2023
Role of the immune-kynurenine pathway in treatment-resistant schizophrenia
Chen W, Tian Y, Gou M, Wang L, Tong J, Zhou Y, Feng W, Li Y, Chen S, Liu Y, Wang Z, Pan S, Zhang P, Huang J, Yang X, Li C, Tian L, Hong L, Tan Y. Role of the immune-kynurenine pathway in treatment-resistant schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 130: 110926. PMID: 38147973, DOI: 10.1016/j.pnpbp.2023.110926.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemTreatment-resistant schizophreniaQUIN/KYNA ratioNon-TRS patientsHealthy controlsKynurenine pathwayKP metabolismKP activationKynurenic acidQuinolinic acidInflammation-related effectsPeripheral immune responseAnti-inflammatory cytokinesPro-inflammatory cytokinesBinary logistic regression analysisPathophysiology of schizophreniaLogistic regression analysisAge of onsetLower kynurenineKP metabolitesKYNA levelsIllness onsetPlasma levelsRisk factorsNMDA receptors
2021
Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings
Noyan H, Erdağ E, Tüzün E, Yaylım İ, Küçükhüseyin Ö, Hakan M, Gülöksüz S, Rutten B, Saka M, Atbaşoğlu C, Alptekin K, van Os J, Üçok A. Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings. Schizophrenia Research 2021, 229: 27-37. PMID: 33609988, DOI: 10.1016/j.schres.2021.01.014.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersIL-1β levelsKYNA levelsHigher serum IL-1β levelsSerum IL-1β levelsHigher KYNA levelsTrp-Kyn pathwayKynurenic acid levelsSimilar clinical featuresPathophysiology of schizophreniaManifestations of schizophreniaKYN levelsSerum interleukinClinical featuresInflammatory cytokinesIL-1βClinical dataKynurenine pathwayTRP levelsSpectrum disorderControl groupAdvanced stageLow TrpPathway dysregulationPatients
2000
Nicotine‐induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid
Erhardt S, Hajos M, Lindberg A, Engberg G. Nicotine‐induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid. Synapse 2000, 37: 104-108. PMID: 10881031, DOI: 10.1002/1098-2396(200008)37:2<104::aid-syn4>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsEndogenous brain kynurenic acidCentral noradrenergic neuronsBrain kynurenic acidEndogenous kynurenic acidKynurenic acidNoradrenergic neuronsLocus coeruleusLevels of KYNAEndogenous glutamate receptor antagonistBrain KYNA levelsNicotine-induced excitationGlutamate receptor antagonistsLocus coeruleus neuronsAction of nicotineRelease of glutamatePresent electrophysiological studyGlutamatergic responsesKYNA levelsLC neuronsCoeruleus neuronsPeripheral originReceptor antagonistAnesthetized ratsElectrophysiological studiesLow doses
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply