Role of the DPC4 Tumor Suppressor Gene in Adenocarcinoma of the Ampulla of Vater: Analysis of 140 Cases
McCarthy D, Hruban R, Argani P, Howe J, Conlon K, Brennan M, Zahurak M, Wilentz R, Cameron J, Yeo C, Kern S, Klimstra D. Role of the DPC4 Tumor Suppressor Gene in Adenocarcinoma of the Ampulla of Vater: Analysis of 140 Cases. Modern Pathology 2003, 16: 272-278. PMID: 12640108, DOI: 10.1097/01.mp.0000057246.03448.26.Peer-Reviewed Original ResearchConceptsLoss of Dpc4 expressionDpc4 expressionK-ras gene mutationAmpulla of VaterK-ras oncogeneK-rasPancreatic adenocarcinomaAreas of high-grade dysplasiaGene mutationsDPC4 tumor suppressor genesAssociated with shorter survivalDPC4 gene productLoss of DPC4Resected ampullary adenocarcinomaHigh-grade dysplasiaPredictor of prognosisDevelopment of adenocarcinomaLymph node metastasisActivating point mutationsIntestinal-type tumorsTumor suppressor geneK-ras geneComplete lossInvasive carcinomaAmpullary adenocarcinoma
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