2016
Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease
Montenont E, Echagarruga C, Allen N, Araldi E, Suarez Y, Berger JS. Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease. Blood 2016, 128: 2033-2042. PMID: 27609643, PMCID: PMC5073182, DOI: 10.1182/blood-2016-03-703157.Peer-Reviewed Original ResearchConceptsPlatelet activityCardiovascular diseaseMEG-01 cellsHyperreactive platelet phenotypeBasal intracellular calcium concentrationPathogenesis of atherothrombosisSex-matched controlsIntracellular calcium concentrationMessenger RNAMEG-01Healthy controlsClinical significancePlatelet-related genesPlatelet phenotypeBasal stateMegakaryoblastic cell line MEG-01Human megakaryoblastic cell line MEG-01Thrombin activationDiseaseCalcium concentrationKD phenotypeProtein levelsF-actin contentPlatelet messenger RNAPlatelet RNA
1991
Modulation of Neonatal Neutrophil Function by Pentoxifylline
Krause P, Maderazo E, Contrino J, Eisenfeld L, Herson V, Greca N, Bannon P, Kreutzer D. Modulation of Neonatal Neutrophil Function by Pentoxifylline. Pediatric Research 1991, 29: 123-127. PMID: 2014147, DOI: 10.1203/00006450-199102000-00002.Peer-Reviewed Original ResearchConceptsPMN functionNitroblue tetrazolium reductionImpaired PMN functionsNeonatal neutrophil functionTetrazolium reductionTreatment of infectionsPolymorphonuclear leukocyte chemotaxisF-actin contentDose-dependent effectPotential clinical useCertain disease processesSimilar dose-dependent responseDose-dependent responseNeutrophil functionNewborn infantsPMN activityPMN deformabilityPMN chemotaxisDisease processPentoxifyllineLeukocyte chemotaxisMethylxanthine pentoxifyllinePhagocytic activityNeonatesClinical use
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