2021
Zika Virus Non-Structural Protein 1 Antigen-Capture Immunoassay
Beddingfield B, Hartnett J, Wilson R, Kulakosky P, Andersen K, Robles-Sikisaka R, Grubaugh N, Aybar A, Nunez M, Fermin C, Garry R. Zika Virus Non-Structural Protein 1 Antigen-Capture Immunoassay. Viruses 2021, 13: 1771. PMID: 34578352, PMCID: PMC8473068, DOI: 10.3390/v13091771.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralAntigens, ViralCross ReactionsDengueDengue VirusEnzyme-Linked Immunosorbent AssayEpitopesFemaleFlavivirusHumansImmunoassayImmunologic TestsModels, MolecularMutagenesis, Site-DirectedPregnancyViral Nonstructural ProteinsWest Nile virusYellow fever virusZika VirusZika Virus InfectionConceptsZIKV nonstructural protein 1Nonstructural protein 1Antigen capture ELISADengue virusZika virusMild self-limiting illnessSelf-limiting illnessNS1 proteinMajor birth defectsSevere neurological diseaseYellow fever virusAntigen capture immunoassaySt. Louis encephalitis virusPolyclonal antibodiesLouis encephalitis virusWest Nile virusSerious outcomesAffinity-purified polyclonal antibodiesRelated flavivirusesNeurological diseasesRefinement of approachesEncephalitis virusWidespread flavivirusFlavivirusesFever virus
2020
TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes
Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses 2020, 12: 519. PMID: 32397176, PMCID: PMC7290343, DOI: 10.3390/v12050519.Peer-Reviewed Original ResearchConceptsZika virusZIKV replicationZIKV NS1 proteinGuillain-Barré syndromeNS1 proteinTRiC/CCT complexPromising therapeutic targetZIKV infectionCongenital microcephalySpecific treatmentTherapeutic targetHost factorsVirusMosquitoesSyndromeVaccineSymptomsInfectionMicrocephalyProteinReplicationImportant role
2016
Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes
Liu J, Liu Y, Nie K, Du S, Qiu J, Pang X, Wang P, Cheng G. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology 2016, 1: 16087. PMID: 27562253, PMCID: PMC5003325, DOI: 10.1038/nmicrobiol.2016.87.Peer-Reviewed Original ResearchConceptsNonstructural protein 1Japanese encephalitis virus nonstructural protein 1Dengue virusDENV nonstructural protein 1Flavivirus nonstructural protein 1Lethal DENV challengeNS1 proteinReceptor-deficient miceVirus nonstructural protein 1Flavivirus NS1 proteinAcquisition of virusDENV challengeActive immunizationFlaviviral diseasesImmune barrierHost serumViral transferInfected mammalian hostsViral acquisitionMosquito midgutMiceProtein 1Virus acquisitionImmunizationMosquito vectorsThe RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion
Moriyama M, Chen I, Kawaguchi A, Koshiba T, Nagata K, Takeyama H, Hasegawa H, Ichinohe T. The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion. Journal Of Virology 2016, 90: 4105-4114. PMID: 26865721, PMCID: PMC4810543, DOI: 10.1128/jvi.00120-16.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCarrier ProteinsHEK293 CellsHeLa CellsHumansInflammasomesInterleukin-1betaMacrophagesMice, Inbred C57BLMitochondrial MembranesNLR Family, Pyrin Domain-Containing 3 ProteinRNATranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesViral Nonstructural ProteinsConceptsIL-1β secretionNonstructural protein 1Virus M2 proteinSuppression of NLRP3NS1 proteinNS1 RNAInfluenza virusM2 proteinIL-18Influenza virus NS1 proteinInterleukin-1βMultimolecular protein complexesProtein 1Inflammasome-mediated IL-1β secretionLike receptor family pyrinCaspase-1New anti-inflammatory drugsVirus NS1 proteinRecent pandemic strainJ774A.1 macrophagesPrecise mechanismNLRP3 inflammasome activationAnti-inflammatory drugsProtein complexesInnate immune sensing
1995
DNA replication in the autonomous parvoviruses
Cotmore S, Tattersall* P. DNA replication in the autonomous parvoviruses. Seminars In Virology 1995, 6: 271-281. DOI: 10.1006/smvy.1995.0033.Peer-Reviewed Original ResearchShort palindromic sequencesSpecific origin sequencesUnit-length genomesDNA synthesisViral NS1 proteinProgeny DNA synthesisLeading-strand synthesisSingle-strand nicksDNA replicationDNA genomeOrigin sequencesPalindromic sequenceAutonomous parvovirusesGenomeNew copiesNS1 proteinTelomeresReplicationOngoing replication
1993
Nuclear Targeting of the Parvoviral Replicator Molecule NS1: Evidence for Self-Association Prior to Nuclear Transport
Nüesch J, Tattersall P. Nuclear Targeting of the Parvoviral Replicator Molecule NS1: Evidence for Self-Association Prior to Nuclear Transport. Virology 1993, 196: 637-651. PMID: 8372437, DOI: 10.1006/viro.1993.1520.Peer-Reviewed Original ResearchConceptsNuclear localizationMutant NS1 proteinsNS1 polypeptideMutant NS1Nuclear localization signalNS1 proteinMajor non-structural proteinsAmino acid substitutionsParvovirus minute virusNon-structural proteinsLocalization signalPutative NTPNuclear transportLysine motifNuclear targetingMammalian cellsSubstitution mutantsExpression systemAcid substitutionsFrame deletionDouble lysineProteinMinute virusSubcellular fractionsViral DNA
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