2024
Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children
Goodwin J, Kajubi R, Wang K, Li F, Wade M, Orukan F, Huang L, Whalen M, Aweeka F, Mwebaza N, Parikh S. Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children. Nature Communications 2024, 15: 3817. PMID: 38714692, PMCID: PMC11076639, DOI: 10.1038/s41467-024-48210-7.Peer-Reviewed Original ResearchConceptsDay 7 lumefantrine concentrationsArtemether-lumefantrine treatmentRing-stage parasitesEarly post-treatmentEarly post-treatment periodArtemether-lumefantrineArtemisinin resistanceDay regimenMulticlonal infectionsEfficacious therapyFollow-upRandomized trialsPersistent clonesTransmission settingsEffective treatmentPost-treatment periodRegimensAntimalarial studiesStandard diagnosticsStandard 3DaysPost-treatmentChildrenTreatmentTherapyWhat Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis?
Vitale A, Angelico R, Sensi B, Lai Q, Kauffmann E, Scalera I, Serenari M, Ginesini M, Romano P, Furlanetto A, D’Amico F. What Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis? Cancers 2024, 16: 966. PMID: 38473327, PMCID: PMC10930835, DOI: 10.3390/cancers16050966.Peer-Reviewed Original ResearchMinimally invasive liver surgeryOpen surgeryLiver surgerySignificant cardiovascular riskTrans-arterial approachResection outcomesLaparoscopic ablationResected casesLiver transplantationTreated patientsHepatocellular carcinomaEfficacious therapyCardiovascular riskSurgeryPatientsNarrative reviewTreatment hierarchyCurative techniqueHCCResectionCarcinomaCirrhosisTransplantationTherapy
2023
Chapter 1 Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration
Nasonkin I, Rizzolo L. Chapter 1 Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration. 2023, 1-41. DOI: 10.1016/b978-0-323-99987-8.00005-9.Peer-Reviewed Original ResearchStem cellsDifferent ocular tissuesActual clinical impactClinical translationEndogenous stem cellsCell transplantationVision lossEfficacious therapyClinical impactAnimal modelsOcular tissuesHuman patientsImpaired visionOcular repairPatientsClinicBench discoveriesTissue stem cellsLimited proliferationOrganoid culturesCellsInitial excitementTransplantationTherapy
2021
Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells
Li Y, Harunori O, Fu S, Xing F, Wu H, Wang J, Chen A, Ren X, Peng D, Ling X, Shi M, Wu H. Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells. Aging 2021, 13: 20131-20148. PMID: 34461606, PMCID: PMC8436936, DOI: 10.18632/aging.203279.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAgedAntigensCD3 ComplexCD56 AntigenCD8-Positive T-LymphocytesCell Culture TechniquesHealth StatusHumansImmune SystemImmunityImmunotherapyKiller Cells, NaturalLeukocytes, MononuclearLymphomaMiddle AgedNeoplasmsPancreatic NeoplasmsProgrammed Cell Death 1 ReceptorReceptors, IgGT-Lymphocytes, Helper-InducerTreatment OutcomeConceptsPeripheral blood mononuclear cellsPD-1<sup>+</sup> T cellsProgrammed cell death protein 1Sub-healthy individualsNKM cellsImmune normalizationT cellsCD8<sup>+</sup>PD-1<sup>+</sup> T cellsCancer patientsCell death protein 1Proportion of NK cellsProportion of T helper cellsPeripheral immune systemT helper cellsBlood mononuclear cellsPotential clinical applicationsMalignant lymphomaNK cellsAdjuvant treatmentKiller cellsPancreatic cancerMononuclear cellsEfficacious therapyCancer preventionSide effectsLeveraging behavioral economics to promote treatment adherence: A primer for the practicing dermatologist
Woodbury MJ, Cohen JM, Merola JF, Perez-Chada LM. Leveraging behavioral economics to promote treatment adherence: A primer for the practicing dermatologist. Journal Of The American Academy Of Dermatology 2021, 87: 1075-1080. PMID: 34098000, DOI: 10.1016/j.jaad.2021.05.049.Peer-Reviewed Original ResearchConceptsTreatment adherenceSuboptimal clinical outcomesSuboptimal treatment adherenceQuality of lifeLifestyle modificationMedical therapyClinical outcomesDermatologic patientsPatient adherenceChronic diseasesEfficacious therapyEconomic burdenHealth behaviorsUnmet needScalable interventionsHealth policyAdherenceHealth carePatientsTherapyDiseaseNonadherencePsoriasisDearth of researchPubMed
2016
Somatic Mosaicism in Blaschkolinear Inflammatory Disorders
Theodosakis N, Levy L, Cowper S, Lazova R, Kugelman L, Zubek A, Choate K. Somatic Mosaicism in Blaschkolinear Inflammatory Disorders. Journal Of Clinical & Experimental Dermatology Research 2016, 2016: 1000356. PMID: 36267522, PMCID: PMC9581078, DOI: 10.4172/2155-9554.1000356.Peer-Reviewed Case Reports and Technical NotesDiscoid lupus erythematosusLinear lichen planusLupus erythematosusLichen planusBlaschko's linesModerate symptomatic benefitRare dermatologic diseaseRelevant therapeutic targetSomatic mosaicismBlaschkolinear distributionSymptomatic benefitTopical steroidsCutaneous manifestationsLP patientsLichenoid lesionsDLE patientsInflammatory disordersInflammatory diseasesEfficacious therapyDermatologic diseasesInflammatory reactionEpidermal nevusLinear lesionsNevus sebaceusTherapeutic target
2000
Utilization and effectiveness of a weight-based heparin nomogram at a large academic medical center.
Balcezak TJ, Krumholz HM, Getnick GS, Vaccarino V, Lin ZQ, Cadman EC. Utilization and effectiveness of a weight-based heparin nomogram at a large academic medical center. The American Journal Of Managed Care 2000, 6: 329-38. PMID: 10977433.Peer-Reviewed Original ResearchConceptsWeight-based nomogramWeight-based heparin nomogramTherapeutic rangeTherapeutic thresholdHeparin nomogramIntravenous heparin therapyProportion of patientsProspective cohort analysisLarge academic medical centerInternal medicine serviceComputerized order entry systemAcademic medical centerEffective patient careSupratherapeutic aPTTsHeparin therapyConsecutive patientsOrder entry systemEfficacious therapyMedical CenterCohort analysisMedicine servicePatient carePhysician behaviorNomogramPatients
1999
Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes
Krumholz H. Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes. Contemporary Cardiology 1999, 601-610. DOI: 10.1007/978-1-59259-731-4_25.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary heart diseaseHealth care resourcesCost-effectiveness analysisHealth care systemHealth care expendituresCoronary syndromeCardiac eventsPharmacologic interventionsHeart diseaseEfficacious therapyCardiovascular diseaseCare resourcesNew interventionsCare expendituresCare systemHealth benefitsInterventionCare organizationsDiseaseTreatmentStandard practicePatientsHospitalSyndrome
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply