2024
Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways
Binder M, Escobar I, Xu Y, Sokolov A, Zhang L, Bordey A. Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways. Journal Of Neuroscience 2024, 44: e1245232024. PMID: 39164108, PMCID: PMC11426378, DOI: 10.1523/jneurosci.1245-23.2024.Peer-Reviewed Original ResearchPup isolation callsFilamin AIsolation callsAutism spectrum disorderSigns of autism spectrum disorderPyramidal neuronsConstitutively active mutantCommunication deficitsDownstream of ERK1/2MTOR complex 1Actin crosslinkingSynaptic connectionsExpression of RhebSpine densityActive mutantActive RhebCore pathwaysRhebCortical synaptic connectivityCellular mosaicismConstitutively active RhebOne-month-old miceExcitatory synaptic activityNeocortex of miceSocial communicationThe mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
Nguyen L, Xu Y, Nair M, Bordey A. The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. ELife 2024, 12: rp91010. PMID: 38411613, PMCID: PMC10942629, DOI: 10.7554/elife.91010.Peer-Reviewed Original ResearchConceptsMouse medial prefrontal cortexMedial prefrontal cortexFocal malformations of cortical developmentMalformations of cortical developmentExcitatory synaptic activityExcitatory synaptic transmissionCortical neuron developmentPyramidal neuron morphologyMechanisms of hyperexcitabilityResponse to therapeutic interventionsMTORC1 signalingGene-specific mechanismsPrefrontal cortexFocal malformationsBrain somatic mutationsMTOR complex 1Membrane excitabilityBiallelic inactivationClinical manifestationsGene mutationsNetwork hyperexcitabilitySynaptic transmissionSynaptic activityIntractable epilepsyRepressor geneThe mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
Nguyen L, Xu Y, Nair M, Bordey A. The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. ELife 2024, 12 DOI: 10.7554/elife.91010.3.Peer-Reviewed Original ResearchMouse medial prefrontal cortexMedial prefrontal cortexFocal malformations of cortical developmentMalformations of cortical developmentExcitatory synaptic activityExcitatory synaptic transmissionCortical neuron developmentPyramidal neuron morphologyMechanisms of hyperexcitabilityResponse to therapeutic interventionsMTORC1 signalingGene-specific mechanismsPrefrontal cortexFocal malformationsBrain somatic mutationsMTOR complex 1Membrane excitabilityBiallelic inactivationClinical manifestationsGene mutationsNetwork hyperexcitabilitySynaptic transmissionSynaptic activityIntractable epilepsyRepressor gene
2011
Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences
Huang H, Xu Y, van den Pol AN. Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. Journal Of Neurophysiology 2011, 106: 1191-1202. PMID: 21653710, PMCID: PMC3174824, DOI: 10.1152/jn.00740.2010.Peer-Reviewed Original ResearchConceptsAnorexigenic proopiomelanocortin (POMC) neuronsPOMC cellsNPY neuronsProopiomelanocortin neuronsOrexigenic neuropeptide Y (NPY) neuronsHypocretin/orexin neuronsWeight lossNeuropeptide Y cellsWeight-reducing actionsNeuropeptide Y neuronsExcitatory synaptic activityPrevalence of obesityHypothalamic arcuate nucleusΑ4β2 nicotinic receptorsBiggest health problemsSimilar actionsAttenuates ObesityCell typesY neuronsOrexin neuronsCholinergic axonsMembrane potentialNPY cellsArcuate nucleusNicotine action
1996
Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices.
Bordey A, Feltz P, Trouslard J. Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices. The Journal Of Physiology 1996, 497: 175-187. PMID: 8951720, PMCID: PMC1160921, DOI: 10.1113/jphysiol.1996.sp021758.Peer-Reviewed Original ResearchConceptsSpontaneous excitatory postsynaptic currentsCentral autonomic areaSympathetic preganglionic neuronesSpinal cord slicesGlutamate-induced currentsAutonomic areasCord slicesTransverse thoracolumbar spinal cord slicesAgonist rank order potencyAction potentialsRat spinal cord slicesWhole-cell patch-clamp techniqueNicotinic acetylcholine receptor agonistExcitatory synaptic activityPresence of tetrodotoxinAcetylcholine receptor agonistExcitatory postsynaptic currentsMembrane current noisePatch-clamp techniqueCurrent-clamp conditionsDetectable current responseRank order potencySEPSC amplitudeVoltage-clamp conditionsStrong inward rectification
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