2010
Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens
Burton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, Cooke A, Zaccone P. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. European Journal Of Immunology 2010, 40: 2221-2229. PMID: 20480503, DOI: 10.1002/eji.200939998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, HelminthCD4-Positive T-LymphocytesCells, CulturedFemaleForkhead Transcription FactorsGalectin 3Helminth ProteinsHost-Pathogen InteractionsImmunomodulationLectins, C-TypeMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutMinor Histocompatibility AntigensReceptors, Cell SurfaceSchistosoma mansoniToll-Like Receptor 2Transforming Growth Factor betaConceptsS. mansoni soluble egg antigenSchistosoma mansoni antigensT cellsFoxp3 expressionImportance of TLR2S. mansoni antigensSurface-bound TGFTLR2 ligand stimulationT cell secretionAccessory cell interactionsNOD miceTh2 responsesEgg antigenImmunomodulatory effectsT lymphocytesAbsence of APCC-type lectinBioactive TGFGalectin-3AntigenTGFTLR2Cell interactionsCellsLigand stimulation
2008
Schistosoma mansoni Triose Phosphate Isomerase Peptide MAP4 is Able to Trigger Naïve Donor Immune Response Towards a Type‐1 Cytokine Profile
Reis E, Carmo T, Athanazio R, Reis M, Harn D. Schistosoma mansoni Triose Phosphate Isomerase Peptide MAP4 is Able to Trigger Naïve Donor Immune Response Towards a Type‐1 Cytokine Profile. Scandinavian Journal Of Immunology 2008, 68: 169-176. PMID: 18565118, DOI: 10.1111/j.1365-3083.2008.02131.x.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsSchistosoma mansoni soluble egg antigenDendritic cellsCytokine productionAutologous peripheral blood mononuclear cellsType 1 cytokine profileMonocyte-derived dendritic cellsDonor dendritic cellsDonor immune responsesTh1-type responseT cell subsetsBlood mononuclear cellsIFN-gamma productionT cell epitopesMultiple antigen peptideMajor cell populationRecall stimulationCytokine profileIL-10Egg antigenMononuclear cellsT cellsImmune responseIFN-gammaMouse modelPotential immunomodulatory effects of plant lectins in Schistosoma mansoni infection
Reis EA, Athanazio DA, Cavada BS, Teixeira EH, de Paulo Teixeira Pinto V, Carmo TM, Reis A, Trocolli G, Croda J, Harn D, Barral-Netto M, Reis MG. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica 2008, 108: 160-165. PMID: 18579103, DOI: 10.1016/j.actatropica.2008.05.025.Peer-Reviewed Original ResearchConceptsPatients' peripheral blood mononuclear cellsPeripheral blood mononuclear cellsCytokine productionElevated IL-5 productionTh2-like cytokine responseIL-5 productionSchistosoma mansoni infectionStimulation ex vivoTh2-like responseBlood mononuclear cellsPotential immunomodulatory effectsSoluble egg antigenExperimental murine modelTh2 environmentPBMC supernatantsIL-10Mansoni infectionCytokine responsesEgg antigenImmunomodulatory effectsMononuclear cellsInfected patientsIL-5TNF-alphaLymphocyte stimulator
2007
Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens
Reis E, Azevedo T, McBride A, Harn D, Reis M. Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens. Scandinavian Journal Of Immunology 2007, 66: 662-670. PMID: 18021364, DOI: 10.1111/j.1365-3083.2007.02024.x.Peer-Reviewed Original ResearchConceptsSchistosoma mansoni soluble egg antigenNaïve human peripheral blood mononuclear cellsSoluble egg antigenIL-10Egg antigenIL-5T cellsT helper cell responsesHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsDonor dendritic cellsTh2-type responseTh2-like responseBlood mononuclear cellsPronounced CD4Dendritic cellsIL-12p40Immune suppressionIL-6Mononuclear cellsCytokine secretionDonor responsesIFN-gammaCD4Day 7
2004
Serodiagnosis of Schistosoma mansoni infections in an endemic area of Burkina Faso: performance of several immunological tests with different parasite antigens
Sorgho H, Bahgat M, Poda J, Song W, Kirsten C, Doenhoff M, Zongo I, Ouédraogo J, Ruppel A. Serodiagnosis of Schistosoma mansoni infections in an endemic area of Burkina Faso: performance of several immunological tests with different parasite antigens. Acta Tropica 2004, 93: 169-180. PMID: 15652331, DOI: 10.1016/j.actatropica.2004.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, HelminthAntigens, HelminthBurkina FasoChildCross-Sectional StudiesEndemic DiseasesEnzyme-Linked Immunosorbent AssayFecesFemaleFluorescent Antibody Technique, IndirectHemagglutination TestsHumansMaleParasite Egg CountSchistosoma mansoniSchistosomiasis mansoniConceptsIndirect haemagglutination assayEnzyme-linked immunosorbent assaySoluble S. mansoni egg antigensEgg antigenS. japonicum egg antigenKato-Katz thick smearsAdult S. mansoni wormsSchistosoma mansoni-endemic areaS. mansoni egg antigensS. mansoni adult wormsS. mansoni eggsSchistosoma mansoni infectionEgg-negative individualsS. mansoni wormsSensitive diagnostic markerSecond stool sampleIndirect immunofluorescent antibodyDifferent parasite antigensResource-poor settingsAccurate diagnostic testSensitivity of ELISAMansoni eggsMansoni infectionWorm antigenTrue infection
1996
Function and expression of a human idiotypic network in Schistosomiasis japonica
WISNEWSKI A, OLDS G, JOHNSON J, RAMIREZ B, KRESINA T. Function and expression of a human idiotypic network in Schistosomiasis japonica. Parasite Immunology 1996, 18: 439-447. PMID: 9226679, DOI: 10.1111/j.1365-3024.1996.tb01027.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibodies, Anti-IdiotypicAntibodies, HelminthAntibodies, HeterophileAntigens, HelminthChildFemaleGranulomaHumansImmunoglobulin GImmunoglobulin IdiotypesIn Vitro TechniquesLymphocyte ActivationMiceOvumPregnancySchistosoma japonicumSchistosomiasis japonicaSolubilityT-LymphocytesConceptsS. japonicum soluble egg antigensAnti-idiotypic antibodiesSchistosomiasis japonicaHuman anti-idiotypic antibodySoluble egg antigenNon-related antigensAnti-idiotypic antiseraS. japonicum infectionHuman lymphocyte blastogenesisCross-reactive idiotypeDose-dependent mannerHepatosplenic diseaseAcute infectionSerum levelsBlastogenic responseLymphocyte blastogenesisEgg antigenImmunoregulatory networkGranuloma formationJaponicum infectionFormation assaysS. japonicumAntibodiesAntigenDependent manner
1994
Induction Of Hepatic Pathology In Scid-Hu Mice Engrafted With Peripheral Blood Lymphocytes Of Patients With Schistosomiasis Japonica
Kresina T, Wisnewski A, Love-Homan L, Ramirez B, Neil G. Induction Of Hepatic Pathology In Scid-Hu Mice Engrafted With Peripheral Blood Lymphocytes Of Patients With Schistosomiasis Japonica. The Journal Of Infectious Diseases 1994, 170: 733-736. PMID: 8077739, DOI: 10.1093/infdis/170.3.733.Peer-Reviewed Original ResearchConceptsPeripheral blood lymphocytesSCID-hu miceHepatic pathologyBlood lymphocytesActivation of PBLSerum profileSoluble worm antigenic preparationTh1 phenotype cytokinesTh2 phenotype cytokinesInflammatory cell infiltrateSoluble egg antigenHuman immune responseSchistosomiasis japonica infectionHuman cytokine profilesCytokine profileCell infiltrateEgg antigenClinical examinationIL-4SCID miceImmune responseGamma interferonSpecific cytokinesSchistosomiasis japonicaAntigenic preparationsHuman monoclonal antibodies heterogeneously express a human cross-reactive idiotype associated with immune function in Schistosoma japonicum infection.
Wisnewski AV, Olds GR, Kresina TF. Human monoclonal antibodies heterogeneously express a human cross-reactive idiotype associated with immune function in Schistosoma japonicum infection. Human Antibodies 1994, 5: 178-82. PMID: 7756581.Peer-Reviewed Original ResearchConceptsHuman monoclonal antibodyEpstein-Barr virusSchistosoma japonicum infectionCross-reactive idiotypeJaponicum infectionImmune functionMonoclonal antibodiesSoluble egg antigenS. japonicum infectionWestern blot profilesSchistosomiasis patientsBarr virusEgg antigenHuman idiotypeIdiotype expressionReactive idiotypeMultiple antigensSerological analysisS. japonicumIdiotypeInfectionAntigenHeterogeneous expressionLevel of suppressionPatients
1992
Human Hybridoma Generation by Hypo-Osmolar Electrofusion: Characterization of Human Monoclonal Antibodies to Schistosoma mansoni Parasite Antigens
Klock G, Wisnewski AV, el-Bassiouni EA, Ramadan MI, Gessner P, Zimmermann U, Kresina TF. Human Hybridoma Generation by Hypo-Osmolar Electrofusion: Characterization of Human Monoclonal Antibodies to Schistosoma mansoni Parasite Antigens. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1992, 11: 469-481. PMID: 1398684, DOI: 10.1089/hyb.1992.11.469.Peer-Reviewed Original ResearchConceptsHuman monoclonal antibodyMonoclonal antibodiesIgG antibodiesParasite antigensHypo-osmolar electrofusionS. mansoniSchistosoma mansoni wormsCell linesWestern blot analysisEgg antigenParasitic antigensAntigen reactivityAntigenAntibodiesSplenocytesBlot analysisHybridomasCandidate moleculesMansoniHybridoma generationMitogenCell fusionSomatic cell fusionGreater numberELISA
1991
Screening of murine monoclonal antibodies against living schistosomula of Schistosoma mansoni by radioimmunoassay
Wiest P, Wisnewski A, Johnson J, Ramirez B, Kresina T, Olds G. Screening of murine monoclonal antibodies against living schistosomula of Schistosoma mansoni by radioimmunoassay. International Journal For Parasitology 1991, 21: 449-454. PMID: 1917285, DOI: 10.1016/0020-7519(91)90102-d.Peer-Reviewed Original ResearchConceptsMurine monoclonal antibodiesSurface antigenSoluble adult worm antigenSchistosoma mansoniMonoclonal antibodiesS. mansoni paramyosinS. mansoni infectionSoluble egg antigenAdult worm antigenEnzyme-linked immunosorbentMansoni infectionEgg antigenLung stageWorm antigenS. mansoniSecrete antibodiesAntigenSchistosomulaAdult wormsAntibodiesRadioimmunoassayMansoniImmunoblot analysisOld parasitesMurine hybridomasAn immunoregulatory human monoclonal antibody in schistosomiasis japonica
Kresina T, Guan X, Posner M, Wisnewski A, Olds G. An immunoregulatory human monoclonal antibody in schistosomiasis japonica. Human Antibodies 1991, 2: 42-45. PMID: 1651785, DOI: 10.3233/hab-1991-2107.Peer-Reviewed Original ResearchConceptsHuman monoclonal antibodyMonoclonal antibodiesEgg antigenAntigen-induced blastogenesisAdult wormsEpstein-Barr virusSoluble egg antigenOS cell linesWestern blot analysisChronic schistosomiasisSoluble eggBarr virusChinese patientsChronic diseasesAntibody-producing hybridomasAntigen reactivitySchistosomiasis japonicaCarbohydrate antigensWestern blotDecompression operationMurine splenocytesSplenocytesAntibodiesAntigenSchistosoma japonicum
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