2023
High dietary K+ intake inhibits proximal tubule transport
Wang T, Liu T, Xu S, Frindt G, Weinstein A, Palmer L. High dietary K+ intake inhibits proximal tubule transport. American Journal Of Physiology. Renal Physiology 2023, 325: f224-f234. PMID: 37318989, PMCID: PMC10396284, DOI: 10.1152/ajprenal.00013.2023.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFree-flow micropunctureUrine volumeFractional excretion of Na<sup>+</sup>Proximal tubulesFiltration rateFractional NaNephron segmentsExcretion of Na<sup>+</sup>Dietary K<sup>+</sup>NHE3 protein expressionExchanger isoform 3Increased urine volumeIncreased fractional excretionVolume reabsorptionAbsolute NaKidney functionProtein expressionIsoform 3PT transportAnesthetized animalsReabsorptionWestern blottingRatsExcretion
2013
Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals
Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA, Carson RE. Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals. Journal Of Nuclear Medicine 2013, 54: 1962-1968. PMID: 24115528, PMCID: PMC3857935, DOI: 10.2967/jnumed.113.122077.Peer-Reviewed Original ResearchConceptsHead restraintAwake nonhuman primatesAwake conditionNonhuman primatesInfrared cameraAnesthetized conditionMechanical devicesAminobutyric acid type AIsoflurane-anesthetized conditionIntravenous catheter insertionClose agreementIsoflurane-anesthetized monkeysSmall animal PET scannerTranslational research approachAnimal PET scannerFlumazenil administrationCatheter insertionNHP studiesAnesthetized monkeysConstant infusion methodPET scansPET scannerAnesthetized animalsCortisol levelsCustom chair
2010
Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals
Chin CL, Upadhyay J, Marek GJ, Baker SJ, Zhang M, Mezler M, Fox GB, Day M. Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals. Journal Of Pharmacology And Experimental Therapeutics 2010, 336: 709-715. PMID: 21172908, DOI: 10.1124/jpet.110.173880.Peer-Reviewed Original ResearchConceptsPharmacological magnetic resonance imagingMagnetic resonance imagingBrain activationPeriaqueductal grayMetabotropic Glutamate 2/3 Receptor AgonistN-methyl-D-aspartate receptor antagonistResonance imagingBOLD signalEarly clinical trialsNegative BOLD signalsNovel experimental therapeuticsPositive BOLD signalRegion-specific mannerPhMRI studiesReceptor antagonistPharmacodynamic biomarkersReceptor agonistSubanesthetic doseAgonist modulationClinical trialsAwake ratsHippocampal regionBasic research findingsDose selectionAnesthetized animals
1998
SMALL MAMMAL SURVIVAL AND TRAPABILITY IN MARK-RECAPTURE MONITORING PROGRAMS FOR HANTAVIRUS
Parmenter C, Yates T, Parmenter R, Mills J, Childs J, Campbell M, Dunnum J, Milner J. SMALL MAMMAL SURVIVAL AND TRAPABILITY IN MARK-RECAPTURE MONITORING PROGRAMS FOR HANTAVIRUS. Journal Of Wildlife Diseases 1998, 34: 1-12. PMID: 9476220, DOI: 10.7589/0090-3558-34.1.1.Peer-Reviewed Original ResearchConceptsSin Nombre virusOral cavityOrbital sinus punctureHigh mortality ratePrevalence of infectionSNV infectionSinus punctureHantavirus researchBlood samplesNombre virusOral swabsMortality of animalsMortality rateAnesthetized animalsLong-term studiesBlood/salivaMurid rodentsBuccal cellsZoonotic agentsAnesthesiaRodentsInfectionMortalitySalivaSignificant effect
1996
Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats
Krystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.Peer-Reviewed Original ResearchConceptsL-type calcium channel antagonistLocus coeruleus neuronsMorphine-dependent ratsOpiate-dependent ratsCalcium channel antagonistsSingle-unit recordingsLocus coeruleus activationNimodipine effectCoeruleus neuronsNoradrenergic mechanismsOpiate withdrawalLocus coeruleusChannel antagonistsAnesthetized animalsNimodipineAbstinence behaviorTime courseRatsWithdrawal behaviorActivationNaltrexoneCoeruleus
1991
Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration
Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.Peer-Reviewed Original ResearchConceptsAcid administrationKynurenic acidSubcutaneous administrationPeripheral excitatory amino acid receptorsExcitatory amino acid antagonist kynurenic acidExcitatory amino acid receptorsAntagonist kynurenic acidExcitatory amino acidsAmino acid receptorsLocus coeruleus neuronsMorphine-dependent ratsBlood-brain barrierSingle-unit recordingsMorphine withdrawalCoeruleus neuronsAntagonist treatmentAbstinence symptomsOpiate withdrawalUnit recordingsAnesthetized animalsAcid receptorsBehavioral signsAdministrationDifferential effectsWithdrawal
1987
Electrical coupling differs in the in vitro and in vivo organ of Corti
Santos-Sacchi J. Electrical coupling differs in the in vitro and in vivo organ of Corti. Hearing Research 1987, 25: 227-232. PMID: 3558131, DOI: 10.1016/0378-5955(87)90094-3.Peer-Reviewed Original ResearchConceptsOrgan of CortiBony cochleaVivo preparationInner earLateral wallGuinea pig organAnesthetized animalsPig organsStria vascularisEndolymphatic potentialCortiReissner's membraneMedium 199Perfusion chamberCochleaVivo experimentsApical sideOrgansKCl electrodesM KCl electrodesElectrical couplingUnique microenvironmentCellsEarThird turn
1983
Evidence for bidirectional net movement of creatinine in the rat kidney
Namnum P, Insogna K, Baggish D, Hayslett JP. Evidence for bidirectional net movement of creatinine in the rat kidney. American Journal Of Physiology 1983, 244: f719-f723. PMID: 6859263, DOI: 10.1152/ajprenal.1983.244.6.f719.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateCreatinine levelsConscious ratsPlasma creatinineFiltration ratePlasma creatinine levelsElevated plasma creatinineInulin clearance ratioIntravenous infusionEndogenous creatinineCreatinineAnesthetized animalsRenal tubulesNet secretionReliable markerRat kidneyRatsMetabolic studiesClearance ratioTest substancesCreatinine transportInfusion
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