2025
evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer’s disease
Cummings J, Atri A, Feldman H, Hansson O, Sano M, Knop F, Johannsen P, León T, Scheltens P. evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer’s disease. Alzheimer's Research & Therapy 2025, 17: 14. PMID: 39780249, PMCID: PMC11708093, DOI: 10.1186/s13195-024-01666-7.Peer-Reviewed Original ResearchConceptsSymptomatic ADAlzheimer's diseaseDouble-blindGlucagon-like peptide-1 receptor agonist semaglutidePlacebo-controlled phase 3 trialOnce-daily oral semaglutideClinical Dementia RatingMild cognitive impairmentAD-related processesAD biomarkersSafety of semaglutideDose-escalation regimenPhase 3 studyBaseline to weekEffect of semaglutidePhase 3 trialCognitive impairmentPathophysiology of Alzheimer's diseasePotential disease-modifying effectsDementia RatingSymptomatic Alzheimer's diseaseTreatment of type 2 diabetesPlacebo-ControlledType 2 diabetesDisease-modifying potentialThe WAVE complex in developmental and adulthood brain disorders
Kim H, Berdasco C, Nairn A, Kim Y. The WAVE complex in developmental and adulthood brain disorders. Experimental & Molecular Medicine 2025, 57: 13-29. PMID: 39774290, PMCID: PMC11799376, DOI: 10.1038/s12276-024-01386-w.Peer-Reviewed Original ResearchConceptsWiskott-Aldrich syndrome protein family verprolin-homologous proteinActin polymerizationCellular processesArp2/3 complex-mediated actin polymerizationRegulatory proteinsOrganization of actin filamentsMaintenance of neuronal plasticityBrain disordersActin regulatory proteinsAutism spectrum disorderPathophysiology of Alzheimer's diseaseDe novo mutationsIntellectual disabilityActin filamentsExtracellular cuesSpectrum disorderMaladaptive feedingDevelopmental disordersAging BrainHeteropentameric complexNeuronal plasticityIntracellular signalingIntracellular eventsBehavioral adaptationsDisorders
2024
Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
Huang Y, Wang M, Ni H, Zhang J, Li A, Hu B, Junqueira Alves C, Wahane S, Rios de Anda M, Ho L, Li Y, Kang S, Neff R, Kostic A, Buxbaum J, Crary J, Brennand K, Zhang B, Zou H, Friedel R. Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease. Nature Neuroscience 2024, 27: 1489-1504. PMID: 38802590, PMCID: PMC11346591, DOI: 10.1038/s41593-024-01664-w.Peer-Reviewed Original ResearchPlexin-B1Alzheimer's diseaseGlial netsNetwork hub genesLate-onset ADPlaque-associated astrocytesPathophysiology of Alzheimer's diseaseMouse AD modelPlaque compactionNeuritic dystrophyHub genesGuidance receptorsTranscriptional changesAD modelAmyloid depositsAmyloidReducing neuroinflammationGlial cellsReactive astrocytesReceptor Plexin-B1Net activityGlial processesDeletionGenesCell distance
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