2023
Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection
Urie R, Xiao C, Hughes E, Lombard E, Chen J, Morris A, Farris D, Goldstein D, Shea L. Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection. The Journal Of Immunology 2023, 210: 173.40-173.40. DOI: 10.4049/jimmunol.210.supp.173.40.Peer-Reviewed Original ResearchAcute cellular allograft rejectionEndomyocardial biopsyRisk of rejectionAllograft rejectionT cell-mediated rejectionRoutine endomyocardial biopsyCellular allograft rejectionHeterotopic heart transplantationMinimally-invasive samplingHealthy allograftsPersonalized immunosuppressionGraft biopsyPredictive biomarkersImmune suppressionHeart transplantationImmune cellsInvasive biopsyImmunological nicheHistological evidenceSkin transplantationBiopsyHistological evaluationGene profilesMolecular biomarkersPorous biomaterials
2019
The Man with 2 Hearts: 25 Years from Heterotopic to Orthotopic Heart Transplantation
Godfrey E, Kueht M, Rana A, Frazier O. The Man with 2 Hearts: 25 Years from Heterotopic to Orthotopic Heart Transplantation. Texas Heart Institute Journal 2019, 46: 199-202. PMID: 31708703, PMCID: PMC6827470, DOI: 10.14503/thij-17-6544.Peer-Reviewed Original ResearchConceptsHeterotopic heart transplantationHeart transplantationOrthotopic transplantationHeart failureHuman leukocyte antigen mismatchesIntra-aortic balloon pumpIdiopathic nonischemic cardiomyopathyOrthotopic heart transplantationEnd-stage heart failureManagement of end-stage heart failureMechanical circulatory supportCoronary artery stentingAntigen mismatchesNonischemic cardiomyopathyGraft survivalMedical therapyBalloon pumpHeterotopic allograftsCardiac supportArtery stentingMechanical circulatory assist devicesPoor histocompatibilityTransplantationHeart functionNative heart function
2018
Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation
Habertheuer A, Korutla L, Rostami S, Reddy S, Lal P, Naji A, Vallabhajosyula P. Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation. Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 2479-2489. PMID: 29499866, DOI: 10.1016/j.jtcvs.2017.12.125.Peer-Reviewed Original ResearchConceptsEarly acute rejectionDonor heartsAcute rejectionHeart transplantationStudy armsImmunologic rejectionMaintenance armHeterotopic heart transplantation modelAllogeneic heart transplantationTime pointsHeart transplantation modelHeterotopic heart transplantationAbsence of rejectionNovel biomarker platformDevelopment of biomarkersNoninvasive monitoringTransplant heartCardiac allograftsImmunocompetent recipientsAllograft monitoringImmunodeficient recipientsRecipient circulationTransplantation modelDay 1Total plasma
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