2025
Activity-Dependent Effects of ERK1/2 on Hepatic Ischemia-Reperfusion Injury
Kim J, Hong S, Lee A, Kumar S, Suchi M, Park J. Activity-Dependent Effects of ERK1/2 on Hepatic Ischemia-Reperfusion Injury. Transplantation Proceedings 2025 PMID: 40796392, DOI: 10.1016/j.transproceed.2025.07.005.Peer-Reviewed Original ResearchHepatic ischemia-reperfusion injuryIschemia-reperfusion injuryERK1/2 activationLiver injuryActivity-dependent effectsResponse to IRIEnd-stage liver diseaseDose of trametinibAnalysis of cell death pathwaysEffect of ERK1/2Extracellular signal-regulated kinaseExpression of ferroptosis markersSignal-regulated kinaseSerum markersModulation of ERK1/2 activityLiver transplantationMEK1/2 inhibitorReperfusion timeMolecular analysisRat modelIschemia-reperfusionLiver ischemiaCell death pathwaysHistological assessmentLiver disease
2016
Ketamine accelerates fear extinction via mTORC1 signaling
Girgenti MJ, Ghosal S, LoPresto D, Taylor JR, Duman RS. Ketamine accelerates fear extinction via mTORC1 signaling. Neurobiology Of Disease 2016, 100: 1-8. PMID: 28043916, PMCID: PMC5907920, DOI: 10.1016/j.nbd.2016.12.026.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderMedial prefrontal cortexTreatment of PTSDFear conditioningRetrieval of extinctionExpression of extinctionActivity-dependent effectsTraumatic memoriesStress disorderExtinction exposurePTSD patientsPrefrontal cortexEffects of ketamineGlutamate NMDA receptor antagonistSymptom severityConditioningInfusion of ketamineExtinctionCuesRodent modelsMemoryKetamine administrationReceptor antagonistPresent studyNMDA receptor antagonist
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply