Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
Fisher G, Wellen S, Klimstra D, Lenczowski J, Tichelaar J, Lizak M, Whitsett J, Koretsky A, Varmus H. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes & Development 2001, 15: 3249-3262. PMID: 11751631, PMCID: PMC312852, DOI: 10.1101/gad.947701.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenomaAnimalsApoptosisBromodeoxyuridineCyclin-Dependent Kinase Inhibitor p16DNA PrimersGene Expression Regulation, NeoplasticGenes, rasGenes, Tumor SuppressorGenotypeIn Situ Nick-End LabelingLung NeoplasmsMiceMice, KnockoutMice, TransgenicModels, GeneticNeoplasm Recurrence, LocalReverse Transcriptase Polymerase Chain ReactionTetracyclineTransgenesTumor Suppressor Protein p53ConceptsTumor suppressor geneType II pneumocytesApoptotic regressionLung adenocarcinomaProliferative lesionsPresence of tumor suppressor genesSuppressor geneHistological features of malignancyActivated K-ras geneK-rasControl of doxycyclineFeatures of malignancyViability of tumor cellsFocal proliferative lesionsAlveolar type II pneumocytesK-ras geneEarly proliferative lesionsMonths of inductionMutant K-rasMagnetic resonance imagingTumor burdenPulmonary tumorsP53 geneFocal invasionTumor cells
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