2025
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches.
Cakir B, Tanaka Y, Choe M, Chu P, Xiang Y, Kim K, Zhong M, Gelernter J, Zhang H, Krystal J, Park I. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. International Journal Of Stem Cells 2025 PMID: 40205763, DOI: 10.15283/ijsc24123.Peer-Reviewed Original ResearchHuman embryonic stem cell linesAlcohol dependenceAD-associated variantsEmbryonic stem cell linesReporter gene analysisFyn tyrosine kinase geneTyrosine kinase geneStem cell linesCRISPR-Cas9 editingAssociated with ADVulnerability to ADAD-associatedKinase geneC alleleC/T allelesMultiple polymorphismsFunctional validationGene analysisEthanol treatmentNeuropsychiatric disordersInduced neuronsAD treatmentGene editingCell linesDisease mechanisms
1996
Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells
Katz M, Carangelo R, Miller LJ, Gorelick F. Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells. American Journal Of Physiology 1996, 270: g171-g175. PMID: 8772515, DOI: 10.1152/ajpgi.1996.270.1.g171.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsEffects of ethanolAbility of ethanolAcinar cellsHigh dosesLow dose cholecystokininCholecystokinin receptor antagonistDose of ethanolReceptor antagonistCholecystokininSmall intestineCholecystokinin receptorsEthanol treatmentActive formCarbamylcholineZymogen conversionIntracellular conversionDosesPancreatic zymogensCellsAntagonistDoseIntestine
1995
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system
Ortiz J, Fitzgerald L, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman R, Nestler E. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995, 21: 289-298. PMID: 8869159, DOI: 10.1002/syn.890210403.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic ethanol exposure resultsMesolimbic dopamine systemChronic ethanol treatmentEthanol exposure resultsAction of ethanolDopamine systemEthanol exposureNucleus accumbensGlutamate receptorsProtein immunoreactivityTyrosine hydroxylaseNeural pathwaysGlial fibrillary acidic protein immunoreactivityEthanol treatmentLong-term ethanol exposureNigrostriatal dopamine systemChronic ethanol exposureExposure resultsNMDA glutamate receptorsTyrosine hydroxylase expressionAMPA glutamate receptorsGABAA receptor complexLevels of immunoreactivityNeurofilament protein immunoreactivity
1992
Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors
Engberg G, Hajós M. Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors. Naunyn-Schmiedeberg's Archives Of Pharmacology 1992, 346: 437-441. PMID: 1436128, DOI: 10.1007/bf00171087.Peer-Reviewed Original ResearchConceptsChronic ethanol treatmentExcitatory amino acid neurotransmissionExcitatory amino acid receptorsNoradrenergic locus coeruleus neuronsEthanol treatmentAmino acid neurotransmissionAmino acid receptorsLocus coeruleus neuronsEthanol-treated ratsMK-801 doseAlcohol withdrawal reactionsEAA receptorsEAA antagonistsLC neuronsCoeruleus neuronsClinical signsWithdrawal reactionsNeurons accountsAcid receptorsAbstinence reactionsElectrophysiological evidenceAdaptive changesTreatmentNeuronsReceptorsEthanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo
Engberg G, Hajós M. Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo. Naunyn-Schmiedeberg's Archives Of Pharmacology 1992, 345: 222-226. PMID: 1314963, DOI: 10.1007/bf00165740.Peer-Reviewed Original ResearchConceptsLocus coeruleus neuronsCoeruleus neuronsLocus coeruleus noradrenergic neuronsExcitatory amino acid agonistsLocus coeruleus responseAmino acid agonistsExcitatory amino acidsAdministration of ethanolExtracellular recording techniquesEffects of ethanolMicroiontophoretic applicationNoradrenergic neuronsGlutamate excitationHippocampal slicesLocus coeruleusEthanol intoxicationElectrophysiological studiesEthanol treatmentFiring patternsNeuronsRecording techniquesUnderlaying mechanismPresent studyVivoKainate
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