2025
POS1002 ALTERED GUT MICROBIOTA COMPOSITION IN AUTOIMMUNE DISEASE PATIENTS UNDERGOING CD19-CAR T-CELL THERAPY
Maeda Y, Wirtz S, Hagen M, Rothe T, Wirsching A, Grieshaber-Bouyer R, Gimaev I, Schmid E, Kriegel M, Müller F, Mackensen A, Schett G, Zaiss M. POS1002 ALTERED GUT MICROBIOTA COMPOSITION IN AUTOIMMUNE DISEASE PATIENTS UNDERGOING CD19-CAR T-CELL THERAPY. Annals Of The Rheumatic Diseases 2025, 84: 1114-1115. DOI: 10.1016/j.ard.2025.06.357.Peer-Reviewed Original ResearchCD19 CAR T-cell therapyCD19 CAR-T cellsT-cell therapySystemic lupus erythematosusIdiopathic inflammatory myopathiesFecal IgA levelsCD19-CART cellsSerum IgA levelsAutoimmune diseasesIgA levelsSystemic sclerosisGut microbiota compositionLupus erythematosusInfusion of CD19-CAR T cellsChimeric antigen receptor (CAR)-T cellsTransfection of T cellsSevere systemic lupus erythematosusStreptococcus speciesFecal IgA contentSecond-generation CARDrug-free remissionLong-term remissionPathogenesis of autoimmune diseasesMicrobiota compositionLoss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy
Prakash S, Steers N, Li Y, Sanchez-Rodriguez E, Verbitsky M, Robbins I, Simpson J, Pathak S, Raska M, Reily C, Ng A, Liang J, DeMaria N, Katiraei A, O'Stevens K, Fischman C, Shapiro S, Kodali S, McCutchan J, Park H, Eliby D, Delsante M, Allegri L, Fiaccadori E, Bodria M, Marasa M, Raveche E, Julian B, Uhlemann A, Kiryluk K, Zhang H, D'Agati V, Sanna-Cherchi S, Novak J, Gharavi A. Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy. Journal Of Clinical Investigation 2025, 135: e181164. PMID: 40153534, PMCID: PMC12077892, DOI: 10.1172/jci181164.Peer-Reviewed Original ResearchConceptsO-glycosylationAberrant O-glycosylationIgA nephropathyMucosal immunityN-acetylgalactosaminyltransferaseElevated serum IgA levelsAdoptive-transfer experimentsB-cell homingSerum IgA levelsProtein O-glycosylationIgA-producing cellsGlomerular IgA depositionImmune-complex formationPathogenesis of IgANIgA1 hinge regionIgA1-producing cellsPeripheral bloodImpaired homingKidney injuryB cellsB lymphocytesIgA levelsLoF variantsIgA depositionGalNAc-T14
2022
Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice
Maskey A, Srivastava K, Soffer G, Dunkin D, Yuan Q, Li X. Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice. Journal Of Inflammation Research 2022, 15: 5527-5540. PMID: 36176352, PMCID: PMC9514888, DOI: 10.2147/jir.s372449.Peer-Reviewed Original ResearchAirborne allergensNormal controlsEosinophilic inflammationEosinophilic esophagitisTh2 cytokinesAntigen-specific IgE levelsCommon chronic inflammatory diseaseImportant pathologic roleMild eosinophilic inflammationSevere eosinophilic esophagitisSevere eosinophilic inflammationIL-4/ILBronchoalveolar lavage fluidChronic inflammatory diseaseMulti-organ inflammationGene-deficient miceChemokine gene expressionIgA levelsIgE levelsIgG levelsSerum totalSpecific IgETotal IgAWT miceLavage fluid
2020
Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes
Huang J, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Guo K, Wong FS, Zhou Z, Wen L. Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa590. PMID: 32860693, PMCID: PMC7549925, DOI: 10.1210/clinem/dgaa590.Peer-Reviewed Original ResearchConceptsIgA-bound bacteriaType 1 diabetesHealthy control individualsIgA immune responseControl individualsIgA immunityAutoantibody titersIgA concentrationsImmune responseType 1 diabetes patientsΒ-cell autoimmunityLonger disease durationSerum IgA concentrationNovel therapeutic targetEnzyme-linked immunosorbentDisease durationIgA levelsDiabetes patientsDiabetes displayGut homeostasisBlood samplesOral cavityTherapeutic targetDiabetesHost immunity
2019
Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry
Strober B, Greenberg J, Karki C, Mason M, Guo N, Hur P, Zhao Y, Herrera V, Lin F, Lebwohl M. Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry. BMJ Open 2019, 9: e027535. PMID: 31005939, PMCID: PMC6500315, DOI: 10.1136/bmjopen-2018-027535.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiological ProductsBody Surface AreaCross-Sectional StudiesEfficiencyFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisPainPain MeasurementPatient Reported Outcome MeasuresPsoriasisQuality of LifeRegistriesSeverity of Illness IndexSurveys and QuestionnairesTreatment OutcomeUnited StatesConceptsPatient-reported outcomesBody surface areaCorrona Psoriasis RegistrySevere psoriasisPsoriasis severityPsoriasis RegistryReal-world settingPatient-reported clinical symptomsWorse patient-reported outcomesGlobal assessmentMore severe psoriasisSystemic psoriasis treatmentsInvestigator's Global AssessmentHealth-related qualityMultivariable regression analysisMultivariable regression modelsCross-sectional analysisWPAI domainsWPAI scoresIGA scoreProspective registryAdult patientsIgA levelsDLQI scoreUS patients
2015
Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
Schupp J, Tchaptchet S, Lützen N, Engelhard P, Müller-Quernheim J, Freudenberg M, Prasse A. Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro. BMC Pulmonary Medicine 2015, 15: 75. PMID: 26204953, PMCID: PMC4513400, DOI: 10.1186/s12890-015-0070-7.Peer-Reviewed Original ResearchConceptsHeat-killed P. acnesSarcoid patientsP. acnesBAL cellsBAL fluidTotal IgGImmune responseHealthy volunteersPathogenesis of sarcoidosisSpecific antibodiesGM-CSF productionIgA titresIgA levelsLymph nodesInflammatory cytokinesGranuloma formationMore TNFSarcoidosisPatientsPropionibacterium acnesAcneGM-CSFElevated levelsAntibodiesIgG
2008
Antineutrophil Cytoplasmic Antibody in Korean Children with Henoch-Schönlein Purpura
Choi J, Shin J, Lee J, Kim H. Antineutrophil Cytoplasmic Antibody in Korean Children with Henoch-Schönlein Purpura. Childhood Kidney Diseases 2008, 12: 164-169. DOI: 10.3339/jkspn.2008.12.2.164.Peer-Reviewed Original ResearchP-ANCAC-ANCAElevation of serum IgA levelsElevated erythrocyte sedimentation rateAnti-streptolysin O titerHenoch Schonlein purpura(HSPAntineutrophil cytoplasmic antibodiesErythrocyte sedimentation rateHenoch-Schonlein purpuraSerum IgA levelsDiagnosis of HSPEULAR/PRES criteriaAbdominal painRenal involvementCytoplasmic antibodiesPalpable purpuraLaboratory findingsSerological markersFollow-upClinical significanceIgA levelsTarget antigenMedical recordsPatientsIndirect immunofluorescence
1993
Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis.
O'Neil C, Labrada M, Saravia N. Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis. American Journal Of Tropical Medicine And Hygiene 1993, 49: 181-8. PMID: 8357080, DOI: 10.4269/ajtmh.1993.49.181.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, ProtozoanAntibody SpecificityAntigens, ProtozoanChildChild, PreschoolCross ReactionsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin AImmunoglobulin EInfantLeishmania braziliensisLeishmaniasis, CutaneousLeishmaniasis, MucocutaneousMaleRadioallergosorbent TestRetrospective StudiesConceptsAmerican tegumentary leishmaniasisIgA antibodiesEnzyme-linked immunosorbent assayTegumentary leishmaniasisRadioallergosorbent testRAST valuesHuman tegumentary leishmaniasisDuration of diseaseIgA levelsMucocutaneous diseaseBiopsy specimenBiopsy specimensCutaneous diseaseSevere formPatientsHeterologous antigensDisease evolutionIgEImmunosorbent assayElevated levelsLeishmaniasisDiseaseInhibition testingAntibodiesSeparate groups
1992
Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users.
Chaisson R, Taylor E, Margolick J, Muñoz A, Solomon L, Cohn S, Nelson K, Vlahov D. Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 456. PMID: 1348535, DOI: 10.1097/00126334-199205000-00004.Peer-Reviewed Original ResearchConceptsCD4 cell countSerum immune markersDrug use patternsCell countCD4 countHIV statusImmune markersImmune activationDrug usersHuman immunodeficiency virus (HIV) infectionHIV-seropositive individualsImmunodeficiency virus infectionSerum IgA levelsIntravenous drug usersAssociation of raceIgA levelsNeopterin levelsSerum markersVirus infectionLarge cohortBacterial infectionsHIVHepatitisInfectionMarkers
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