2025
A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability
Lim B, Xu J, Wierzbicki I, Gonzalez C, Chen Z, Gonzalez D, Gao X, Goodman A. A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability. Cell Host & Microbe 2025, 33: 200-217.e24. PMID: 39909037, PMCID: PMC11931560, DOI: 10.1016/j.chom.2025.01.008.Peer-Reviewed Original ResearchConceptsHuman gut microbesChaperone complexGut microbesCommunity dynamicsHuman gut bacteriumProtein folding abilityProtein folding capacityHuman gut microbiomeMicrobial community dynamicsGut metagenomesNeighboring bacteriaExpression strainGut bacteriumMammalian gutFitness advantageGut microbiomeAllelic variationGenetic characterizationPathogen-induced inflammationSubstrate aggregationAntagonistic interactionsMicrobesRecipient cellsGutNeighboring cells
2024
OP0047 FASTING MODULATES THE HUMAN GUT MICROBIOME AND REDUCES AN IL-17+/IFNG+ T CELL-INDUCING GUT PATHOBIONT IN PATIENTS WITH RHEUMATOID ARTHRITIS
Pereira M, Stuhlträger K, Effelsberg N, Khokhar A, Redanz S, Ebid H, Hansen B, Laczny C, Löschberger U, Bletz S, Schneider J, Wilmes P, Kessler C, Michalsen A, Mellmann A, Kriegel M. OP0047 FASTING MODULATES THE HUMAN GUT MICROBIOME AND REDUCES AN IL-17+/IFNG+ T CELL-INDUCING GUT PATHOBIONT IN PATIENTS WITH RHEUMATOID ARTHRITIS. Annals Of The Rheumatic Diseases 2024, 83: 51-52. DOI: 10.1136/annrheumdis-2024-eular.3302.Peer-Reviewed Original Research
2023
Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide
Diebold P, Rhee M, Shi Q, Trung N, Umrani F, Ahmed S, Kulkarni V, Deshpande P, Alexander M, Thi Hoa N, Christakis N, Iqbal N, Ali S, Mathad J, Brito I. Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide. Nature Communications 2023, 14: 7366. PMID: 37963868, PMCID: PMC10645880, DOI: 10.1038/s41467-023-42998-6.Peer-Reviewed Original ResearchConceptsResistance genesSet of genesGut microbiome samplesHuman gut microbiomeGut microbiotaTaxonomic rangeEnvironmental metagenomesDifferent phylaGut microbiomeTaxonomic associationsIsolate genomesAntibiotic resistance genesAR geneRelevant antibiotic resistance genesGenesDiverse membersHuman metagenomesMicrobiome samplesPCR approachGene profilesAntimicrobial resistance genesCommensal gut microbiotaMobilizable plasmidsMetagenomesImportant pathogenThe effect of single dose albendazole (400 mg) treatment on the human gut microbiome of hookworm-infected Ghanaian individuals
Appiah-Twum F, Akorli J, Okyere L, Sagoe K, Osabutey D, Cappello M, Wilson M. The effect of single dose albendazole (400 mg) treatment on the human gut microbiome of hookworm-infected Ghanaian individuals. Scientific Reports 2023, 13: 11302. PMID: 37438457, PMCID: PMC10338455, DOI: 10.1038/s41598-023-38376-3.Peer-Reviewed Original ResearchConceptsHookworm infectionAlbendazole treatmentMicrobiota compositionStool samplesGut microbiomeGut microbiome dysbiosisInfection cure rateKintampo North MunicipalityPre-treatment statePotential microbial biomarkersAdjunct treatmentAnthelminthic therapySingle doseCure rateMicrobiome dysbiosisTreatment outcomesGut homeostasisPharmacological responseProbiotic supplementationGut microbiotaUninfected individualsCommensal bacteriaInfected individualsTherapy outcomeHuman gut microbiome
2016
Human symbionts inject and neutralize antibacterial toxins to persist in the gut
Wexler AG, Bao Y, Whitney JC, Bobay LM, Xavier JB, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD, Goodman AL. Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 3639-3644. PMID: 26957597, PMCID: PMC4822603, DOI: 10.1073/pnas.1525637113.Peer-Reviewed Original ResearchConceptsHuman gut symbiontGut symbiontsMicrobial communitiesProminent Human Gut SymbiontHundreds of speciesHuman gut commensalGut microbial communityContact-dependent killingHuman gut microbiomeAntibacterial toxinsInterbacterial interactionsInteraction assaysCommunity compositionInterbacterial antagonismEffector lociImmunity genesMajor phylaSecretome studiesHuman symbiontsSymbiontsMicrobiome manipulationGut microbesGut commensalsMultiple mouse modelsGut microbiome
2013
The Human Gut Microbiome: A Review of the Effect of Obesity and Surgically Induced Weight Loss
Sweeney TE, Morton JM. The Human Gut Microbiome: A Review of the Effect of Obesity and Surgically Induced Weight Loss. JAMA Surgery 2013, 148: 563-569. PMID: 23571517, PMCID: PMC4392891, DOI: 10.1001/jamasurg.2013.5.Peer-Reviewed Original ResearchConceptsGastric bypassDistal gut microbiomeGut microbiomeWeight lossSurgically Induced Weight LossSurgical weight lossEffect of obesityInduced Weight LossBody mass indexRatio of FirmicutesGut microbiome compositionInfectious colitisBariatric surgeryUlcerative colitisMetabolic syndromeCrohn's diseaseMass indexFurther clinical applicationObese phenotypeWestern dietPubMed searchGut microbiotaEnergy intakeMicrobiome changesHuman gut microbiome
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