2023
Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation
Freitas-Andrade M, Comin C, Van Dyken P, Ouellette J, Raman-Nair J, Blakeley N, Liu Q, Leclerc S, Pan Y, Liu Z, Carrier M, Thakur K, Savard A, Rurak G, Tremblay M, Salmaso N, da F. Costa L, Coppola G, Lacoste B. Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation. Nature Communications 2023, 14: 4965. PMID: 37587100, PMCID: PMC10432480, DOI: 10.1038/s41467-023-40682-3.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Blood-brain barrierGroup box 1Brain blood vesselsMouse cortical astrocytesPostnatal brain developmentAstroglial factorsNeurovascular couplingAstrocyte morphogenesisCortical astrocytesPostnatal weekAdult miceBox 1Aquaporin-4Endothelial ultrastructureAstrocyte morphologyNeuronal functionAstrocytesBrain developmentTranscriptional changesHMGB1Blood vesselsBirthAlters distributionImportant playersThree-dimensional imaging of vascular development in the mouse epididymis.
Damon-Soubeyrand C, Bongiovanni A, Chorfa A, Goubely C, Pirot N, Pardanaud L, Piboin-Fragner L, Vachias C, Bravard S, Guiton R, Thomas J, Saez F, Kocer A, Tardivel M, Drevet J, Henry-Berger J. Three-dimensional imaging of vascular development in the mouse epididymis. ELife 2023, 12 PMID: 37310207, PMCID: PMC10264076, DOI: 10.7554/elife.82748.Peer-Reviewed Original ResearchConceptsProtection of spermatozoaComplex immune functionsAccessory tubulesVascular developmentMouse epididymisCellular levelSecretory roleImportant playersMale fertilityMale reproductive systemOrgan clearingMature adult miceReproductive systemTransgenic mouse modelFunctional maturationPeripheral toleranceBlood markersImmune responseLymphatic networkImmune functionKey determinantMouse modelSurvival of spermatozoaAdult miceImmune system
2019
The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress
Ho R, Tahboub R, Amraei R, Meyer R, Varongchayakul N, Grinstaff M, Rahimi N. The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress. Journal Of Biological Chemistry 2019, 294: 13671-13680. PMID: 31341021, PMCID: PMC6746441, DOI: 10.1074/jbc.ra119.008548.Peer-Reviewed Original ResearchConceptsIGPR-1Cell adhesion molecule IGPR-1Proline-rich receptor-1AKT Ser/ThrActin stress fiber assemblySer/ThrCell-cell junctionsStress fiber assemblyCell-cell contactEndothelial cellsActin fiber assemblyEndothelial cell remodelingFiber assemblyCell mechanosensingBlood flow-induced shear stressCell remodelingCellular responsesMechanical signalsVascular endothelial cellsImportant playersFlow-induced shear stressPhosphorylationCellsReceptor 1Cell borders
2017
Stomach and Bone
Kitay AM, Geibel JP. Stomach and Bone. Advances In Experimental Medicine And Biology 2017, 1033: 97-131. PMID: 29101653, DOI: 10.1007/978-3-319-66653-2_6.Peer-Reviewed Original ResearchConceptsBone metabolismGastric acid secretionCalcium-sensing receptorVitamin DParathyroid glandsAcid secretionGastrointestinal organsTherapeutic implicationsEndocrine modulatorsCalcium homeostasisDiseaseStomachOrgansMetabolismImportant playersIntermediary organDiverse tissuesDysfunctionCaSRPTHCalcitoninKidneySecretionIntestineReceptorsGrowth of the Kidney–Cancer Connection
Perazella M. Growth of the Kidney–Cancer Connection. Journal Of Onco-Nephrology 2017, 1: 71-73. DOI: 10.5301/jo-n.5000015.Peer-Reviewed Original Research
2016
Chapter 11 Prognostic Epigenetics
Sharma A, Abdelfatah E, Al Eissa M, Ahuja N. Chapter 11 Prognostic Epigenetics. 2016, 177-195. DOI: 10.1016/b978-0-12-803239-8.00011-9.Peer-Reviewed Original Research
2013
Mitogen-Activated Protein Kinase Phosphatases in Metabolism
Lawan A, Bennett A. Mitogen-Activated Protein Kinase Phosphatases in Metabolism. 2013, 221-238. DOI: 10.1007/978-1-4614-7855-3_12.Peer-Reviewed Original ResearchMitogen-activated protein kinaseMetabolic homeostasisProtein kinaseTissue-specific mannerFamily of enzymesDirect dephosphorylationPathophysiological signalingMAPK activityMAPK inactivationMetabolic signalingImportant playersMKPHomeostasisKinaseCritical roleSignalingBody of evidenceMetabolismDephosphorylationComplex networksComparable levelsEnzymeMitogenPathwayRegulation
2003
Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector
Horvath TL, Diano S, Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochemical Pharmacology 2003, 65: 1917-1921. PMID: 12787871, DOI: 10.1016/s0006-2952(03)00143-6.Peer-Reviewed Original ResearchConceptsMitochondrial membrane potentialInner membraneRole of UCP2Normal neuronal functionDiverse tissuesUnknown functionProtein 2Functional significanceImportant playersCentral nervous systemNeuronal functionProteinMembrane potentialNervous systemUCP2Disease statesUCPBrown adipose tissueNew avenuesMitochondriaTissueAdipose tissueUCP1Better understandingUncoupler
2002
Notch Signaling in the Brain: More than Just a Developmental Story
Šestan N, Rakic P. Notch Signaling in the Brain: More than Just a Developmental Story. Research And Perspectives In Alzheimer's Disease 2002, 19-40. DOI: 10.1007/978-3-642-55996-9_2.Peer-Reviewed Original ResearchNotch signalingNeural developmentCell-cell interaction mechanismCell fate acquisitionCell fate decisionsEarly neural developmentDifferent signaling mechanismsVariety of speciesFate acquisitionNotch signalsCellular phenotypesNotch pathwayMolecular mechanismsSignaling mechanismApoptotic cuesNeuronal differentiationMolecular processesNervous systemAlzheimer's diseaseAdult-onset neurological disordersNeural cellsImportant playersSignalingNeurodegenerative disordersLife span
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