2017
Response of Npt2a knockout mice to dietary calcium and phosphorus
Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C. Response of Npt2a knockout mice to dietary calcium and phosphorus. PLOS ONE 2017, 12: e0176232. PMID: 28448530, PMCID: PMC5407772, DOI: 10.1371/journal.pone.0176232.Peer-Reviewed Original ResearchConceptsCompared to WT miceWT miceDietary calciumDietary phosphateCalcium x phosphorus productUrine phosphate levelsUrinary calcium excretionUrine anion gapDevelopment of novel therapiesWild-typeRenal stone diseaseWild-type miceNpt2a-knockout (KO) miceCalcium excretionFGF23 levelsNovel therapiesPreventing nephrolithiasisPlasma phosphateStone diseaseAnion gapAddition of calciumKnockout micePhosphorus productCalcium phosphate depositionHuman carriers
2015
A rare case of fatal stroke after ethylene glycol toxicity
Garg D, Lim T, Irani M. A rare case of fatal stroke after ethylene glycol toxicity. BMJ Case Reports 2015, 2015: bcr2014208855. PMID: 25809433, PMCID: PMC4386312, DOI: 10.1136/bcr-2014-208855.Peer-Reviewed Original ResearchConceptsEthylene glycol toxicityGlycol toxicityAcute left-sided weaknessFurther blood testsLeft-sided weaknessSerum osmolal gapNeurological improvementFatal strokeAcute infarctionGeneralised oedemaBlood testsEmergency departmentOsmolal gapAnion gapBrain MRIRare casePatientsVisual fieldAcetone odorMOsm/StrokeToxicityTimely fashionDaysFomepizole
2013
Chapter 59 Clinical Syndromes of Metabolic Acidosis
Krapf R, Seldin D, Alpern R. Chapter 59 Clinical Syndromes of Metabolic Acidosis. 2013, 2049-2111. DOI: 10.1016/b978-0-12-381462-3.00059-8.Peer-Reviewed Original ResearchMetabolic acidosisDivalent ion metabolismMaladaptive renal responseUrine anion gapAcute metabolic acidosisNegative nitrogen balanceAcid-base disturbancesBlood buffer capacitySecondary hypocapniaClinical sequelaeRenal responseChronic settingClinical syndromeVentilatory responseBone metabolismBone massAnion gapPrimary decreaseSevere formDiagnostic criteriaBone qualitySecondary decreaseAcidosisElectrolyte changesClinical setting
1996
Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole.
Alappan R, Perazella M, Buller G. Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. Annals Of Internal Medicine 1996, 124: 316-20. PMID: 8554227, DOI: 10.7326/0003-4819-124-3-199602010-00006.Peer-Reviewed Original ResearchConceptsSerum potassium concentrationSerum creatinine levelsMumol/LBlood urea nitrogen levelsPeak potassium concentrationTrimethoprim-sulfamethoxazole therapyCreatinine levelsUrea nitrogen levelsTrimethoprim-sulfamethoxazoleTreatment groupsPotassium concentrationControl groupCommunity-based teaching hospitalDevelopment of hyperkalemiaDays of therapyProspective chart reviewConcurrent renal insufficiencyRenal insufficiencyChart reviewSevere hyperkalemiaHospitalized patientsSerum sodiumTeaching hospitalAnion gapPatients
1987
Predicting emergency readmissions for patients discharged from the medical service of a teaching hospital
Phillips R, Safran C, Cleary P, Delbanco T. Predicting emergency readmissions for patients discharged from the medical service of a teaching hospital. Journal Of General Internal Medicine 1987, 2: 400-405. PMID: 3694300, DOI: 10.1007/bf02596366.Peer-Reviewed Original ResearchConceptsEmergency readmissionRenal diseaseTeaching hospitalAcute care teaching hospitalGreater hospital chargesDays of dischargeRisk factor profileElevated anion gapAvailable clinical dataMedical servicesReadmitted patientsLonger hospitalizationPatient demographicsPrior admissionClinical factorsHeart failureDischarge diagnosisHospital chargesRelative riskClinical dataAnion gapReadmissionReduced riskPatientsFactor profile
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