2025
Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human
Gronke K, Nguyen M, Fuhrmann H, Santamaria de Souza N, Schumacher J, Pereira M, Löschberger U, Brinkhege A, Becker N, Yang Y, Sonnert N, Leopold S, Martin A, von Münchow-Klein L, Pessoa Rodrigues C, Cansever D, Hallet R, Richter K, Schubert D, Daniel G, Dylus D, Forkel M, Schwinge D, Schramm C, Redanz S, Lassen K, Manfredo Vieira S, Piali L, Palm N, Bieniossek C, Kriegel M. Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human. Science Translational Medicine 2025, 17: eadj6294. PMID: 39908347, DOI: 10.1126/scitranslmed.adj6294.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 8Gut pathobiontsHuman adaptive immune responseLong-term sequelaeAdaptive immune responsesHuman T cellsChronic autoimmune diseaseHuman monocyte activationContribution to autoimmunityAutoimmune hepatitisAutoantibody titersAnti-<i>E.Autoimmune pathophysiologyLupus modelT-helperLifelong immunosuppressionTargeted therapyT cellsDisease activityLupus erythematosusAutoantibody responseMonocyte activationImmune response
2024
OP0047 FASTING MODULATES THE HUMAN GUT MICROBIOME AND REDUCES AN IL-17+/IFNG+ T CELL-INDUCING GUT PATHOBIONT IN PATIENTS WITH RHEUMATOID ARTHRITIS
Pereira M, Stuhlträger K, Effelsberg N, Khokhar A, Redanz S, Ebid H, Hansen B, Laczny C, Löschberger U, Bletz S, Schneider J, Wilmes P, Kessler C, Michalsen A, Mellmann A, Kriegel M. OP0047 FASTING MODULATES THE HUMAN GUT MICROBIOME AND REDUCES AN IL-17+/IFNG+ T CELL-INDUCING GUT PATHOBIONT IN PATIENTS WITH RHEUMATOID ARTHRITIS. Annals Of The Rheumatic Diseases 2024, 83: 51-52. DOI: 10.1136/annrheumdis-2024-eular.3302.Peer-Reviewed Original Research
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