2024
Comparison of EEG Signal Characteristics of Subdural and Depth Electrodes.
Alkawadri C, Yan Q, Kocuglu Kinal A, Spencer D, Alkawadri R. Comparison of EEG Signal Characteristics of Subdural and Depth Electrodes. Journal Of Clinical Neurophysiology 2024 PMID: 39787440, DOI: 10.1097/wnp.0000000000001139.Peer-Reviewed Original ResearchStereo-EEGHigh gamma bandSurgical epilepsy centersDrug-resistant epilepsyIntracranial EEG evaluationElectrode contact pairsImpact of electrode sizeElectrode sizeEffects of electrode sizeEEG evaluationCompare signal characteristicsHigh-frequency signalsEpilepsy centersSignal-to-noise ratioInterquartile rangeMedian correlation coefficientIntracranial EEGPower spectral densitySubdural electrodesPower ratioElectrode designFast-Fourier transformHigh gammaMedian distanceContact pairs
2022
Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localization
2017
Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity
Quraishi IH, Benjamin CF, Spencer DD, Blumenfeld H, Alkawadri R. Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity. Epilepsy & Behavior Reports 2017, 8: 117-122. PMID: 29204347, PMCID: PMC5707211, DOI: 10.1016/j.ebcr.2017.09.006.Peer-Reviewed Case Reports and Technical NotesElectrical cortical stimulationLoss of consciousnessCortical stimulationFrontal convexityFocal cortical stimulationIntracranial EEG evaluationBilateral electrical stimulationImpairment of consciousnessCessation of stimulationLateral frontal lobeFronto-parietal areasIntractable epilepsyIctal dischargesRarity of reportsElectrophysiological findingsFocal epilepsyEpileptic focusEEG evaluationIntracranial EEG recordingsCase of impairmentCortical connectivityElectrical stimulationEpileptic seizuresFrontal lobeSubcortical structures
2013
Intracranial EEG evaluation of relationship within a resting state network
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.Peer-Reviewed Original ResearchConceptsDefault mode networkIntracranial EEG evaluationMode networkLocalization-related epilepsyCross-approximate entropyNeuronal involvementHemodynamic measurementsIntracranial EEG recordingsEEG evaluationBackground activityGamma powerFMRI studyIntracranial EEGBrain activityPatientsEEG recordingsLow levelsT2EpilepsyMagnitude squared coherenceT1
2008
Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients
Cavus I, Pan JW, Hetherington HP, Abi‐Saab W, Zaveri HP, Vives KP, Krystal JH, Spencer SS, Spencer DD. Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients. Epilepsia 2008, 49: 1358-1366. PMID: 18410365, DOI: 10.1111/j.1528-1167.2008.01603.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHippocampal volumeClinical factorsHippocampal atrophyEpileptogenic hippocampusGABA levelsNeurochemical levelsElevated extracellular glutamate levelsContralateral hippocampal volumeIntracranial EEG evaluationMedication-resistant epilepsyRefractory TLE patientsHigh seizure frequencyRelevant clinical factorsSmaller hippocampal volumesExtracellular glutamate levelsFebrile seizure historyTreatment of epilepsySeizure frequencyLobe epilepsySeizure historyTLE patientsAtrophic hippocampusGlutamate levelsExtracellular glutamate
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