2003
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal
Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, Wynick D, Langel Ü, Picciotto MR. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 9028-9033. PMID: 12853567, PMCID: PMC166432, DOI: 10.1073/pnas.1533224100.Peer-Reviewed Original ResearchConceptsMorphine withdrawal signsWithdrawal signsOpiate withdrawalGalanin agonistsEffects of galaninLocus coeruleus neuronsC-Fos immunoreactivityBlood-brain barrierEndogenous galaninMorphine withdrawalNoradrenergic neuronsCoeruleus neuronsC57BL/6 miceNeurochemical signsNeuropeptide galaninLocus coeruleusPossible molecular mechanismsTyrosine hydroxylaseGalaninNeuronal activityGalanin peptidePhysical signsTransgenic miceDrug dependenceBehavioral effects
2000
Nicotine‐induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid
Erhardt S, Hajos M, Lindberg A, Engberg G. Nicotine‐induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid. Synapse 2000, 37: 104-108. PMID: 10881031, DOI: 10.1002/1098-2396(200008)37:2<104::aid-syn4>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsEndogenous brain kynurenic acidCentral noradrenergic neuronsBrain kynurenic acidEndogenous kynurenic acidKynurenic acidNoradrenergic neuronsLocus coeruleusLevels of KYNAEndogenous glutamate receptor antagonistBrain KYNA levelsNicotine-induced excitationGlutamate receptor antagonistsLocus coeruleus neuronsAction of nicotineRelease of glutamatePresent electrophysiological studyGlutamatergic responsesKYNA levelsLC neuronsCoeruleus neuronsPeripheral originReceptor antagonistAnesthetized ratsElectrophysiological studiesLow doses
1996
Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats
Krystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.Peer-Reviewed Original ResearchConceptsL-type calcium channel antagonistLocus coeruleus neuronsMorphine-dependent ratsOpiate-dependent ratsCalcium channel antagonistsSingle-unit recordingsLocus coeruleus activationNimodipine effectCoeruleus neuronsNoradrenergic mechanismsOpiate withdrawalLocus coeruleusChannel antagonistsAnesthetized animalsNimodipineAbstinence behaviorTime courseRatsWithdrawal behaviorActivationNaltrexoneCoeruleus
1994
Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Widnell K, Russell D, Nestler E. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 10947-10951. PMID: 7971989, PMCID: PMC45143, DOI: 10.1073/pnas.91.23.10947.Peer-Reviewed Original ResearchConceptsLocus coeruleusCREB expressionCREB immunoreactivityCell linesChronic morphine administrationLocus coeruleus neuronsCRE-binding activityResponse element-binding proteinCAMP pathwayCREB mRNA levelsCAMP response element-binding proteinMorphine administrationChronic morphineCoeruleus neuronsBrain regionsCRE bindingOpiate addictionElement-binding proteinPC12 pheochromocytoma cellsCAMP response elementMRNA levelsPheochromocytoma cellsCoeruleusImmunoreactivityCREB mRNANicotine-induced activation of locus coeruleus neurons —an analysis of peripheral versus central induction
Engbergl G, Hajos M. Nicotine-induced activation of locus coeruleus neurons —an analysis of peripheral versus central induction. Naunyn-Schmiedeberg's Archives Of Pharmacology 1994, 349: 443-446. PMID: 8065457, DOI: 10.1007/bf00169131.Peer-Reviewed Original ResearchConceptsLocus coeruleus neuronsLC neuronsBaseline firing rateHigh dosesFiring rateCoeruleus neuronsNicotinic receptorsLow dosesElevated spontaneous firing ratesLow intravenous dosesMost LC neuronsPeripheral nicotinic receptorsNicotine-induced activationSpontaneous firing rateAdministration of nicotineCentral nicotinic receptorsAdministration of mecamylaminePrevious electrophysiological experimentsNicotine inducesIntravenous dosesPeripheral originSystemic administrationIntravenous administrationLC activationNeurons
1992
Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors
Engberg G, Hajós M. Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 1992, 346: 437-441. PMID: 1436128, DOI: 10.1007/bf00171087.Peer-Reviewed Original ResearchConceptsChronic ethanol treatmentExcitatory amino acid neurotransmissionExcitatory amino acid receptorsNoradrenergic locus coeruleus neuronsEthanol treatmentAmino acid neurotransmissionAmino acid receptorsLocus coeruleus neuronsEthanol-treated ratsMK-801 doseAlcohol withdrawal reactionsEAA receptorsEAA antagonistsLC neuronsCoeruleus neuronsClinical signsWithdrawal reactionsNeurons accountsAcid receptorsAbstinence reactionsElectrophysiological evidenceAdaptive changesTreatmentNeuronsReceptorsEthanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo
Engberg G, Hajós M. Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo. Naunyn-Schmiedeberg's Archives Of Pharmacology 1992, 345: 222-226. PMID: 1314963, DOI: 10.1007/bf00165740.Peer-Reviewed Original ResearchConceptsLocus coeruleus neuronsCoeruleus neuronsLocus coeruleus noradrenergic neuronsExcitatory amino acid agonistsLocus coeruleus responseAmino acid agonistsExcitatory amino acidsAdministration of ethanolExtracellular recording techniquesEffects of ethanolMicroiontophoretic applicationNoradrenergic neuronsGlutamate excitationHippocampal slicesLocus coeruleusEthanol intoxicationElectrophysiological studiesEthanol treatmentFiring patternsNeuronsRecording techniquesUnderlaying mechanismPresent studyVivoKainate
1991
Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration
Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.Peer-Reviewed Original ResearchConceptsAcid administrationKynurenic acidSubcutaneous administrationPeripheral excitatory amino acid receptorsExcitatory amino acid antagonist kynurenic acidExcitatory amino acid receptorsAntagonist kynurenic acidExcitatory amino acidsAmino acid receptorsLocus coeruleus neuronsMorphine-dependent ratsBlood-brain barrierSingle-unit recordingsMorphine withdrawalCoeruleus neuronsAntagonist treatmentAbstinence symptomsOpiate withdrawalUnit recordingsAnesthetized animalsAcid receptorsBehavioral signsAdministrationDifferential effectsWithdrawal
1987
Capsaicin‐induced excitation of locus coeruleus neurons
HAJÓS M, JANCSÓ G, ENGBERG G. Capsaicin‐induced excitation of locus coeruleus neurons. Acta Physiologica 1987, 129: 415-420. PMID: 3577824, DOI: 10.1111/j.1748-1716.1987.tb08086.x.Peer-Reviewed Original ResearchConceptsLocus coeruleusPrimary afferentsAdult ratsHigh dosesPontine nucleus locus coeruleusCapsaicin-induced excitationSigns of tachyphylaxisLocus coeruleus neuronsEffects of capsaicinNucleus locus coeruleusLC firing rateMarked excitationCoeruleus neuronsLC neuronsAnalgetic effectControl ratsLow dosesCapsaicinHistological dataElectrophysiological techniquesFiring rateSilver impregnation techniqueRatsSensory processingDoses
1986
Reduced responsiveness of locus coeruleus neurons to cutaneous thermal stimuli in capsaicin-treated rats
Hajós M, Engberg G, Elam M. Reduced responsiveness of locus coeruleus neurons to cutaneous thermal stimuli in capsaicin-treated rats. Neuroscience Letters 1986, 70: 382-387. PMID: 3022199, DOI: 10.1016/0304-3940(86)90584-7.Peer-Reviewed Original ResearchConceptsCutaneous thermal stimuliLocus coeruleusThermal stimuliBrain norepinephrine (NE) neuronsLocus coeruleus neuronsAfferent transmissionCapsaicin treatmentLC neuronsRecent electrophysiological experimentsCoeruleus neuronsNorepinephrine neuronsThermoregulatory dysfunctionAdult ratsImpaired thermoregulationNeuronal responsesReduced responsivenessNoxious characterCutaneous thermal sensitivityRatsElectrophysiological experimentsNeuronsCapsaicinPresent studyTreatmentResponsiveness
1978
Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism
Cedarbaum J, Aghajanian G. Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism. Life Sciences 1978, 23: 1383-1392. PMID: 214648, DOI: 10.1016/0024-3205(78)90398-3.Peer-Reviewed Original ResearchConceptsLocus coeruleusNerve stimulationLocus coeruleus neuronsRat locus coeruleusPeripheral nerve stimulationBursts of spikesNeuronal responsivityNoradrenergic neuronsCoeruleus neuronsAntidromic activationAxon collateralsAdrenergic antagonistsPutative transmittersNoxious stimuliPeripheral stimuliUnit firingReduced responsivityAutoinhibitory actionInhibitory mechanismPiperoxaneNeuronsAdditional stimulusStimulationCollateralsStimuli
1977
Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization
Cedarbaum J, Aghajanian G. Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization. European Journal Of Pharmacology 1977, 44: 375-385. PMID: 330174, DOI: 10.1016/0014-2999(77)90312-0.Peer-Reviewed Original ResearchConceptsLC neuronsLocus coeruleusNoradrenergic neuronsCatecholamine receptorsΑ-receptorsCell bodiesΑ-methylnorepinephrinePostsynaptic α-receptorsPeripheral sympathetic nervesLocus coeruleus neuronsDopamine agonist apomorphineCentral dopamine receptorsΒ-agonist isoproterenolSingle-unit recordingsSympathetic nervesAgonist apomorphineAgonist clonidineMicroiontophoretic applicationCoeruleus neuronsSpontaneous firingΑ-adrenoreceptorsDopamine receptorsPharmacological characterizationAgonist drugsPharmacological characteristics
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