2013
Phosphatidylinositol 3-Kinase–Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice
Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, Gigoux M, Kornete M, Piccirillo C, Suh W, Yu X. Phosphatidylinositol 3-Kinase–Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice. The Journal Of Immunology 2013, 191: 200-207. PMID: 23729441, PMCID: PMC4318500, DOI: 10.4049/jimmunol.1203485.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsDisease Models, AnimalGene Knock-In TechniquesGraft vs Host DiseaseInducible T-Cell Co-Stimulator ProteinLymphocyte ActivationMiceMice, 129 StrainMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicPhosphatidylinositol 3-KinaseSignal TransductionT-Lymphocyte SubsetsConceptsCD8 T cellsCD4 T cellsT cellsHost diseaseWild-type CD8 T cellsCD8 T cell compartmentAllogeneic bone marrow transplantationAcute Graft-VersusPathogenic potentialTotal T cellsAlloreactive T cellsBone marrow transplantationT cell compartmentWild-type T cellsIntracellular calcium mobilizationVivo pathogenic potentialT cell costimulationT cell activationKnockout T cellsAcute graftAcute GVHDGraft-VersusSevere GVHDGVHD modelMarrow transplantation
2004
PLCβ Is Critical for T-Cell Chemotaxis In Vivo.
Bach T, Chen Q, Jordan M, Choi J, Wu D, Koretzky G, Zigmond S, Abrams C. PLCβ Is Critical for T-Cell Chemotaxis In Vivo. Blood 2004, 104: 2650. DOI: 10.1182/blood.v104.11.2650.2650.Peer-Reviewed Original ResearchT cell migrationT cellsChronic inflammationNeutrophil chemotaxisDense inflammatory infiltrateSecondary lymphoid organsWild-type T cellsType T cellsPeripheral T cellsWild-type miceMonths of ageWild-type lymphocytesT cell chemotaxisCytoplasmic calcium concentrationNull T cellsChemotactic responseKnockout T cellsInflammatory infiltrateRecipient miceLymphoid organsInflammatory responseSkin ulcersQuin-2 AMPlasma cellsT lymphocytes
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