2019
PS1313 FEASIBILITY AND PRELIMINARY RESULTS OF A PROSPECTIVE EVALUATION OF RESIDUAL DISEASE IN DIFFUSE LARGE B‐CELL LYMPHOMAS USING DEEP SEQUENCING OF CELL FREE DNA AND DNA FROM FORMALIN FIXED BIOPSIES
Carniti C, Biancon G, Banfi S, Vella C, Magni M, Pennisi M, Anna D, Guidetti A, Corradini P. PS1313 FEASIBILITY AND PRELIMINARY RESULTS OF A PROSPECTIVE EVALUATION OF RESIDUAL DISEASE IN DIFFUSE LARGE B‐CELL LYMPHOMAS USING DEEP SEQUENCING OF CELL FREE DNA AND DNA FROM FORMALIN FIXED BIOPSIES. HemaSphere 2019, 3: 599-600. DOI: 10.1097/01.hs9.0000563532.69483.ec.Peer-Reviewed Original ResearchCell-free DNADLBCL patientsIgH gene rearrangementTumor burdenResidual diseaseIgH rearrangementsGene rearrangementsDiffuse large B-cell lymphoma patientsLarge B-cell lymphoma patientsB-cell lymphoma patientsDiffuse large B-cell lymphomaLarge B-cell lymphomaPossible disease progressionPossible residual diseaseR-CHOP therapyBaseline plasma samplesLymph node biopsyDisease monitoringImmunoglobulin heavy chain gene rearrangementMultiple myeloma patientsNon-invasive disease monitoringCell lymphoma patientsNumber of patientsFFPE samplesPET-CT scanPrognostic markers for immunodeficiency-associated primary central nervous system lymphoma
Kaulen LD, Galluzzo D, Hui P, Barbiero F, Karschnia P, Huttner A, Fulbright R, Baehring JM. Prognostic markers for immunodeficiency-associated primary central nervous system lymphoma. Journal Of Neuro-Oncology 2019, 144: 107-115. PMID: 31190317, DOI: 10.1007/s11060-019-03208-w.Peer-Reviewed Original ResearchConceptsPrimary central nervous system lymphomaDiffusion-weighted imaging patternsMagnetic resonance imagingCentral nervous system lymphomaNervous system lymphomaSystem lymphomaPeripheral enhancementDWI patternsPCNSL casesImaging featuresPrognostic markerHuman immunodeficiency virus (HIV) infectionKaplan-Meier survival analysisDiffuse large B-cell lymphomaYale-New Haven HospitalLarge B-cell lymphomaMedian overall survivalImmunodeficiency virus infectionPredictors of survivalSolid organ transplantationImmunoglobulin heavy chain gene rearrangementPeripheral contrast enhancementLog-rank testMajor risk factorHeavy chain gene rearrangement
1997
Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement
Ritter J, Wick M, Adesokan P, Fitzgibbon J, Zhu X, Humphrey P. Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement. American Journal Of Clinical Pathology 1997, 108: 60-68. PMID: 9208979, DOI: 10.1093/ajcp/108.1.60.Peer-Reviewed Original ResearchConceptsCutaneous lymphoid infiltratesPolymerase chain reactionLymphoid infiltratesMonoclonal bandImmunoglobulin heavy chain geneFalse-positive resultsT cellsCell lymphomaB cellsValue of PCRLarge cell casesSparse perivascular infiltrateImmunoglobulin heavy chain gene rearrangementMixed cell lymphomaLarge cell lymphomaB-cell immunophenotypeHeavy chain gene rearrangementHeavy chain geneAssessment of clonalityChain gene rearrangementPerivascular infiltratesClinical featuresPolymerase chain reaction analysisClinical findingsMixed lesions
1996
Lymphomatoid Granulomatosis of the Skin and Lung: An Angiocentric T-Cell-Rich B-Cell Lymphoproliferative Disorder
McNiff J, Cooper D, Howe G, Crotty P, Tallini G, Crouch J, Eisen R. Lymphomatoid Granulomatosis of the Skin and Lung: An Angiocentric T-Cell-Rich B-Cell Lymphoproliferative Disorder. JAMA Dermatology 1996, 132: 1464-1470. DOI: 10.1001/archderm.1996.03890360054010.Peer-Reviewed Original ResearchLymphomatoid granulomatosisEpstein-Barr virusEBV RNAB cellsLymphoproliferative disordersPolymerase chain reactionT-cell lymphoproliferative disorderEpstein-Barr virus RNAB-cell lymphoproliferative disordersClonality of lymphocytesT-cell infiltratesAcademic referral centerImmunoglobulin heavy chain gene rearrangementT-cell markersGene rearrangementsChain reactionHeavy chain gene rearrangementClonal immunoglobulin heavy chain gene rearrangementT-cell receptor βT-cell receptor genesClonal gene rearrangementsChain gene rearrangementAngiocentric infiltratesImmunoglobulin heavy chain geneReferral centerLymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.
McNiff J, Cooper D, Howe G, Crotty P, Tallini G, Crouch J, Eisen R. Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. JAMA Dermatology 1996, 132: 1464-70. PMID: 8961876, DOI: 10.1001/archderm.132.12.1464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedB-LymphocytesCell DivisionClone CellsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinHerpesvirus 4, HumanHumansImmunoglobulin Heavy ChainsImmunophenotypingIn Situ HybridizationLung DiseasesLymphomatoid GranulomatosisMaleMiddle AgedPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRetrospective StudiesRNA, ViralSkin DiseasesT-LymphocytesConceptsLymphomatoid granulomatosisEpstein-Barr virusEBV RNAB cellsLymphoproliferative disordersPolymerase chain reactionT-cell lymphoproliferative disorderEpstein-Barr virus RNAB-cell lymphoproliferative disordersClonality of lymphocytesT-cell infiltratesAcademic referral centerImmunoglobulin heavy chain gene rearrangementT-cell markersGene rearrangementsT-cell receptor betaChain reactionHeavy chain gene rearrangementClonal immunoglobulin heavy chain gene rearrangementT-cell receptor genesClonal gene rearrangementsChain gene rearrangementAngiocentric infiltratesImmunoglobulin heavy chain geneReferral centerDiffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry.
Robert M, Kuo F, Longtine J, Sklar J, Schrock T, Weidner N. Diffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry. The American Journal Of Surgical Pathology 1996, 20: 1024-31. PMID: 8712289, DOI: 10.1097/00000478-199608000-00011.Peer-Reviewed Original ResearchConceptsUlcerative colitisColonic lymphomaMantle cell lymphomaMucosal changesCell lymphomaInflammatory mucosal changesPrimary colonic lymphomaSevere ulcerative colitisImmunoglobulin heavy chain gene rearrangementHigh-grade morphologyHeavy chain gene rearrangementMonoclonal lymphoid populationLate complicationsMucosal injuryUnderlying diseasePrimary lymphomaFurther workupInitial diagnosisResection specimenPolymerase chain reactionSuperficial biopsiesLymphoid proliferationsColitisLymphoid populationsLymphoma
1994
Multiple myeloma after cardiac transplantation: An unusual form of posttransplant lymphoproliferative disorder
Chucrallah A, Crow M, Rice L, Rajagopalan S, Hudnall S. Multiple myeloma after cardiac transplantation: An unusual form of posttransplant lymphoproliferative disorder. Human Pathology 1994, 25: 541-545. PMID: 8200651, DOI: 10.1016/0046-8177(94)90129-5.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, ViralBase SequenceDNA-Binding ProteinsEpstein-Barr Virus Nuclear AntigensGene RearrangementGenes, ImmunoglobulinHeart TransplantationHerpesvirus 4, HumanHumansIn Situ HybridizationLymphoproliferative DisordersMaleMiddle AgedMolecular Sequence DataMultiple MyelomaPolymerase Chain ReactionRNA, ViralConceptsPosttransplant lymphoproliferative disorderPolymerase chain reactionCardiac transplantationLymphoproliferative disordersMonoclonal immunoglobulin heavy chain gene rearrangementEBV-negative casesPast EBV infectionCardiac transplant recipientsImmature plasma cellsImmunoglobulin heavy chain gene rearrangementHeavy chain gene rearrangementChain gene rearrangementCyclosporin withdrawalEBV infectionTransplant recipientsEBER-1Monomorphous populationMultiple myelomaEBV genomePlasma cellsSkull lesionsMyelomaSerum analysisGene rearrangementsChain reaction
1987
B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus
Garcia C, Brown N, Schreck R, Stiehm E, Hudnall S. B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus. Cancer 1987, 60: 2941-2947. PMID: 2824020, DOI: 10.1002/1097-0142(19871215)60:12<2941::aid-cncr2820601216>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus nuclear antigenB-cell lymphomaB-cell lymphoproliferative disordersEBV DNASevere combined immunodeficiencyLymphoproliferative disordersMalignant B-cell lymphomaEBV DNA probePrevention of EBVImmunoglobulin heavy chain gene rearrangementB-cell lymphoproliferationEpstein-Barr virusClonal B-cell lymphomaGene rearrangementsHeavy chain gene rearrangementClonal Ig gene rearrangementsChain gene rearrangementAntiviral chemoprophylaxisTransplant patientsSuch prophylaxisImmunodeficient patientsTumor cell DNAAnticomplement immunofluorescenceSitu cytohybridizationPatients
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