2025
Midterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection
Hu K, Ma W, Pupovac S, Hameed I, Fereydooni S, Li E, Larson H, Zafar M, Tonnessen B, Cardella J, Aboian E, Guzman R, Chaar C, Strosberg D, Williams M, Nassiri N, Assi R, Vallabhajosyula P. Midterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection. JTCVS Open 2025, 24: 67-76. PMID: 40309678, PMCID: PMC12039393, DOI: 10.1016/j.xjon.2024.12.013.Peer-Reviewed Original ResearchThoracic endovascular aortic repairThoracic endovascular aortic repair groupOptimal medical therapyOptimal medical therapy groupMidterm outcomes of thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B aortic dissectionEndovascular aortic repairAcute kidney injuryAortic repairMidterm outcomesMedical therapyUncomplicated acute type B dissectionAcute type B aortic dissectionAcute type B dissectionAssociated with improved survivalType B aortic dissectionThirty-day ratesType B dissectionB aortic dissectionPost-operative dataMidterm follow-upIn-hospital/30-day mortalityKaplan-Meier survivalB dissection
2022
A population-based evaluation of tunica vaginalis mesothelioma: An analysis of the National Cancer Database
Witmer H, Dhiman A, Giurcanu M, Eng O, Eggener S, Kindler H, Turaga K. A population-based evaluation of tunica vaginalis mesothelioma: An analysis of the National Cancer Database. Urologic Oncology Seminars And Original Investigations 2022, 41: 52.e11-52.e20. PMID: 36319552, DOI: 10.1016/j.urolonc.2022.09.029.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseOverall survivalSystemic chemotherapyCancer DatabaseMargin-negative surgical resectionPositive surgical marginsAdjuvant systemic chemotherapyReceipt of systemic chemotherapyIncreased risk of deathQuartiles of ageKaplan-Meier survivalCox proportional hazards modelsRisk of deathPopulation-based evaluationProportional hazards modelMedian OSImproved OSMedian followPrimary mesotheliomaPropensity score matchingSurgical marginsSurgical resectionNo significant differenceHistology codesRetrospective analysis
2021
Contemporary outcomes of concomitant suprainguinal bypass with infrainguinal revascularization procedures in patients with chronic limb-threatening ischemia
Naazie I, Zarrintan S, Arhuidese I, Al-Nouri O, Abou-Zamzam A, Malas M. Contemporary outcomes of concomitant suprainguinal bypass with infrainguinal revascularization procedures in patients with chronic limb-threatening ischemia. Journal Of Vascular Surgery 2021, 75: 989-997.e1. PMID: 34606957, DOI: 10.1016/j.jvs.2021.08.105.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaRisk of amputationSuprainguinal bypassRest painAmputation-free survivalIncreased riskLimb-threatening ischemiaInfrainguinal revascularizationTissue lossMajor amputationInfrainguinal bypassRevascularization proceduresIncreased risk of amputationPerioperative myocardial infarction rateAssociated with decreased riskConcomitant infrainguinal bypassOutcomes of patientsLog-rank testPerioperative myocardial infarctionKaplan-Meier survivalTreatment of patientsVascular Quality InitiativeMyocardial infarction rateInfrainguinal revascularization proceduresIncreased oddsImpact of Neoantigen Expression and T-Cell Activation on Breast Cancer Survival
Li W, Amei A, Bui F, Norouzifar S, Lu L, Wang Z. Impact of Neoantigen Expression and T-Cell Activation on Breast Cancer Survival. Cancers 2021, 13: 2879. PMID: 34207556, PMCID: PMC8228363, DOI: 10.3390/cancers13122879.Peer-Reviewed Original ResearchT cell activationNeoantigen expressionChi-squared testOverall survivalBreast cancerMultivariable Cox proportional hazards modelsMultivariable Cox regression modelsCox proportional hazards modelImproved overall survivalT-cell statusT cell exhaustionBreast cancer patientsKaplan-Meier survivalBreast cancer survivalCox regression modelClinical-pathological variablesReceptor-positive subgroupCancer immunotherapy efficacyProportional hazards modelPearson's chi-squared testTumor-specific somatic mutationsSpearman correlation analysisImmunotherapy efficacyPathological variablesPatient survival
2020
Regulation and characterization of tumor-infiltrating immune cells in breast cancer
Dai Q, Wu W, Amei A, Yan X, Lu L, Wang Z. Regulation and characterization of tumor-infiltrating immune cells in breast cancer. International Immunopharmacology 2020, 90: 107167. PMID: 33223469, PMCID: PMC7855363, DOI: 10.1016/j.intimp.2020.107167.Peer-Reviewed Original ResearchConceptsTumor-infiltrating immune cellsT cell activation statusImmune cellsCell activation statusT cell activationPatient survivalM2 macrophagesT cellsBreast cancerCell activationT cell peripheral toleranceTumor-infiltrating B cellsMultivariate Cox regression modelActivation statusBreast cancer patient survivalEffector T cellsT cell subsetsBreast cancer patientsImmune cell infiltrationAbundant plasma cellsCox regression modelKaplan-Meier survivalImmune cell typesMolecular pathwaysCancer patient survivalA National Study of Surgically Managed Atypical Pulmonary Carcinoid Tumors
Walters SL, Canavan ME, Salazar MC, Resio BJ, Blasberg JD, Mase V, Boffa DJ. A National Study of Surgically Managed Atypical Pulmonary Carcinoid Tumors. The Annals Of Thoracic Surgery 2020, 112: 921-927. PMID: 33159862, DOI: 10.1016/j.athoracsur.2020.09.029.Peer-Reviewed Original ResearchConceptsAtypical pulmonary carcinoid tumorsPulmonary carcinoid tumorsCarcinoid tumorsCarcinoid patientsAtypical carcinoidStage IMultivariable Cox proportional hazards regressionNon-small cell lung cancerCox proportional hazards regressionAtypical carcinoid patientsTypical pulmonary carcinoidNational Cancer DatabasePredictors of survivalOptimal surgical managementAtypical carcinoid tumorCell lung cancerProportional hazards regressionKaplan-Meier survivalLong-term survivalNodal upstagingSurgical resectionMultivariable analysisSurgical managementHazards regressionLarge tumorsInterplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival
Shan N, Li N, Dai Q, Hou L, Yan X, Amei A, Lu L, Wang Z. Interplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival. Cancers 2020, 12: 2230. PMID: 32785169, PMCID: PMC7466003, DOI: 10.3390/cancers12082230.Peer-Reviewed Original ResearchT cell activationBreast cancer patient survivalCancer patient survivalOverall survivalCell activationBreast cancerExpression of tRFsImproved survivalPatient survivalMultivariate Cox regression modelBreast cancer patientsCox regression modelKaplan-Meier survivalSpearman correlation analysisEffector CD8Cytotoxic functionCancer patientsExhaustion groupsTherapeutic targetCancer progressionCancerSurvivalGene co-expression network analysisActivation groupTRNA-derived fragmentsMaspin as a Prognostic Marker for Early Stage Colorectal Cancer With Microsatellite Instability
Tanaka A, Wang J, Shia J, Zhou Y, Ogawa M, Hendrickson R, Klimstra D, Roehrl M. Maspin as a Prognostic Marker for Early Stage Colorectal Cancer With Microsatellite Instability. Frontiers In Oncology 2020, 10: 945. PMID: 32587829, PMCID: PMC7297950, DOI: 10.3389/fonc.2020.00945.Peer-Reviewed Original ResearchColorectal cancerStage cancer patientsPrognostic markerCancer patientsMicrosatellite instabilityStage cancerDisease-free survivalMicrosatellite stabilityKaplan-Meier survivalMaspin expression levelsImproving therapeutic managementEarly stage cancer patientsStage colorectal cancerEarly stage colorectal cancerLate stage cancer patientsLate stage cancerEarly stage cancerPrognostic significanceMaspin expression
2018
SURG-06. LASER ABLATION FOR BRAIN METASTASES: SAFETY AND PRELIMINARY OUTCOMES FROM THE LASER ABLATION OF ABNORMAL NEUROLOGICAL TISSUE USING ROBOTIC NEUROBLATE SYSTEM (LAANTERN) REGISTRY
Kamath A, Tatter S, Fecci P, Chen C, Chiang V, Rao G, Mohammadi A, Judy K, Field M, Neimat J, Leuthardt E, Kim A. SURG-06. LASER ABLATION FOR BRAIN METASTASES: SAFETY AND PRELIMINARY OUTCOMES FROM THE LASER ABLATION OF ABNORMAL NEUROLOGICAL TISSUE USING ROBOTIC NEUROBLATE SYSTEM (LAANTERN) REGISTRY. Neuro-Oncology 2018, 20: vi251-vi251. PMCID: PMC6216263, DOI: 10.1093/neuonc/noy148.1042.Peer-Reviewed Original ResearchLaser interstitial thermal therapyBrain metastasesProcedural dataDeath rateAblation coverageMedian overall survivalAcceptable safety profileSingle-center experienceDay of procedureKaplan-Meier survivalNeurological tissuesAverage lesion volumeLocation of lesionsPreliminary outcomesInterstitial thermal therapyAdverse eventsOngoing registryOverall survivalCenter experienceSafety profileMean ageInvasive optionTarget lesionsProcedural efficacyLesion volume
2017
Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity
Mohan S, Pai S, Bhattacharyya N. Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity. The Laryngoscope 2017, 127: 1334-1338. PMID: 28150306, PMCID: PMC7388729, DOI: 10.1002/lary.26443.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Squamous CellCarcinoma, VerrucousCross-Sectional StudiesDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedMouthMouth NeoplasmsNeoplasm Recurrence, LocalRadiotherapy, AdjuvantSEER ProgramSquamous Cell Carcinoma of Head and NeckTreatment OutcomeConceptsAdjuvant radiation therapyDisease-specific survivalSquamous cell carcinomaVerrucous carcinomaRadiation therapyOverall survivalOral cavityVC patientsWorse OSCarcinoma patientsImproved overall survivalEnd Results (SEER) databaseKaplan-Meier survivalAdjuvant radiotherapySCC patientsLocal recurrenceResults databaseT stagePositive marginsSCC casesCell carcinomaPatientsSurgeryCarcinomaDifferent biology
2015
Anal cancer outcomes in patients treated with intensity modulated versus 3-dimensional chemoradiotherapy.
Cooper B, Grew D, Bitterman D, Sanfilippo N, Du K. Anal cancer outcomes in patients treated with intensity modulated versus 3-dimensional chemoradiotherapy. Journal Of Clinical Oncology 2015, 33: 662-662. DOI: 10.1200/jco.2015.33.3_suppl.662.Peer-Reviewed Original ResearchDistant metastasis-free survivalLocal recurrence-free survivalColostomy-free survivalOverall survivalTreatment interruptionLymph nodesTreatment breaksSkin toxicityRadiation therapyThree-year overall survivalAnal cancer outcomesGrowth factor supportRecurrence-free survivalMetastasis-free survivalSquamous cell carcinomaKaplan-Meier survivalConformal radiation therapyRadiation techniquesLog-rank statisticsChi-square testAcute gastrointestinalAcute GIDefinitive chemoradiotherapyIMRT cohortRTOG 0529
2014
Bland embolization versus chemoembolization of hepatocellular carcinoma before transplantation
Kluger MD, Halazun KJ, Barroso RT, Fox AN, Olsen SK, Madoff DC, Siegel AB, Weintraub JL, Sussman J, Brown RS, Cherqui D, Emond JC. Bland embolization versus chemoembolization of hepatocellular carcinoma before transplantation. Liver Transplantation 2014, 20: 536-543. PMID: 24493271, PMCID: PMC4095977, DOI: 10.1002/lt.23846.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, HepatocellularCase-Control StudiesChemoembolization, TherapeuticDisease-Free SurvivalEnd Stage Liver DiseaseFemaleHumansKaplan-Meier EstimateLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTime FactorsTreatment OutcomeConceptsWait-list dropoutTAE patientsTACE patientsTransarterial embolizationTransarterial chemoembolizationHCC patientsEnd-stage liver disease (MELD) scoreSurvival rateRecurrence-free survival ratesMethods of embolizationRadiographic tumor sizeLiver Disease scoreOverall survival rateRecurrence-free survivalKaplan-Meier survivalBland transarterial embolizationCase-control studySignificant demographic differencesExplant tumorsPrimary endpointTreat basisTumor sizeHepatocellular carcinomaDisease scorePatientsDevelopment of pulmonary hypertension in a high-risk population with systemic sclerosis in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) cohort study
Hsu VM, Chung L, Hummers LK, Wigley F, Simms R, Bolster M, Silver R, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Alkassab F, Steen VD. Development of pulmonary hypertension in a high-risk population with systemic sclerosis in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) cohort study. Seminars In Arthritis And Rheumatism 2014, 44: 55-62. PMID: 24709277, DOI: 10.1016/j.semarthrit.2014.03.002.Peer-Reviewed Original ResearchConceptsSystolic pulmonary arterial pressureRight heart catheterizationExercise-induced hypoxiaPulmonary hypertensionPulmonary arterial hypertensionPulmonary function testingSystemic sclerosisCohort studyDisease durationHigher systolic pulmonary arterial pressureProspective longitudinal cohort studyFVC/DLcoNew pulmonary hypertensionPulmonary Hypertension AssessmentDiffusion lung capacityPulmonary arterial pressureOngoing prospective studyKaplan-Meier survivalHigh-risk populationKaplan-Meier estimatesLongitudinal cohort studyHigh-risk factorsRecognition of OutcomesPFT criteriaPH patientsExperience with Thoracoscopic Pneumonectomies at a Single Institution
Kim AW, Fonseca AL, Boffa DJ, Detterbeck FC. Experience with Thoracoscopic Pneumonectomies at a Single Institution. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 82-86. PMID: 24755537, DOI: 10.1097/imi.0000000000000058.Peer-Reviewed Original ResearchConceptsVideo-assisted thoracoscopic pneumonectomyThoracoscopic pneumonectomyLung cancerExperienced thoracoscopic surgeonsMetastatic esophageal cancerPrimary lung cancerSingle institution experienceDistant disease recurrenceMultidisciplinary tumor boardKaplan-Meier survivalCompletion pneumonectomyLesser resectionsR0 resectionClinical stagingDisease recurrencePathologic stagingPatient selectionSleeve resectionAtrial fibrillationBronchopleural fistulaClinical parametersComplication profileMedian lengthPreoperative selectionSingle institutionExperience with Thoracoscopic Pneumonectomies at a Single Institution
Kim A, Fonseca A, Boffa D, Detterbeck F. Experience with Thoracoscopic Pneumonectomies at a Single Institution. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 82-86. DOI: 10.1177/155698451400900202.Peer-Reviewed Original ResearchVideo-assisted thoracoscopic pneumonectomyThoracoscopic pneumonectomyLung cancerExperienced thoracoscopic surgeonsMetastatic esophageal cancerPrimary lung cancerSingle institution experienceDistant disease recurrenceMultidisciplinary tumor boardKaplan-Meier survivalCompletion pneumonectomyLesser resectionsR0 resectionClinical stagingDisease recurrencePathologic stagingPatient selectionSleeve resectionAtrial fibrillationBronchopleural fistulaClinical parametersComplication profileMedian lengthPreoperative selectionSingle institution
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