Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial
Khoudary S, Zhao Q, Venugopal V, Manson JE, Brooks MM, Santoro N, Black DM, Harman SM, Cedars MI, Hopkins PN, Kearns AE, Miller VM, Taylor HS, Budoff MJ. Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial. Journal Of The American Heart Association 2019, 8: e012763. PMID: 31652073, PMCID: PMC6761637, DOI: 10.1161/jaha.119.012763.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenConjugated equine estrogensCoronary artery calcification (CAC) progressionBaseline CAC scoreEpicardial adipose tissueCAC scoreEquine estrogensMenopausal womenCAC progressionCalcification progressionAdipose tissueEpicardial adipose tissue accumulationEarly menopausal womenPlacebo-controlled trialAdipose tissue accumulationHormone therapy formulationsProgression of CACKEEP participantsHormone therapySubclinical atherosclerosisCAC measuresEndogenous estrogensFat accumulationTreatment groupsFat depots
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