2025
Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
Li A, Coffey L, Mohr E, Raper J, Chahroudi A, Ausderau K, Aliota M, Friedrich T, Mitzey A, Koenig M, Golos T, Jaeger H, Roberts V, Lo J, Smith J, Hirsch A, Streblow D, Newman C, O’Connor D, Lackritz E, Van Rompay K, Waldorf K, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection. The Lancet Microbe 2025, 6: 101030. PMID: 40024258, PMCID: PMC12145256, DOI: 10.1016/j.lanmic.2024.101030.Peer-Reviewed Original ResearchNon-human primate modelZika virus infectionZika virus researchPrimate modelVirus infectionCases of congenital microcephalyFetal brain injuryLaboratory-confirmed casesGestational ageZika virus strainsBrain injuryPerinatal complicationsZika virus epidemicTesting medical countermeasuresCongenital microcephalyGlobal health concernVirus researchDevelopmental abnormalitiesZika virusVirus strainsMedical countermeasuresCongenital brain injuryInfectionZikaVirus epidemic
2020
Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva
Abbo SR, Vogels CBF, Visser TM, Geertsema C, van Oers MM, Koenraadt CJM, Pijlman GP. Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva. Viruses 2020, 12: 659. PMID: 32575394, PMCID: PMC7354520, DOI: 10.3390/v12060659.Peer-Reviewed Original ResearchConceptsZika virusGuillain-Barré syndromeZika virus infectionInfectious blood mealUrban transmission cyclesMosquito-borne pathogenMosquito salivaZIKV transmissionOral exposureVirus infectionCongenital microcephalySevere diseaseIntrathoracic injectionLarge outbreakVirus disseminationUsutu virusMidgut barrierBarrier functionMosquito midgutVirus transmissionSalivaBlood mealYellow fever mosquitoVector competenceVirusTRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes
Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses 2020, 12: 519. PMID: 32397176, PMCID: PMC7290343, DOI: 10.3390/v12050519.Peer-Reviewed Original ResearchConceptsZika virusZIKV replicationZIKV NS1 proteinGuillain-Barré syndromeNS1 proteinTRiC/CCT complexPromising therapeutic targetZIKV infectionCongenital microcephalySpecific treatmentTherapeutic targetHost factorsVirusMosquitoesSyndromeVaccineSymptomsInfectionMicrocephalyProteinReplicationImportant roleThe invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus
Abbo SR, Visser TM, Wang H, Göertz GP, Fros JJ, Abma-Henkens MHC, Geertsema C, Vogels CBF, Koopmans MPG, Reusken CBEM, Hall-Mendelin S, Hall RA, van Oers MM, Koenraadt CJM, Pijlman GP. The invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus. PLOS Neglected Tropical Diseases 2020, 14: e0008217. PMID: 32282830, PMCID: PMC7153878, DOI: 10.1371/journal.pntd.0008217.Peer-Reviewed Original ResearchConceptsZika virusUsutu virusFed mosquitoesMidgut barrierMosquito midgut barrierGuillain-Barré syndromeInfectious blood mealSevere neurological impairmentSevere congenital microcephalyField-collected AeWest Nile virusClinical manifestationsMild diseaseUSUV infectionNeurological impairmentCongenital microcephalyRNA responseVirus disseminationArboviral diseasesNile virusVirus transmissionDroplet feedingVirusFemale mosquitoesBlood meal
2017
Zika Virus -10 Public Health Achievements in 2016 and Future Priorities.
Oussayef N, Pillai S, Honein M, Ben Beard C, Bell B, Boyle C, Eisen L, Kohl K, Kuehnert M, Lathrop E, Martin S, Martin R, McAllister J, McClune E, Mead P, Meaney-Delman D, Petersen B, Petersen L, Polen K, Powers A, Redd S, Sejvar J, Sharp T, Villanueva J, Jamieson D. Zika Virus -10 Public Health Achievements in 2016 and Future Priorities. MMWR Morbidity And Mortality Weekly Report 2017, 65: 1482-1488. PMID: 28056005, DOI: 10.15585/mmwr.mm6552e1.Peer-Reviewed Original ResearchConceptsZika virusPregnant womenZika virus infectionEffective reversible contraceptionPersonal protective practicesPublic health achievementsPublic health activitiesPublic health agenciesPublic health emergencyWorld Health OrganizationSexual transmissionUnintended pregnancyReversible contraceptionVirus infectionCongenital microcephalyEmergency Operations CenterHealth achievementsHealth activitiesHealth agenciesHealth OrganizationHealth emergencyPregnancyVirusProtective practicesWomen
2016
Zika virus: History, emergence, biology, and prospects for control
Weaver SC, Costa F, Garcia-Blanco MA, Ko AI, Ribeiro GS, Saade G, Shi PY, Vasilakis N. Zika virus: History, emergence, biology, and prospects for control. Antiviral Research 2016, 130: 69-80. PMID: 26996139, PMCID: PMC4851879, DOI: 10.1016/j.antiviral.2016.03.010.Peer-Reviewed Original Research
2013
Deficiency of Asparagine Synthetase Causes Congenital Microcephaly and a Progressive Form of Encephalopathy
Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, Hitomi Y, Lu YF, Yao X, Hamdan FF, Pelak K, Reznik-Wolf H, Bar-Joseph I, Oz-Levi D, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Anikster Y, Ben-Asher E, Olender T, Colleaux L, Décarie JC, Blaser S, Banwell B, Joshi RB, He XP, Patry L, Silver RJ, Dobrzeniecka S, Islam MS, Hasnat A, Samuels ME, Aryal DK, Rodriguiz RM, Jiang YH, Wetsel WC, McNamara JO, Rouleau GA, Silver DL, Lancet D, Pras E, Mitchell GA, Michaud JL, Goldstein DB. Deficiency of Asparagine Synthetase Causes Congenital Microcephaly and a Progressive Form of Encephalopathy. Neuron 2013, 80: 429-441. PMID: 24139043, PMCID: PMC3820368, DOI: 10.1016/j.neuron.2013.08.013.Peer-Reviewed Original ResearchConceptsCongenital microcephalyProgressive cerebral atrophyStructural brain abnormalitiesCerebral atrophyNeuronal damageEnhanced excitabilityIntractable seizuresAsparagine depletionNeurological impairmentBrain abnormalitiesCortical thicknessLoss of functionASNS deficiencyProgressive formMutant micePatient phenotypesIntellectual disabilityASNS geneMicrocephalyMissense mutationsBrainDeficiencyAspartate/MutationsRecessive mutations
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