Supports the Existence of Two Separate Pathways of Carcinogenesis
Adsay N, Merati K, Andea A, Sarkar F, Hruban R, Wilentz R, Goggins M, Iocobuzio-Donahue C, Longnecker D, Klimstra D. The Dichotomy in the Preinvasive Neoplasia to Invasive Carcinoma Sequence in the Pancreas: Differential Expression of MUC1 and MUC2 Supports the Existence of Two Separate Pathways of Carcinogenesis. Modern Pathology 2002, 15: 1087-1095. PMID: 12379756, DOI: 10.1097/01.mp.0000028647.98725.8b.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmExpression of MUC1Colloid carcinomaMucinous neoplasmsDuctal adenocarcinomaInvasive carcinomaCarcinoma sequenceInvasive ductal adenocarcinomaPancreatic intraepithelial neoplasmsPathways of carcinogenesisStudy of carcinogenesisGrade lesionsIntraepithelial neoplasmPancreas cancerCarcinomaNeoplasmsAdenocarcinomaImmunohistochemical labelingMUC1PancreasPanINMUC2Aggressive pathwayLesions
2001
Colloid Carcinoma of the Pancreas
Adsay N, Cheng J, Klimstra D, Pierson C. Colloid Carcinoma of the Pancreas. Advances In Anatomic Pathology 2001, 6: 115-120. DOI: 10.1097/00132583-200105000-00007.Peer-Reviewed Original ResearchColloid carcinomaDegree of mucin formationSignet-ring cell carcinomaIntraductal papillary mucinous neoplasmIndividual cell infiltrationTumors of ductal originSolid pancreatic massesLymph node metastasisPapillary mucinous neoplasmSignet-ring cellsTime of diagnosisMucinous cystic neoplasmsMucinous cystadenocarcinomaPerineurial invasionAbdominal painMucinous carcinomaInvasive carcinomaNoninvasive tumorsCell carcinomaClinical courseMucin poolsBack painClinical presentationOminous prognosisPancreatic massColloid (Mucinous Noncystic) Carcinoma of the Pancreas
Adsay N, Pierson C, Sarkar F, Abrams J, Weaver D, Conlon K, Brennan M, Klimstra D. Colloid (Mucinous Noncystic) Carcinoma of the Pancreas. The American Journal Of Surgical Pathology 2001, 25: 26-42. PMID: 11145249, DOI: 10.1097/00000478-200101000-00003.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmOrdinary ductal adenocarcinomaMucinous cystic neoplasmsLymph node metastasisMucinous cystadenocarcinomaDuctal adenocarcinomaIncisional biopsyColloid carcinomaK-ras genePerineurial invasionNode metastasisCodon 12Clinicopathological characteristics of CCPatients died of diseaseRegional lymph node metastasisK-rasSignet-ring cell adenocarcinomaBasal aspectDied of thromboembolismFive-year survivalPapillary mucinous neoplasmSignet-ring cellsPools of mucinPrognosis of CCIncidence of mutations
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