2025
Genetic Basis of Gestational Trophoblastic Disease
Hui P. Genetic Basis of Gestational Trophoblastic Disease. 2025, 31-45. DOI: 10.1007/978-3-031-83545-2_3.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorGestational trophoblastic diseaseIntermediate trophoblastTrophoblastic tumorTrophoblastic diseaseHydatidiform MoleEntities of gestational trophoblastic diseaseChorionic-type intermediate trophoblastNeoplastic cellsChorionic villous trophoblastPartial Hydatidiform MoleStage of placental formationTrophoblast cell typesMalignant human cancersGestational choriocarcinomaPlacental formationVillous trophoblastChorion laevePathway of differentiationTumor cellsHyperplastic proliferationCytologic featuresBiomarker expressionProliferative disordersGestational Choriocarcinoma
Hui P. Gestational Choriocarcinoma. 2025, 117-140. DOI: 10.1007/978-3-031-83545-2_9.Peer-Reviewed Original ResearchGestational choriocarcinomaGestational trophoblastic neoplasmsDecidua of pregnancyLethal human cancersTrophoblastic neoplasmsHematogenous spreadMethotrexate chemotherapyChorionic villiPrecursor lesionsMalignant tumorsChoriocarcinomaDestructive growthSurvival rateGestationHuman cancersSarcomaTumorProliferating cellsMortality rateVillous stageChemotherapyMalignancyNeoplasmsDeciduomaPregnancyGestational Trophoblastic Neoplasia (GTN)
Hui P. Gestational Trophoblastic Neoplasia (GTN). 2025, 97-103. DOI: 10.1007/978-3-031-83545-2_7.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorGestational trophoblastic neoplasiaEpithelioid trophoblastic tumorPersistent moleInvasive moleTrophoblastic tumorFederation of Gynecology and Obstetrics (FIGOInternational Federation of Gynecology and Obstetrics (FIGOClinical disease classificationMetastatic moleGestational choriocarcinomaTrophoblastic neoplasiaPrognostic factorsNon-molarTrophoblast processesClinical managementInternational FederationChoriocarcinomaTumorFIGOPregnancyNeoplasiaDisease classificationMolars
2021
Gestational Trophoblastic Neoplasms
Hui P. Gestational Trophoblastic Neoplasms. 2021, 791-820. DOI: 10.1007/978-3-030-84725-8_29.Peer-Reviewed Original ResearchEpithelioid trophoblastic tumorPlacental site nodulePlacental site trophoblastic tumorExaggerated placental site reactionAtypical placental site noduleGestational trophoblastic neoplasiaTrophoblastic tumorGestational choriocarcinomaPersistent gestational trophoblastic neoplasiaEarly chemotherapeutic interventionGestational trophoblastic tumorsGestational trophoblastic neoplasmsBenign reactive conditionsDistinct neoplastic entitySite reactionsTrophoblastic neoplasiaIntermediate trophoblastTrophoblastic neoplasmsPathological diagnosisPrecursor lesionsAncillary studiesNeoplastic entitiesPatient managementHigh indexHistological characteristicsGenotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine
Buza N, Hui P. Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine. Modern Pathology 2021, 34: 1658-1672. PMID: 34088998, DOI: 10.1038/s41379-021-00831-9.Peer-Reviewed Original ResearchConceptsGestational trophoblastic diseaseTrophoblastic diseaseGestational trophoblastic tumorsGestational trophoblastic neoplasiaRoutine diagnostic workupDNA genotypingSignificant clinical relevancePowerful ancillary toolFIGO/Genetic zygosityGestational eventIndex gestationTrophoblastic tumorTrophoblastic neoplasiaGestational choriocarcinomaPrognostic stratificationDiagnostic workupPrognostic assessmentClinical relevanceClinical practiceGestational originMolecular diagnostic capabilitiesPatient careSporadic hydatidiformCopy number alterations
2019
Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women
Buza N, Baine I, Hui P. Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women. Modern Pathology 2019, 32: 1271-1280. PMID: 31028360, DOI: 10.1038/s41379-019-0275-z.Peer-Reviewed Original ResearchConceptsGestational choriocarcinomaLung carcinomaLung massClinical historyLung tumorsGestational originSerum beta-hCG levelsYoung womenTrophoblastic differentiationMetastatic gestational choriocarcinomaSerum beta-hCGBeta-hCG levelsEvidence of diseaseUnique diagnostic challengePrimary lung carcinomaGestational trophoblastic neoplasiaDifferent chemotherapeutic regimensDifferent primary sitesWedge resectionBeta-hCGFemale patientsMetastatic choriocarcinomaThird patientChemotherapeutic regimensImmunophenotypical featuresShort Tandem Repeats Define a Gestational Origin for Metastatic Choriocarcinoma
Brown K, Homer R, Baine M, Blasberg JD. Short Tandem Repeats Define a Gestational Origin for Metastatic Choriocarcinoma. The Annals Of Thoracic Surgery 2019, 108: e115-e117. PMID: 30685255, DOI: 10.1016/j.athoracsur.2018.12.038.Peer-Reviewed Original ResearchConceptsPlacenta accretaSpontaneous hemothoraxGestational choriocarcinomaLower lobe massMetastatic gestational choriocarcinomaHealthy female patientsAdjuvant therapyMetastatic choriocarcinomaSurgical explorationChief complaintFemale patientsOutside hospitalRare consequenceUnreported causeGestational originClinical implicationsChoriocarcinomaAccretaHemothoraxResectionPatientsPrognosisHospitalShortnessTherapy
2018
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology
Hui P. Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology. Archives Of Pathology & Laboratory Medicine 2018, 143: 65-74. PMID: 30407075, DOI: 10.5858/arpa.2018-0234-ra.Peer-Reviewed Original ResearchConceptsGestational trophoblastic tumorsTrophoblastic tumorPersistent gestational trophoblastic neoplasiaPlacental site trophoblastic tumorAtypical placental site noduleEarly chemotherapeutic interventionPlacental site noduleEpithelioid trophoblastic tumorGestational trophoblastic neoplasiaClinical featuresGestational choriocarcinomaTrophoblastic neoplasiaHistologic characteristicsPathologic diagnosisClinical managementPrecursor lesionsHigh indexClinical practiceAccurate diagnosisTumorsChemotherapeutic interventionSurveillance programDistinct entityMolecular biomarkersDiagnostic recognition
2016
Putative Precursor Lesions of Gestational Trophoblastic Neoplasia
Buza N, Hui P. Putative Precursor Lesions of Gestational Trophoblastic Neoplasia. 2016, 85-102. DOI: 10.1007/978-3-319-22509-8_5.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorPlacental site nodulePrecursor lesionsTrophoblastic tumorRare caseAtypical placental site noduleRisk of progressionExaggerated placental siteGestational trophoblastic neoplasiaGestational trophoblastic neoplasmsSignificant cytological atypiaHistological diagnostic criteriaMajority of tumorsPossible precursor lesionsPutative precursor lesionsIntraplacental choriocarcinomaEctopic pregnancyTerm pregnancyTrophoblastic neoplasiaGestational choriocarcinomaNon-molar abortionsPlacental siteTrophoblastic neoplasmsCytological atypia
2014
Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament
Buza N, Rutherford T, Hui P. Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament. International Journal Of Gynecological Pathology 2014, 33: 58-63. PMID: 24300537, DOI: 10.1097/pgp.0b013e31827cd386.Peer-Reviewed Original ResearchConceptsBroad ligamentFallopian tubePelvic lymph node metastasisMultiagent chemotherapy regimenRecurrence 26 monthsRight adnexal massRight fallopian tubeLymph node metastasisOnly necrotic tissueLast menstrual periodLarge tumor massMicroscopic examinationChemotherapy regimenEctopic pregnancyMultiagent chemotherapyNongestational choriocarcinomaPure choriocarcinomaNode metastasisPatient ageInitial diagnosisInitial presentationGestational choriocarcinomaAdnexal massesFinal diagnosisEmergency room
2011
Gestational Choriocarcinoma
Hui P. Gestational Choriocarcinoma. Current Clinical Pathology 2011, 127-137. DOI: 10.1007/978-1-61779-394-3_8.Peer-Reviewed Original ResearchGestational choriocarcinomaMalignant tumorsMethotrexate-based chemotherapyMortality of patientsDecidua of pregnancyHematogenous spreadCure rateFatal malignancyTrophoblastic diseaseChemotherapy managementAggressive formChoriocarcinomaChorial villiTumorsTumor cellsSarcomaDiseaseChemotherapyPatientsPregnancyDramatic decreaseMalignancyMortalityPlacentaDeciduaGenetic Basis of Gestational Trophoblastic Disease
Hui P. Genetic Basis of Gestational Trophoblastic Disease. Current Clinical Pathology 2011, 41-55. DOI: 10.1007/978-1-61779-394-3_3.Peer-Reviewed Original ResearchGestational trophoblastic diseasePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastTrophoblastic diseaseExaggerated placental site reactionChorionic villous trophoblastPlacental site noduleUnique clinical settingGestational choriocarcinomaSite reactionsMalignant tumorsLesional cellsProliferative lesionsProliferative disordersTrophoblastic cellsVillous trophoblastBiomarker expressionClinical settingImplantation sitesTumorsUnique genetic factorsRecent linkage studiesComplete hydatidiform
2010
Gestational trophoblastic disease: histopathological diagnosis in the molecular era
Buza N, Hui P. Gestational trophoblastic disease: histopathological diagnosis in the molecular era. Diagnostic Histopathology 2010, 16: 526-537. DOI: 10.1016/j.mpdhp.2010.08.002.Peer-Reviewed Original ResearchGestational trophoblastic diseaseTrophoblastic diseaseTrophoblastic tumorCharacteristic histological featuresExaggerated placental sitePlacental site noduleEpithelioid trophoblastic tumorTumor-like conditionsFuture diagnostic algorithmsDiagnosis of hydatidiformUnique neoplasmGestational choriocarcinomaPlacental siteHistological featuresHistopathological diagnosisDifferential diagnosisDiagnostic criteriaMolecular testingPlacental trophoblastsProliferative disordersDiagnostic algorithmDiagnosisPartial hydatidiformHeterogeneous groupDiagnostic problemsGestational Trophoblastic Disease
Chhieng D, Hui P. Gestational Trophoblastic Disease. Current Clinical Pathology 2010, 131-138. DOI: 10.1007/978-1-60761-164-6_8.Peer-Reviewed Original ResearchTumors of Peritoneum
Chhieng D, Hui P. Tumors of Peritoneum. Current Clinical Pathology 2010, 193-207. DOI: 10.1007/978-1-60761-164-6_12.Peer-Reviewed Original ResearchPeritoneal serous carcinomaTumor-like conditionsTrophoblastic tumorSerous carcinomaPrimary peritoneal serous carcinomaIntermediate trophoblastic tumorGestational trophoblastic tumorsPrimary peritoneal tumorsFrequent differential diagnosisSecondary Mullerian systemExtraovarian primaryOvarian primaryParenchymal involvementMullerian systemBorderline tumorsPeritoneal tumorsSignificant morbidityDiffuse involvementMetastatic carcinomaGestational choriocarcinomaCommon tumorsMucinous lesionsReproductive yearsDifferential diagnosisDiagnostic criteria
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