2011
Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells
Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Jain D, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ. Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells. European Journal Of Immunology 2011, 41: 2782-2792. PMID: 21660940, PMCID: PMC3517133, DOI: 10.1002/eji.201141678.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalGenes, T-Cell ReceptorGraft RejectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunologic MemoryIsoantigensLymphocyte ActivationMicePostoperative ComplicationsSkin TransplantationT-Cell Antigen Receptor SpecificityT-Lymphocyte SubsetsConceptsEffector memory T cellsMemory T cellsSkin graft rejectionLymphopenia-induced proliferationT cellsMild GVHDAlloreactive clonesGraft rejectionAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationT cell receptor repertoireGVHD effector cellsDonor T cellsStem cell transplantationDiverse T cell receptor repertoireNaive T cellsRapid skin graft rejectionAlloreactive repertoireGVHD inductionLimited GVHDHost diseaseLeukemia effectEffector cellsCell transplantationSyngeneic recipients
2009
T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease
Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu X. T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease. Transplantation And Cellular Therapy 2009, 16: 170-178. PMID: 19804837, PMCID: PMC3876952, DOI: 10.1016/j.bbmt.2009.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBody WeightBone Marrow TransplantationCD3 ComplexCells, CulturedGraft vs Host DiseaseGraft vs Host ReactionInterferon-gammaInterleukin-17MiceMice, Inbred StrainsMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3Severity of Illness IndexSurvival AnalysisT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTh1 CellsTime FactorsTumor Necrosis Factor-alphaWhole Body ImagingConceptsHost diseaseBALB/c recipientsBone marrow transplantation settingAcute Graft-VersusT helper17 cellsGVHD target organsInduction of graftPathogenesis of GVHDCD4 T cellsGraft-VersusGVHD developmentC recipientsT helperTh17 cellsAllogeneic recipientsAutoimmune diseasesC57BL/6 miceSyngeneic recipientsTransplantation settingGVHDT cellsIFN-gammaTarget organsSuperior expansionDisease
2007
A Novel Role for the Semaphorin Sema4D in the Induction of Allo-responses
Duran-Struuck R, Tawara I, Lowler K, Clouthier S, Weisiger E, Rogers C, Luker G, Kumanogoh A, Liu C, Ferrara J, Reddy P. A Novel Role for the Semaphorin Sema4D in the Induction of Allo-responses. Transplantation And Cellular Therapy 2007, 13: 1294.e1-1294.e11. PMID: 17950916, PMCID: PMC2278022, DOI: 10.1016/j.bbmt.2007.07.014.Peer-Reviewed Original ResearchConceptsBone marrow transplantT cellsWT T cellsDendritic cellsBALB/c recipient miceIntrinsic T cell defectPreservation of GVLAllo-immune responsesLess TNF-alphaTumor-free survivalT cell defectsAntigen presenting cellsWild-type T cellsCertain immune responsesP815 murine mastocytoma cell lineT cell-APC interactionsFree survivalHost diseaseIL-12p70Leukemia responseOrgan damageSema4D expressionMarrow transplantCytotoxic functionSyngeneic recipients
1997
Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice
Feldman B, Reid T, Cleary M. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene 1997, 15: 2735-2742. PMID: 9401000, DOI: 10.1038/sj.onc.1201670.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionDisease ProgressionDNA Transposable ElementsGene RearrangementHomeodomain ProteinsLeukemia Virus, MurineLymphomaMiceMice, TransgenicMutagenesisNeoplasm TransplantationOncogene Proteins, FusionProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1RetroviridaeThymus NeoplasmsTransgenesConceptsTransgenic miceMonths of ageE2A-PBX1High-grade T-cell lymphomaE2A-PBX1 transgenic miceT-lineage lymphomasAssociated with tumor progressionT-cell lymphomaDevelopment of lymphomaSite of involvementRetroviral insertional mutagenesisLength of survivalActivated c-MycThymic lymphomasSyngeneic recipientsMonoclonal lymphomaTumor subpopulationsLymphomaTumor progressionRetroviral infectionGenetic eventsNegative cellsLymphomagenesisC-MycRetroviral insertion
1973
SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1973, 137: 239-253. PMID: 4405532, PMCID: PMC2139477, DOI: 10.1084/jem.137.2.239.Peer-Reviewed Original ResearchConceptsThymus-derived cellsAdult syngeneic recipientsAnti-theta antibodyPeripheral lymph nodesNormal adult miceNormal lymphoid tissuesElicit graftGraft-VersusGVH reactionGVH reactivityLymph nodesRecipient spleensSpleen weightSyngeneic recipientsLymphoid tissueSpleen cellsLymphoid cellsAdult miceHost reactionHost responseNormal populationDistinct subpopulationsSubpopulationsFunctional heterogeneitySpleen
1971
Workshop 5 Lymphocyte Recirculation and its Immunological Significance
FORD W, MARCHESI V. Workshop 5 Lymphocyte Recirculation and its Immunological Significance. 1971, 1159-1164. DOI: 10.1016/b978-0-12-057550-3.50091-0.Peer-Reviewed Original ResearchLymphocyte recirculationLymph nodesImmunological significanceEndothelial cellsPeripheral lymphoid tissuesMigration of lymphocytesPost-capillary venulesSyngeneic recipientsRecirculating lymphocytesLymphoid tissueAntigenic stimulationImmunological memorySmall lymphocytesVenular endotheliumInflamed tissuesLymphocytesCapillary venulesLymphocytes adhereTypes of leucocytesLymphEndotheliumBloodTissueNormal circumstancesCells
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