2023
Outcomes after RIC and Abatacept-Based Acute and Chronic Gvhd Prophylaxis in Allogeneic Transplantation for Sickle Cell Disease - Can Calcineurin Inhibitor Use be Curtailed?
Shah N, Ngwube A, Jacobsohn D, Shenoy S. Outcomes after RIC and Abatacept-Based Acute and Chronic Gvhd Prophylaxis in Allogeneic Transplantation for Sickle Cell Disease - Can Calcineurin Inhibitor Use be Curtailed? Blood 2023, 142: 2185. DOI: 10.1182/blood-2023-190524.Peer-Reviewed Original ResearchDisease-free survivalSickle cell diseaseSevere sickle cell diseaseUnrelated donor transplantsGVHD prophylaxisAllogeneic transplantationCell diseaseChronic GVHDDonor transplantsMarrow transplantationGrade 2Unrelated donor stem cell transplantationAllogeneic T cell proliferationDonor stem cell transplantationUnrelated donor marrow transplantationCalcineurin inhibitor useHost disease (GVHD) prophylaxisRelated donor transplantsSevere chronic GVHDSuccessful allogeneic transplantationGroup 1 patientsPhase II trialImmune suppression therapyStem cell transplantationHuman leucocyte antigen
2021
Survival of Patients With Mild Secondary Mitral Regurgitation With and Without Mild Tricuspid Regurgitation
Mori M, Weininger G, Agarwal R, Shang M, Amabile A, Kahler-Quesada A, Yousef S, Pichert M, Vallabhajosyula P, Zhang Y, Sugeng L, Geirsson A. Survival of Patients With Mild Secondary Mitral Regurgitation With and Without Mild Tricuspid Regurgitation. Canadian Journal Of Cardiology 2021, 37: 1513-1521. PMID: 34119634, DOI: 10.1016/j.cjca.2021.06.005.Peer-Reviewed Original ResearchConceptsMild secondary mitral regurgitationLeft ventricular ejection fractionSecondary mitral regurgitationMild tricuspid regurgitationNormal left ventricular ejection fractionTricuspid regurgitationHazard of deathGroup 1Valvular abnormalitiesMitral regurgitationGroup 2Mean age 61 yearsGroup 4Cox proportional hazards modelGroup 1 patientsGroup 2 patientsGroup 3 patientsGroup 4 patientsAge 61 yearsRetrospective cohort studySurvival of patientsSubgroup of patientsProportional hazards modelCohort studyHealth care network
2020
CT Scans Obtained for Nonpulmonary Indications: Associated Respiratory Findings of COVID-19
Hossain R, Lazarus M, Roudenko A, Dako F, Mehta V, Alis J, Zalta B, Lei B, Haramati L, White C. CT Scans Obtained for Nonpulmonary Indications: Associated Respiratory Findings of COVID-19. Radiology 2020, 296: 201743. PMID: 32391741, PMCID: PMC7437495, DOI: 10.1148/radiol.2020201743.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusCoronavirus InfectionsCOVID-19Emergency Service, HospitalFemaleGastrointestinal DiseasesHumansIncidental FindingsLungMaleMiddle AgedPandemicsPneumonia, ViralRadiography, AbdominalRetrospective StudiesSARS-CoV-2Spinal DiseasesSpineTomography, X-Ray ComputedConceptsCoronavirus disease 2019Nonrespiratory symptomsGroup 2Emergency departmentCervical spineCT scanGroup 1CT findingsDisease 2019COVID-19COVID-19-related pneumoniaLung parenchymal findingsPulmonary COVID-19Results Group 1Group 1 patientsCommon CT findingsGround-glass opacitiesReverse transcription-polymerase chain reaction resultsFisher's exact testTranscription-polymerase chain reaction resultsCOVID-19 testingPolymerase chain reaction resultsPulmonary diseaseRT-PCR resultsAtypical manifestations
2012
Selective cerebral perfusion for thoracic aortic surgery: Association with neurocognitive outcome
Uysal S, Lin HM, Fischer GW, Di Luozzo G, Reich DL. Selective cerebral perfusion for thoracic aortic surgery: Association with neurocognitive outcome. Journal Of Thoracic And Cardiovascular Surgery 2012, 143: 1205-1212. PMID: 22306226, DOI: 10.1016/j.jtcvs.2012.01.012.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAorta, ThoracicCardiopulmonary BypassCerebrovascular CirculationChi-Square DistributionCirculatory Arrest, Deep Hypothermia InducedCognitionCognition DisordersFemaleHumansLinear ModelsLogistic ModelsMaleMiddle AgedNeuropsychological TestsNew York CityPerfusionProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsSelective cerebral perfusionHypothermic circulatory arrestSelective cerebral perfusion timeCerebral perfusion timeCardiopulmonary bypass timeThoracic aortic surgeryCerebral perfusionCardiopulmonary bypassCirculatory arrestAortic surgeryBypass timeSurgical patientsNeurocognitive outcomesPerfusion timeHypothermic circulatory arrest timeAortic arch surgeryBrain protection strategiesGroup 3 patientsOptimal brain protectionPostoperative neurocognitive testingGroup 1 patientsGroup 2 patientsThoracic aortic repairCirculatory arrest timeNeurocognitive test scores
2011
Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer
Oh W, Galsky M, Stadler W, Srinivas S, Chu F, Bubley G, Goddard J, Dunbar J, Ross R. Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer. Urology 2011, 78: 626-630. PMID: 21762967, PMCID: PMC3166448, DOI: 10.1016/j.urology.2011.04.041.Peer-Reviewed Original ResearchConceptsCastration-resistant prostate cancerProstate-specific antigenProstate-specific antigen levelIPI-504Retaspimycin hydrochlorideProstate cancerCastration-resistant prostate cancer patientsGroup 2PSA responseMulticenter phase II trialAssociated with unacceptable toxicityGroup 1 patientsGroup 2 patientsPhase II trialHeat shock protein 90 inhibitorSingle-arm trialDocetaxel-treatedRadiographic responseVisceral metastasesChemotherapy regimensTumor burdenBone metastasesPharmacokinetic samplingII trialTumor types
2009
The utility of flow cytometric immunophenotyping in cytopenic patients with a non-diagnostic bone marrow: A prospective study
Truong F, Smith BR, Stachurski D, Cerny J, Medeiros LJ, Woda BA, Wang A. The utility of flow cytometric immunophenotyping in cytopenic patients with a non-diagnostic bone marrow: A prospective study. Leukemia Research 2009, 33: 1039-1046. PMID: 19232722, DOI: 10.1016/j.leukres.2009.01.012.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeCytopenic patientsFlow cytometricPredictive valueGroup 1 patientsGroup 2 patientsHematology outpatient clinicBone marrow aspirateNegative predictive valuePositive predictive valueFCM resultsMedian followMyelomonocytic maturationAbnormal cytogeneticsBM examinationBM diseaseClinical entityOutpatient clinicProspective studyMedical causesMorphological dysplasiaClinical managementMarrow aspiratesIdiopathic cytopeniaPatients
2005
Nitrous Oxide and Laparoscopic Bariatric Surgery
Brodsky J, Lemmens H, Collins J, Morton J, Curet M, Brock-Utne J. Nitrous Oxide and Laparoscopic Bariatric Surgery. Obesity Surgery 2005, 15: 494-496. PMID: 15946427, DOI: 10.1381/0960892053723286.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnesthesia Recovery PeriodAnesthesia, InhalationAnesthetics, InhalationBody Mass IndexDrug Therapy, CombinationFemaleGastric BypassHalothaneHumansLaparoscopyMaleMiddle AgedNitrous OxideObesity, MorbidOxygenProspective StudiesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexTreatment Outcome
2004
Hepatitis C Virus Quasi-Species Dynamics Predict Progression of Fibrosis after Liver Transplantation
Arenas JI, Gallegos-Orozco JF, Laskus T, Wilkinson J, Khatib A, Fasola C, Adair D, Radkowski M, Kibler KV, Nowicki M, Douglas D, Williams J, Netto G, Mulligan D, Klintmalm G, Rakela J, Vargas HE. Hepatitis C Virus Quasi-Species Dynamics Predict Progression of Fibrosis after Liver Transplantation. The Journal Of Infectious Diseases 2004, 189: 2037-2046. PMID: 15143471, DOI: 10.1086/386338.Peer-Reviewed Original ResearchMeSH Keywords5' Untranslated RegionsDisease ProgressionElectrophoresis, Polyacrylamide GelFemaleGenetic VariationHepacivirusHepatitis C, ChronicHumansLiver CirrhosisLiver TransplantationMaleMiddle AgedPhylogenyPolymorphism, Single-Stranded ConformationalReverse Transcriptase Polymerase Chain ReactionRNA, ViralViral Envelope ProteinsConceptsOrthotopic liver transplantationHepatitis C virusLiver transplantationGroup 1Quasi speciesSeverity of recurrenceGroup 1 patientsGroup 2 patientsE2 regionProgression of fibrosisPost-OLT periodCourse of infectionHeteroduplex mobility assayHCV complexityHCV infectionC virusGroup 2PatientsTransplantationSingle-strand conformational polymorphismLiver samplesInfectionWeeksQuasi-species dynamicsYears
2001
The Primary Care Provider and the Care of Skin Disease: The Patient's Perspective
Federman D, Reid M, Feldman S, Greenhoe J, Kirsner R. The Primary Care Provider and the Care of Skin Disease: The Patient's Perspective. JAMA Dermatology 2001, 137: 25-29. PMID: 11176657, DOI: 10.1001/archderm.137.1.25.Peer-Reviewed Original ResearchConceptsPrimary care providersDermatology clinicPrimary careSkin diseasesDermatologist's abilityPatient's perspectiveCare providersSkin problemsVeterans Affairs Medical CenterGroup 1 patientsGroup 2 patientsPrimary care clinicsCross-sectional surveyMost patientsCare clinicsPatient satisfactionSkin biopsiesPCP's abilityMedical CenterPatient confidenceCutaneous surgeryPatientsSkin disordersPrevious careDermatologic care
1995
Optimal timing of coronary artery bypass graft surgery after acute myocardial infarction.
Braxton J, Hammond G, Letsou G, Franco K, Kopf G, Elefteriades J, Baldwin J. Optimal timing of coronary artery bypass graft surgery after acute myocardial infarction. Circulation 1995, 92: ii66-8. PMID: 7586463, DOI: 10.1161/01.cir.92.9.66.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAcute myocardial infarctionQ-wave infarctionArtery bypass graft surgeryNon-Q-wave infarctionBypass graft surgeryMyocardial infarctionGraft surgeryControl groupNon-Q-wave myocardial infarctionIntra-aortic balloon pumpOptimal timingGroup 1 patientsNeed of vasopressorsPerioperative myocardial infarctionWeeks of infarctionAngina refractoryPerioperative MIHospital mortalitySurgical mortalityBalloon pumpControl patientsMedical managementRelative riskHigh risk
1991
Comparison of clinical and electrophysiologic features of preexcitation syndromes in patients presenting initially after age 50 years with those presenting at younger ages
Rosenfeld L, Van Zetta A, Batsford W. Comparison of clinical and electrophysiologic features of preexcitation syndromes in patients presenting initially after age 50 years with those presenting at younger ages. The American Journal Of Cardiology 1991, 67: 709-712. PMID: 2006621, DOI: 10.1016/0002-9149(91)90526-q.Peer-Reviewed Original ResearchConceptsGroup 2 patientsGroup 1 patientsPreexcitation syndromeAtrial fibrillation/flutterAge 50 yearsChronic cardiac diseaseWide complex tachycardiaLate adulthoodInitial arrhythmiaElectrocardiographic evidenceOlder patientsElectrophysiologic featuresElectrophysiologic studyAtrial arrhythmiasQRS intervalSurgical diseaseOrthodromic tachycardiaCardiac diseaseGroup 1PatientsNormal rangeComplex tachycardiaYounger ageElectrocardiographic identificationPrenatal period
1990
Sleep in Postpolio Syndrome
Steljes D, Kryger M, Kirk B, Millar T. Sleep in Postpolio Syndrome. CHEST Journal 1990, 98: 133-140. PMID: 2361379, DOI: 10.1378/chest.98.1.133.Peer-Reviewed Original ResearchConceptsNasal mask ventilationPost-polio patientsGroup 1 patientsNasal CPAPPoor sleep qualityMask ventilationMixed apneaSleep qualityHypoventilation syndromeRespiratory complaintsPercentage stage 1 sleepRapid eye movement (REM) sleepNasal mechanical ventilationNight-time polysomnographyPost-polio symptomsSignificant O2 desaturationGroup 2 patientsRespiratory muscle weaknessNumber of arousalsEye movement sleepImproved sleep qualityPost-polio syndromeStage 1 sleepTotal sleep timeSlow-wave sleep
1989
Differing responses in right and left ventricular filling, loading and volumes during positive end-expiratory pressure
Schulman D, Biondi J, Matthay R, Zaret B, Soufer R. Differing responses in right and left ventricular filling, loading and volumes during positive end-expiratory pressure. The American Journal Of Cardiology 1989, 64: 772-777. PMID: 2679024, DOI: 10.1016/0002-9149(89)90763-7.Peer-Reviewed Original ResearchConceptsPeak filling rateEnd-diastolic volumeLV end-diastolic volumeEjection fractionLeft ventricularCardiac outputRV volumesLV volumesPositive end-expiratory pressure (PEEP) applicationRight ventricular ejection fractionRV end-diastolic volumePositive end-expiratory pressureGroup 1 patientsLow cardiac outputSystemic vascular resistanceVentricular ejection fractionCoronary artery diseaseLV ejection fractionRV ejection fractionEnd-expiratory pressureFilling rateVascular resistanceArtery diseaseBlood pressureVentricular function
1985
A phase I trial of naloxone treatment in acute spinal cord injury.
Flamm E, Young W, Collins W, Piepmeier J, Clifton G, Fischer B. A phase I trial of naloxone treatment in acute spinal cord injury. Journal Of Neurosurgery 1985, 63: 390-7. PMID: 3894597, DOI: 10.3171/jns.1985.63.3.0390.Peer-Reviewed Original ResearchConceptsGroup 2 patientsSpinal cord injuryAcute spinal cord injuryPhase I trialTime of admissionLoading doseCord injuryMaintenance doseI trialExperimental spinal cord injuryComplete neurological deficitGroup 1 patientsWeeks of admissionDose-related fashionTreatment of patientsOpiate antagonist naloxoneIncomplete deficitsMaintenance infusionNeurological deficitsNeurological statusNaloxone treatmentNeurological examinationAntagonist naloxoneInitial doseContinuous infusion
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