2008
Limited Efficacy and Unacceptable Toxicity of Cyclophosphamide for the Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys
Sogawa H, Boskovic S, Nadazdin O, Abrahamian G, Colvin R, Sachs D, Cosimi A, Kawai T. Limited Efficacy and Unacceptable Toxicity of Cyclophosphamide for the Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys. Transplantation 2008, 86: 615-619. PMID: 18724233, PMCID: PMC2786005, DOI: 10.1097/tp.0b013e3181821bac.Peer-Reviewed Original ResearchConceptsTotal body irradiationRenal allograft toleranceInduction of mixed chimerismTotal body irradiation groupMixed chimerismAllograft toleranceCynomolgus monkeysCD154 blockadeAbsolute B-cell countNonmyeloablative conditioning regimenB-cell countsB-cell lymphomaToxicity of cyclophosphamideDose-dependent neutropeniaLong-term survivalConditioning regimenNonmyeloablative regimenMultilineage chimerismHematopoietic recoveryBody irradiationToxicity of CPLimited efficacyCyclophosphamideTotal doseChimerism
2004
CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates
Kawai T, Sogawa H, Boskovic S, Abrahamian G, Smith R, Wee S, Andrews D, Nadazdin O, Koyama I, Sykes M, Winn H, Colvin R, Sachs D, Cosimi A. CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates. American Journal Of Transplantation 2004, 4: 1391-1398. PMID: 15307826, DOI: 10.1111/j.1600-6143.2004.00523.x.Peer-Reviewed Original ResearchConceptsDonor bone marrowCD154 blockadeCostimulatory blockadeMixed chimerismAllograft toleranceAllograft survivalLong-term survival of renal allograftsDonor bone marrow engraftmentInduce renal allograft toleranceInduction of mixed chimerismInduction of allograft toleranceIncidence of acute rejectionProlonged renal allograft survivalAnti-CD154 monoclonal antibodySurvival of renal allograftsLate chronic rejectionDiscontinuation of immunosuppressionRenal allograft toleranceTransient mixed chimerismRenal allograft survivalEvidence of rejectionNonhuman primatesLong-term survivalLong-term survivorsConditioning regimen
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